Drug Information

  


    











Pharmacokinetics

Fexofenadine
is rapidly absorbed after oral administration with peak plasma
concentrations being reached in 2 to 3 hours. It is about 60 to 70%
bound to plasma proteins. About 5% of the total dose is metabolised,
mostly by the intestinal mucosa, with only 0.5 to 1.5% of the dose
undergoing hepatic biotransformation. Elimination half-lives of about 14
hours have been reported although these may be prolonged in patients
with renal impairment. Excretion is mainly in the faeces with only 10%
being present in the urine. Fexofenadine does not appear to cross the
blood-brain barrier.

Fexofenadine
is a metabolite of terfenadine and as such has been detected in breast
milk after the administration of terfenadine.

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Indication
& Dosage


 


Oral

SEASONAL ALLERGIC RHINITIS ASSOCIATED WITH SYMPTOMS(SNEEZING,
RHINORHOEA, ITCHY NOSE/PALLATE/THROAT, ITCHY/ WATERY/RED EYES:
Adult and
children (above 12 years): 60mg bid. In patients with decreased renal
function: 60mg once daily.

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Action



Fexofenadine is
non-sedative, selective peripheral histamine H1-receptor antagoinist. It
is an active metabolite of terfenadine with no effect on the cardia QT
interval unlike terfenadine.

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Interaction



An increase in the level of fexofenadine in plasma of 2-times was
observed after coadministration of erythromycin or ketoconazole.

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Adverse
Effect & Precaution




Drowsiness, fatigue, nausea, dyspepsia, headache and leucopenia.



Pregnancy: Use only when potential benefit outweighs the potential risk
to foetus.

Breast Feeding:Not recommended.

Man: May be used
.

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Brands
available in market














 


ALLEGRA


HMR


TAB


120mg


47.31


TAB


180mg


47.31


ALTIVA


Ranbaxy


TAB


120mg


55.40


TAB


180mg


70.00








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Drug Information
  

    

Pharmacokinetics

Fexofenadine is rapidly absorbed after oral administration with peak plasma concentrations being reached in 2 to 3 hours. It is about 60 to 70% bound to plasma proteins. About 5% of the total dose is metabolised, mostly by the intestinal mucosa, with only 0.5 to 1.5% of the dose undergoing hepatic biotransformation. Elimination half-lives of about 14 hours have been reported although these may be prolonged in patients with renal impairment. Excretion is mainly in the faeces with only 10% being present in the urine. Fexofenadine does not appear to cross the blood-brain barrier.

Fexofenadine is a metabolite of terfenadine and as such has been detected in breast milk after the administration of terfenadine.

Top
   

Indication & Dosage
 
Oral
SEASONAL ALLERGIC RHINITIS ASSOCIATED WITH SYMPTOMS(SNEEZING, RHINORHOEA, ITCHY NOSE/PALLATE/THROAT, ITCHY/ WATERY/RED EYES:
Adult and children (above 12 years): 60mg bid. In patients with decreased renal function: 60mg once daily.

Top
   

Action

Fexofenadine is non-sedative, selective peripheral histamine H1-receptor antagoinist. It is an active metabolite of terfenadine with no effect on the cardia QT interval unlike terfenadine.

Top
   

Interaction

An increase in the level of fexofenadine in plasma of 2-times was observed after coadministration of erythromycin or ketoconazole.

Top
   

Adverse Effect & Precaution

Drowsiness, fatigue, nausea, dyspepsia, headache and leucopenia.

Pregnancy: Use only when potential benefit outweighs the potential risk to foetus.
Breast Feeding:Not recommended.
Man: May be used
.

Top
   

 

ALLEGRA

HMR

TAB

120mg

47.31

TAB

180mg

47.31

ALTIVA

Ranbaxy

TAB

120mg

55.40

TAB

180mg

70.00



Top
  

 

 

By |2022-07-20T16:42:57+00:00July 20, 2022|Uncategorized|Comments Off on Fexofenadine

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