Drug Information

  


    







Pharmacokinetics

Enalapril is rapidly absorbed after oral
administration with bioavailability of 60%. It is highly protein bound.
It is excreted via Kidneys.

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Indication & Dosage

Oral

ESSENTIAL AND RENAL HYPERTENSION:
Start with 5mg/day and increase
gradually as required. Usual range for maintenace is 10-20mg once daily.

CONGESTIVE FAILURE: Start with 2.5mg once daily and build up gradually
in the range of 5-20mg/day given once or in two divided doses. Digtalis
and diuretics may be continued. Renal impairment: Start with 2.5mg once
daily. Preferable to stop diuretics for 2-3days before starting
enalapril. Elderly: Started at 2.5mg daily and dosage built up as
required

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Action

After de-esterification
into the active enalaprilat, there is potent inhibition of ACE, reduced
lovels of angitensin II (AT II) and reduced aldosteronel levels.
Clinically blood pressure is reduced, salt and water retention is
corrected adn patients with congestive failure show considerable relief
of symptoms. Ventricular hypertrophy is reversed. Renal blood flow is
increased but in patients with renal impairment there may be oliguria or
acute renal failure.

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Interactions

Risk of bone marrow depression when used with
immunosupressive agents. It causes hyperkalaemia with potassium sparing
diuretics,.NSAID’s may reduce the hypotensive action .

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Adverse Effect
& Precaution




Skin rash, dry cough, headache, nausea, diarhoea, hypersensitivity

Allergies: Allergic reaction to Enalapril may occur. Pregnancy:
Enalapril may causes the foetus to be smaller than normal. Studies in
rabbits have shown that enalapril causes an increase in foetal death.

Pregnancy: Contraindicated.

Breast Feeding: Use with caution.

Man: May be used with caution.

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Brands available in Market

 







































































































ACEPRIL

Saga Labs
TAB 2.5mg 10 8.80
TAB 5mg 10 15.00
BQL

Cadila Healthcare
TAB

2.5mg
10 8.80
TAB 5mg 10 15.00
TAB 10mg 10 28.40
CONVERTEN

Khandelwal
TAB

2.5mg
10 9.60
TAB 5mg 10 16.59
TAB 10mg 10 30.09
ENA

Menarini Raunaq
TAB 2.5mg 10 10.30
TAB 5mg 10 18.07
ENACE

Nicholas-Piramal
TAB

2.5mg


10
9.31
TAB 5mg 10 17.01
TAB 10mg 10 31.19
ENALAP

Mapra
TAB

2.5mg
10 7.08
TAB 5mg 10 14.73
TAB 10mg 10 22.33
ENAM

Dr.Reddy’s
TAB

2.5mg
10 12.60
TAB 5mg 10 17.35
TAB 10mg 10 32.22
ENAMATE

Glenmark
TAB

2.5mg
10 8.75
TAB 5mg 10 15.89
TAB 10mg 10 28.19
ENAPRIL

Intas
TAB

2.5mg
10 7.58
TAB 5mg 10 12.48
TAB 10mg 10 23.14
TAB 20mg 10 47.72
ENCARDIL

Medley
TAB

2.5mg
10 9.50
TAB 5mg 10 16.50
TAB 10mg 10 29.50
ENPRIL

Wockhardt
TAB

2.5mg
10 7.03
TAB 5mg 10 11.99
TAB 10mg 10 21.83
ENVAS

Cadila Pharma
TAB

2.5mg
10 10.25
TAB 5mg 10 17.25
TAB 10mg 10 32.00
TAB 20mg

60.60
EMP

10 Grandix
TAB 5mg 10 18.80
HYTROL

10 Sun Pharma
TAB

2.5mg
10 9.40
TAB 5mg 10 17.10
TAB 10mg 10 30.00
INVORIL

Stancare
TAB

2.5mg
10 10.40
TAB 5mg 10 18.75
TAB 10mg 10 33.35
MINIPRIL

Alembic
TAB

2.5mg
10 9.30
TAB 5mg 10 16.10
TAB 10mg 10 28.50
MYOACE

Merck
TAB

2.5mg
10 9.25
TAB 5mg 10 16.75
TAB 10mg 10 27.75
NEWACE

Max
TAB

2.5mg
10 10.00
TAB 5mg 10 18.00
TAB 10mg 10 32.00
NORMACE

Unisearch
TAB

2.5mg
10 8.55
TAB 5mg 10 15.00
TAB 10mg 10 27.45
NURIL

USV
TAB

2.5mg
10 12.00
TAB 5mg 10 19.00
TAB 10mg 10 31.00
OREN

Natco
TAB

2.5mg
10 8.72
TAB 5mg 10 16.20
TAB 10mg 10 30.00
TAB 20mg 10 55.32
TENFRI

Pace(SOL)
TAB

2.5mg
10 9.70
TAB 5mg 10 15.16
TAB 10mg 10 28.65
VASONORM

Kopran
TAB 2.5mg 10 8.30
TAB 5mg 10 15.10
VASOPRIL

Protec
TAB 2.5mg 10 8.95
TAB 5mg 10 15.91
VIVIRIL

Sarabhai
TAB

2.5mg
10 9.66
TAB 5mg 10 14.14
TAB 10mg 10 26.97




 

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Drug Information
  

    

Pharmacokinetics

Enalapril is rapidly absorbed after oral administration with bioavailability of 60%. It is highly protein bound. It is excreted via Kidneys.

Top
 
   

Indication & Dosage

Oral
ESSENTIAL AND RENAL HYPERTENSION:
Start with 5mg/day and increase gradually as required. Usual range for maintenace is 10-20mg once daily.
CONGESTIVE FAILURE: Start with 2.5mg once daily and build up gradually in the range of 5-20mg/day given once or in two divided doses. Digtalis and diuretics may be continued. Renal impairment: Start with 2.5mg once daily. Preferable to stop diuretics for 2-3days before starting enalapril. Elderly: Started at 2.5mg daily and dosage built up as required

Top
 
   

Action

After de-esterification into the active enalaprilat, there is potent inhibition of ACE, reduced lovels of angitensin II (AT II) and reduced aldosteronel levels. Clinically blood pressure is reduced, salt and water retention is corrected adn patients with congestive failure show considerable relief of symptoms. Ventricular hypertrophy is reversed. Renal blood flow is increased but in patients with renal impairment there may be oliguria or acute renal failure.

Top
 
   

Interactions

Risk of bone marrow depression when used with immunosupressive agents. It causes hyperkalaemia with potassium sparing diuretics,.NSAID’s may reduce the hypotensive action .

Top
 
   

Adverse Effect & Precaution

Skin rash, dry cough, headache, nausea, diarhoea, hypersensitivity

Allergies: Allergic reaction to Enalapril may occur. Pregnancy: Enalapril may causes the foetus to be smaller than normal. Studies in rabbits have shown that enalapril causes an increase in foetal death.
Pregnancy: Contraindicated.
Breast Feeding: Use with caution.
Man: May be used with caution.

Top
 
   

ACEPRIL

Saga Labs

TAB

2.5mg

10

8.80

TAB

5mg

10

15.00

BQL

Cadila Healthcare

TAB

2.5mg

10

8.80

TAB

5mg

10

15.00

TAB

10mg

10

28.40

CONVERTEN

Khandelwal

TAB

2.5mg

10

9.60

TAB

5mg

10

16.59

TAB

10mg

10

30.09

ENA

Menarini Raunaq

TAB

2.5mg

10

10.30

TAB

5mg

10

18.07

ENACE

Nicholas-Piramal

TAB

2.5mg

10

9.31

TAB

5mg

10

17.01

TAB

10mg

10

31.19

ENALAP

Mapra

TAB

2.5mg

10

7.08

TAB

5mg

10

14.73

TAB

10mg

10

22.33

ENAM

Dr.Reddy’s

TAB

2.5mg

10

12.60

TAB

5mg

10

17.35

TAB

10mg

10

32.22

ENAMATE

Glenmark

TAB

2.5mg

10

8.75

TAB

5mg

10

15.89

TAB

10mg

10

28.19

ENAPRIL

Intas

TAB

2.5mg

10

7.58

TAB

5mg

10

12.48

TAB

10mg

10

23.14

TAB

20mg

10

47.72

ENCARDIL

Medley

TAB

2.5mg

10

9.50

TAB

5mg

10

16.50

TAB

10mg

10

29.50

ENPRIL

Wockhardt

TAB

2.5mg

10

7.03

TAB

5mg

10

11.99

TAB

10mg

10

21.83

ENVAS

Cadila Pharma

TAB

2.5mg

10

10.25

TAB

5mg

10

17.25

TAB

10mg

10

32.00

TAB

20mg

60.60

EMP

10

Grandix

TAB

5mg

10

18.80

HYTROL

10

Sun Pharma

TAB

2.5mg

10

9.40

TAB

5mg

10

17.10

TAB

10mg

10

30.00

INVORIL

Stancare

TAB

2.5mg

10

10.40

TAB

5mg

10

18.75

TAB

10mg

10

33.35

MINIPRIL

Alembic

TAB

2.5mg

10

9.30

TAB

5mg

10

16.10

TAB

10mg

10

28.50

MYOACE

Merck

TAB

2.5mg

10

9.25

TAB

5mg

10

16.75

TAB

10mg

10

27.75

NEWACE

Max

TAB

2.5mg

10

10.00

TAB

5mg

10

18.00

TAB

10mg

10

32.00

NORMACE

Unisearch

TAB

2.5mg

10

8.55

TAB

5mg

10

15.00

TAB

10mg

10

27.45

NURIL

USV

TAB

2.5mg

10

12.00

TAB

5mg

10

19.00

TAB

10mg

10

31.00

OREN

Natco

TAB

2.5mg

10

8.72

TAB

5mg

10

16.20

TAB

10mg

10

30.00

TAB

20mg

10

55.32

TENFRI

Pace(SOL)

TAB

2.5mg

10

9.70

TAB

5mg

10

15.16

TAB

10mg

10

28.65

VASONORM

Kopran

TAB

2.5mg

10

8.30

TAB

5mg

10

15.10

VASOPRIL

Protec

TAB

2.5mg

10

8.95

TAB

5mg

10

15.91

VIVIRIL

Sarabhai

TAB

2.5mg

10

9.66

TAB

5mg

10

14.14

TAB

10mg

10

26.97

 

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By |2022-07-20T16:41:42+00:00July 20, 2022|Uncategorized|Comments Off on Enalapril

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