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Pharmacokinetics
| Indication
& Dosage | Action
| Interaction
Adverse
Effect & Precautions |
Brands available in Market
Pharmacokinetics
Flavoxate is readily absorbed from the gastrointestinal tract and
rapidly metabolised, about 50 to 60% of a dose being excreted in the
urine within 24 hours as methyl flavone carboxylic acid.
Indication
& Dosage
Dysuria, urgency, nocturia, frequency, incotinence & suprapubic pain
innence & suprapbic pain in cystitis, prostatitis, urethritis.
cystitis, prostatitis, urethritis. NOT indicated for definitive
treatment but is compatible with drugs used to treat UTI.
Dosage: Adult: 100-200mg 3-4 times daily. Reduce dose when symptoms
improve.
Children: Not recommended in children < 12 year.
Interaction
The effects of atropine and other antimuscarinics may be enhanced by the
concomitant administration of other drugs with antimuscarinic
properties, such as amantadine, some antihistamines, phenothiazine
antipsychotics, and tricyclic antidepressants. Inhibition of drug-metabolising
enzymes by MAOIs may possibly enhance the effects of antimuscarinics.
The reduction in gastric motility caused by antimuscarinics may affect
the absorption of other drugs. Antimuscarinics and parasympathomimetics
may counteract each others effects.
Adverse
Effect & Precaution
Nausea, vomiting, dry mouth, nervousness, vertigo, headache, drowsiness,
hyperpyrexia, blurred vision, urticaria, dysuria, tachycardia.
Preacution: Glaucoma, prostate hypertrophy, hiatus hernia wit hreflex
oesophagitis.
Pregnancy: Use only when clearly needed.
Breast Feeding: Use with caution.
Man: May cause mental confusion.
