Drug Information

 


     








Pharmacokinetics

After oral
administration about 50% drug is absorbed.

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Indication
& Dosage

IV
SMALL CELL LUNG CANCER, MALIGNANT LYMPHOMAS , ACUTE LEUKAEMIAS ,
TESTICULAR TUMOURS BLADDER CANCER AND TROPHOBLASTIC DISEASES :


Etoposide is given in combination with other antineoplastic drugs .
Dosage : 50-100 mg/m2/day from 1  to day 5 , or 100 mg/m2 on days
1,3 and 5 . In small cell lung cancer the doses may range between
35mg/m2/day for 4 days and 50 mg/m2 daily for 5 days. Courses may be
repeated at 3-4 week intervals after recovery from any toxicity .
Acrylic material has been shown to crack and leak when used with
undiluted etoposide injection . Etoposide injection must be diluted with
5% dextrose or normal saline to give a final concentration of 0.2 to
0.4mg/ml and injected over 30-60 minutes.

ORAL

SAMLL CELL LUNG CANCER , MALIGNANT LYMPHOMAS ,
ACUTE LEUKAEMIAS , TESTICULAR TUMOURS , BLADDER CANCER AND TROPHOBLASTIC
DISEASES :
Adults :175-200 mg daily for 5 consecutive days.
Repeat after 3 weeks . 

NOTE : Children : Etoposide is not recommended.

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ACTION

 


The predominant effect of etoposide is inhibition of DNA synthesis
resulting in arrest of cell cycle. At low doses etoposide inhibits cells
from entering cell cycle. At high doses cells entering mitosis are lysed.

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Interactions



Warfarin: Prolongation of prothrombin time may occur.

Other cytotoxic drugs Synergism.

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Adverse
Effect & Precaution




Nausea, vomiting, diarrhoea, allergic reactions, fever, hypotension,
bone marrow depression, peripheral neuropathy. Jaundice, bronchospasm.

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ASIDE

Shree
Ganesh

INJ

100mg/5ml

amp

350.00

BEPOSID

Biological
E

INJ

100mg

5ml

190.00

BIOPOSIDE

Biochem

INJ

100mg/5ml

VIAL

199.00

EPOSED

Octan

INJ

100mg

VIAL

201.30

ETOPUL

VHB

INJ

100mg/5ml

VIAL

372.00

ETOSID
CAPSULES

Cipla

CAPS

50mg

4

372.00

ETOSID
INJ

Cipla

(Etoposide
100mg, benzylalcohol 150mg, ethyl alcholol 30.5% v/v, per 5ml)

INJ

5ml

190.00

FYTOSID

Dabur

VIAL

100mg

5ML

193.00

LASTET

Khadelwal

CAPS

25mg

1

96.39

CAPS

50mg

1

189.54

CAPS

100mg

1

375.85

INJ

100mg/5ml

1amp

274.86

TEVASIDE

SSPL

INJ

100mg/5ml

1Vial

263.93

TOPOK

Max

VIAL

100mg

5ml

210.00


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Drug Information
 

     

Pharmacokinetics

After oral administration about 50% drug is absorbed.

Top
  

Indication & Dosage

IV SMALL CELL LUNG CANCER, MALIGNANT LYMPHOMAS , ACUTE LEUKAEMIAS , TESTICULAR TUMOURS BLADDER CANCER AND TROPHOBLASTIC DISEASES :
Etoposide is given in combination with other antineoplastic drugs . Dosage : 50-100 mg/m2/day from 1  to day 5 , or 100 mg/m2 on days 1,3 and 5 . In small cell lung cancer the doses may range between 35mg/m2/day for 4 days and 50 mg/m2 daily for 5 days. Courses may be repeated at 3-4 week intervals after recovery from any toxicity . Acrylic material has been shown to crack and leak when used with undiluted etoposide injection . Etoposide injection must be diluted with 5% dextrose or normal saline to give a final concentration of 0.2 to 0.4mg/ml and injected over 30-60 minutes.

ORAL
SAMLL CELL LUNG CANCER , MALIGNANT LYMPHOMAS , ACUTE LEUKAEMIAS , TESTICULAR TUMOURS , BLADDER CANCER AND TROPHOBLASTIC DISEASES : Adults :175-200 mg daily for 5 consecutive days. Repeat after 3 weeks . 
NOTE : Children : Etoposide is not recommended.

Top
  

ACTION
 

The predominant effect of etoposide is inhibition of DNA synthesis resulting in arrest of cell cycle. At low doses etoposide inhibits cells from entering cell cycle. At high doses cells entering mitosis are lysed.

Top
  

Interactions

Warfarin: Prolongation of prothrombin time may occur.
Other cytotoxic drugs Synergism.

Top
  

Adverse Effect & Precaution

Nausea, vomiting, diarrhoea, allergic reactions, fever, hypotension, bone marrow depression, peripheral neuropathy. Jaundice, bronchospasm.

Top
  

ASIDE

Shree Ganesh

INJ

100mg/5ml

amp

350.00

BEPOSID

Biological E

INJ

100mg

5ml

190.00

BIOPOSIDE

Biochem

INJ

100mg/5ml

VIAL

199.00

EPOSED

Octan

INJ

100mg

VIAL

201.30

ETOPUL

VHB

INJ

100mg/5ml

VIAL

372.00

ETOSID CAPSULES

Cipla

CAPS

50mg

4

372.00

ETOSID INJ

Cipla

(Etoposide 100mg, benzylalcohol 150mg, ethyl alcholol 30.5% v/v, per 5ml)

INJ

5ml

190.00

FYTOSID

Dabur

VIAL

100mg

5ML

193.00

LASTET

Khadelwal

CAPS

25mg

1

96.39

CAPS

50mg

1

189.54

CAPS

100mg

1

375.85

INJ

100mg/5ml

1amp

274.86

TEVASIDE

SSPL

INJ

100mg/5ml

1Vial

263.93

TOPOK

Max

VIAL

100mg

5ml

210.00

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By |2022-07-20T16:42:58+00:00July 20, 2022|Uncategorized|Comments Off on Etoposide

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