Drug Information

    



    












Pharmacokinetics

 



It is well absorbed orally, but its
bioavailablity is reduced when given with antacids. Theraupetic effect
lasts for about 5-8 hours. It is excreted mainly in the urine, within 24
hours mainly as unchanged drug. It can cross the placental barrier and
is secreted in milk.

Top

  

Indication
& Dosage


 

Oral

DUODENAL AND BENIGN GASTRIC ULCERS: 40mg once at bedtime or 20mg twice
daily. 4-8 weeks. MAINTENANCE TO PREVENT RECURRENCE:
20mg o.d at
bedtime. 

REFLEX OESOPHAGITIS: 20mg b.i.d for upto 6 weeks. If erosions are
present dose may be increased upto 40mg b.i.d for upto 12 weeks

ZOLLINGER-ELLISON SYNDROME: Start with 20mg 6hrly, adjusted upwards as
required. Children: Safety not established. Elderly: No doses changes
needed.

IV

PATHOGLOGICAL HYPERSECRETORY CONDITIONS AND INTRACTABLE ULCERS IN
HOSPITALISED PATIENTS:
Initially 20mg slow inj over 2 mins, then 20mg
given by repeated inj or infusion over 30 mins every 12 hrs.

Renal impairment: In patients with creatinine clearance less than
10ml/min the dose is reduced to 20mg once at bedtime

Top

  

Action



Competetive blockade at
histamine H2-receptors. Reduces basal, nocturnal and stimulated gastric
acid secretion. Pepsin secretion is reduced as is also peptic activity.
Effectively heals duodenal and gastric ulcers and prevents recurrence.
Reduces oesophageal reflux and is effective in Zollinger-Ellison
syndrome. No antiandrogenic effect. 

Top

  

Interaction

  

Famotidine may decrease
the effects of itraconazole or ketoconazole, hence famotidine should be
taken at least 2 hours after these drugs.

Top

  

Adverse
Effect & Precaution


 


Dizziness, headache, nausea,
vomiting, anorexia, constipation and diarrhoea. 

 


Special precautions to be taken in
pregnancy, lactation and in children .


Pregnancy: Use with
Caution.

Breast Feeding: Use with Caution.

Man: May be used.

Top

  

Brands
available in market


























































































 


ACILO

 

 

Wander

TAB

20mg

14

4.48

TAB

40mg

14

7.94

ACIPEP

 

 

Kramer

TAB

20mg

10

18.66

TAB

40mg

10

7.94

ACREDIN

 

 

Sarabhai

TAB

20mg

14

5.19

TAB

40mg

14

9.17

AUTIDINE

 

 

Aurobindo
Pharma

TAB

20mg

10

37.50

TAB

40mg

10

65.40

AXID

 

 

Saga Labs

TAB

20mg

10

3.79

TAB

40mg

10

6.77

BLOCACID

 

 

IPCA

TAB

20mg

14

5.17

TAB

40mg

14

9.13

FACID

 

 

Intas

TAB

20mg

14

5.17

TAB

40mg

14

9.14

INJ

20mg/ml

2ml

2.39

FACID AC

 

 

Intas

TAB

10mg

14

2.48

FADINE

 

 

Aristo

TAB

20mg

14

5.20

TAB

40mg

14

9.19

FAMOCID

 

 

Sun Pharma

TAB

20mg

14

8.26

TAB

40mg

14

15.26

FAMONITE

 

 

Alidac

TAB

20mg

14

5.21

TAB

40mg

14

9.21

FAMOPRIL

 

 

Recon

TAB

20mg

14

18.20

TAB

40mg

14

32.20

FAMORILA

 

 

Glenmark

TAB

20mg

14

5.15

TAB

40mg

14

9.09

FAMOTIN

 

 

USV

TAB

20mg

10

12.90

TAB

40mg

10

24.90

FAMOVANE

 

 

J.KInd.

TAB

20mg

14

15.05

TAB

40mg

14

27.30

FAMOWAL

 

 

Wallace

TAB

20mg

14

5.18

TAB

40mg

14

9.15

FAMPEP

 

 

Seagull

TAB

10mg

10

6.00

TAB

20mg

10

11.80

TAB

40mg

10

20.80

FAMTAC

 

 

Nicholas-Piramal

TAB

20mg

10

14.00

TAB

40mg

10

40.00

FEBCID

 

 

Brown &
Burk

TAB

20mg

14

5.14

TAB

40mg

14

9.08

FUDONE

 

 

Wockhardt

TAB

20mg

14

5.18

TAB

40mg

14

9.15

NOCTIN

 

 

PCI

TAB

20mg

14

29.07

TAB

40mg

14

55.31

NORFAM

 

 

Medicamen

TAB

20mg

14

5.51

TAB

40mg

14

9.86

RECID

 

 

Max

TAB

20mg

10

20.28

TAB

40mg

10

39.43

TOBUR

 

 

Themis
Pharma

TAB

20mg

14

33.00

TAB

40mg

14

63.25

TOPCID

 

 

Torrent

TAB

20mg

10

5.21

TAB

40mg

10

9.20

ULCIMAX

 

 

Protec

TAB

20mg

14

14.70

TAB

40mg

14

28.20

ZACTANE

 

 

Wyeth
Lederle

TAB

20mg

 

5.99

TAB

40mg

 

9.15

 

 

 

 



Top

 



 






 

     

    
Drug Information
    

    

Pharmacokinetics
 

It is well absorbed orally, but its bioavailablity is reduced when given with antacids. Theraupetic effect lasts for about 5-8 hours. It is excreted mainly in the urine, within 24 hours mainly as unchanged drug. It can cross the placental barrier and is secreted in milk.

Top
  

Indication & Dosage
 
Oral
DUODENAL AND BENIGN GASTRIC ULCERS: 40mg once at bedtime or 20mg twice daily. 4-8 weeks. MAINTENANCE TO PREVENT RECURRENCE:
20mg o.d at bedtime. 
REFLEX OESOPHAGITIS: 20mg b.i.d for upto 6 weeks. If erosions are present dose may be increased upto 40mg b.i.d for upto 12 weeks
ZOLLINGER-ELLISON SYNDROME: Start with 20mg 6hrly, adjusted upwards as required. Children: Safety not established. Elderly: No doses changes needed.

IV
PATHOGLOGICAL HYPERSECRETORY CONDITIONS AND INTRACTABLE ULCERS IN HOSPITALISED PATIENTS:
Initially 20mg slow inj over 2 mins, then 20mg given by repeated inj or infusion over 30 mins every 12 hrs.
Renal impairment: In patients with creatinine clearance less than 10ml/min the dose is reduced to 20mg once at bedtime

Top
  

Action

Competetive blockade at histamine H2-receptors. Reduces basal, nocturnal and stimulated gastric acid secretion. Pepsin secretion is reduced as is also peptic activity. Effectively heals duodenal and gastric ulcers and prevents recurrence. Reduces oesophageal reflux and is effective in Zollinger-Ellison syndrome. No antiandrogenic effect. 

Top
  

Interaction
  
Famotidine may decrease the effects of itraconazole or ketoconazole, hence famotidine should be taken at least 2 hours after these drugs.

Top
  

Adverse Effect & Precaution
 

Dizziness, headache, nausea, vomiting, anorexia, constipation and diarrhoea. 
 

Special precautions to be taken in pregnancy, lactation and in children .
Pregnancy: Use with Caution.
Breast Feeding: Use with Caution.
Man: May be used.

Top
  

 

ACILO

 

 

Wander

TAB

20mg

14

4.48

TAB

40mg

14

7.94

ACIPEP

 

 

Kramer

TAB

20mg

10

18.66

TAB

40mg

10

7.94

ACREDIN

 

 

Sarabhai

TAB

20mg

14

5.19

TAB

40mg

14

9.17

AUTIDINE

 

 

Aurobindo Pharma

TAB

20mg

10

37.50

TAB

40mg

10

65.40

AXID

 

 

Saga Labs

TAB

20mg

10

3.79

TAB

40mg

10

6.77

BLOCACID

 

 

IPCA

TAB

20mg

14

5.17

TAB

40mg

14

9.13

FACID

 

 

Intas

TAB

20mg

14

5.17

TAB

40mg

14

9.14

INJ

20mg/ml

2ml

2.39

FACID AC

 

 

Intas

TAB

10mg

14

2.48

FADINE

 

 

Aristo

TAB

20mg

14

5.20

TAB

40mg

14

9.19

FAMOCID

 

 

Sun Pharma

TAB

20mg

14

8.26

TAB

40mg

14

15.26

FAMONITE

 

 

Alidac

TAB

20mg

14

5.21

TAB

40mg

14

9.21

FAMOPRIL

 

 

Recon

TAB

20mg

14

18.20

TAB

40mg

14

32.20

FAMORILA

 

 

Glenmark

TAB

20mg

14

5.15

TAB

40mg

14

9.09

FAMOTIN

 

 

USV

TAB

20mg

10

12.90

TAB

40mg

10

24.90

FAMOVANE

 

 

J.KInd.

TAB

20mg

14

15.05

TAB

40mg

14

27.30

FAMOWAL

 

 

Wallace

TAB

20mg

14

5.18

TAB

40mg

14

9.15

FAMPEP

 

 

Seagull

TAB

10mg

10

6.00

TAB

20mg

10

11.80

TAB

40mg

10

20.80

FAMTAC

 

 

Nicholas-Piramal

TAB

20mg

10

14.00

TAB

40mg

10

40.00

FEBCID

 

 

Brown & Burk

TAB

20mg

14

5.14

TAB

40mg

14

9.08

FUDONE

 

 

Wockhardt

TAB

20mg

14

5.18

TAB

40mg

14

9.15

NOCTIN

 

 

PCI

TAB

20mg

14

29.07

TAB

40mg

14

55.31

NORFAM

 

 

Medicamen

TAB

20mg

14

5.51

TAB

40mg

14

9.86

RECID

 

 

Max

TAB

20mg

10

20.28

TAB

40mg

10

39.43

TOBUR

 

 

Themis Pharma

TAB

20mg

14

33.00

TAB

40mg

14

63.25

TOPCID

 

 

Torrent

TAB

20mg

10

5.21

TAB

40mg

10

9.20

ULCIMAX

 

 

Protec

TAB

20mg

14

14.70

TAB

40mg

14

28.20

ZACTANE

 

 

Wyeth Lederle

TAB

20mg

 

5.99

TAB

40mg

 

9.15

 

 

 

 

Top
 

 

 

By |2022-07-20T16:41:46+00:00July 20, 2022|Uncategorized|Comments Off on Famotidine

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