Drug
Information


 


     












Pharmacokinetics

 


Finasteride is absorbed following
oral administration, and peak plasma concentrations are achieved in 1 to
2 hours. The mean bioavailability has variously been reported as 63% and
80%. It is about 90% bound to plasma protein. Finasteride is metabolised
in the liver and excreted in urine and faeces as metabolites. Mean
half-life is 6 hours in patients under 60 years of age but may be
prolonged to about 8 hours in those 70 years of age or older.

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Indication
& Dosage


 

Oral

SYMPTOMATIC BENIGN PROSTATIC
HYPERPLASIA:
5mg once daily. 6-12 months therapy may be necessary in
some patients before a beneficial effect is seen. No dose adjustment
required in patients with renal impairment.

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Action



Competetive inhibitor of
the enzyme 5-alpha reducates which converts testosterone to
dihydrotestosterone (DHT). It has no affinity for androgen 
receptors. Cnoversion of testosterone to DHT by 5 alpha reductase is
essential for prostatic hyperplasia. Finasteride has no significant
effect on circulating levels of several hormones. the hypothalamus-hypophysis-gonad
axis is not affected

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Interaction



Theophylline increased
theophylline clearance and decreased its half life.

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Adverse
Effect & Precaution


 

Increased libido, breast tenderness,
impotence and hypersenitivity reactions.



Precaution: Hepatic dysfunction, patients with large residual urine
volume, increase in PSA level.

Man: May be used

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Brands
available in market


 












 


FINAST


Dr. Reddy’s


TAB


5mg


10


86.05


FINCAR


Cipla


TAB


5mg


10


85.00


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Drug Information
 

     

Pharmacokinetics
 

Finasteride is absorbed following oral administration, and peak plasma concentrations are achieved in 1 to 2 hours. The mean bioavailability has variously been reported as 63% and 80%. It is about 90% bound to plasma protein. Finasteride is metabolised in the liver and excreted in urine and faeces as metabolites. Mean half-life is 6 hours in patients under 60 years of age but may be prolonged to about 8 hours in those 70 years of age or older.

Top
   

Indication & Dosage
 
Oral
SYMPTOMATIC BENIGN PROSTATIC HYPERPLASIA: 5mg once daily. 6-12 months therapy may be necessary in some patients before a beneficial effect is seen. No dose adjustment required in patients with renal impairment.

Top
   

Action

Competetive inhibitor of the enzyme 5-alpha reducates which converts testosterone to dihydrotestosterone (DHT). It has no affinity for androgen  receptors. Cnoversion of testosterone to DHT by 5 alpha reductase is essential for prostatic hyperplasia. Finasteride has no significant effect on circulating levels of several hormones. the hypothalamus-hypophysis-gonad axis is not affected

Top
   

Interaction

Theophylline increased theophylline clearance and decreased its half life.

Top
   

Adverse Effect & Precaution
 
Increased libido, breast tenderness, impotence and hypersenitivity reactions.

Precaution: Hepatic dysfunction, patients with large residual urine volume, increase in PSA level.
Man: May be used

Top
   

 

FINAST

Dr. Reddy’s

TAB

5mg

10

86.05

FINCAR

Cipla

TAB

5mg

10

85.00

Top
  

 

 

By |2022-07-20T16:42:56+00:00July 20, 2022|Uncategorized|Comments Off on Finastride

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