Drug Information

  


      











 

Pharmacokinetics




It is absorbed well after oral administration. Fungicidal
concentration is achieved in nail, saliva and vagina. It also penetrates
brain.

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Indication
& Dosage


 

Oral

OROPHARYNGEAL
CANDIDIASIS
: Start 200mg followed by 100mg/day for 14 days or more.


ORSOPHAGEAL CANDIDIASIS:
Start 200mg followed by 100mg/day for 30 days


SYSTEMIC CANDIDIASIS:
Initially 400mg followed by 200mg daily for 28 day
or more.


VAGINAL CANDIDIASIS:
A single oral dose of 150mg


CRYPTOCOCCAL MENINGITIS AND OTHER CRYPTOCOCCAL INFECTIONS:
Initially
400mg followed by 200-400mg daily. Duration depends on response.
100-200mg/day to prevent relapses.


IMMUNOCOMPROMISED PATIENTS FOR PROPHYLAXIS:
50-100mg daily


IV


OROPHARYNGEAL CANDIDIASIS, OESOPHAGEAL CANDIDIASIS, SYSTEMIC
CANDISDIASIS ,VAGINAL CANDIDIASIS, CRYPTOCOCCAL MENINGITIS AND OTHER.

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Action



Found effective in
several systemic fungal infections especially in candidiasis and
cryptococcosis associated with immunosuppression as in AIDS or cancer
therapy. Susceptible pathogens include Aspergillus spp, Blastomyced
detmatitidis, Candida spp, Coccidioidies immitis, Cryptococcus
neoformans and Histoplasma capsulatum.

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Interaction



Cimetidine /
Plasma levels of fluconazole

Cisapride / Risk of
serious cardiac arrhythmias


Cyclosporine / Fluconazole may
cyclosporine levels in renal transplant clients with or without impaired
renal function


Hydrochlorothiazide /
Plasma levels of fluconazole due to
renal clearance


Glipizide / Plasma levels
of glipizide due to
breakdown by the liver


Glyburide / Plasma levels
of glyburide due to
breakdown by the liver


Phenytoin / Fluconazole
plasma levels of phenytoin


Rifampin / Plasma levels
of fluconazole due to
breakdown by the liver


Theophylline / Plasma
levels of theophylline


Tolbutamide / Plasma
levels of tolbutamide due to
breakdown by the liver


Warfarin / PT


Zidovudine / Plasma
levels of AZT


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Adverse
Effect & Precaution




Nausea, vomiting, abdominal
pain, diarrhoea, skin rash and headache.



Precaution: Liver dysfunction, children
less than 13 years

Pregnancy: Use only if potential benefit justifies the possible risk ot
the foetus.

Breast Feeding: Not recommended.

Man: Use with caution

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Brands
available in market

 












 


CANCAP


Ind-Swift


CAPS


150mg


10×2


478.00


CONCIZE


Indoco


TABS


50mg


50mg


40.00


Top

  





 






 

              

   
Drug Information
  

      

 
Pharmacokinetics


It is absorbed well after oral administration. Fungicidal concentration is achieved in nail, saliva and vagina. It also penetrates brain.

Top
  

Indication & Dosage
 
Oral
OROPHARYNGEAL CANDIDIASIS: Start 200mg followed by 100mg/day for 14 days or more.
ORSOPHAGEAL CANDIDIASIS: Start 200mg followed by 100mg/day for 30 days
SYSTEMIC CANDIDIASIS: Initially 400mg followed by 200mg daily for 28 day or more.
VAGINAL CANDIDIASIS: A single oral dose of 150mg
CRYPTOCOCCAL MENINGITIS AND OTHER CRYPTOCOCCAL INFECTIONS: Initially 400mg followed by 200-400mg daily. Duration depends on response. 100-200mg/day to prevent relapses.
IMMUNOCOMPROMISED PATIENTS FOR PROPHYLAXIS: 50-100mg daily
IV
OROPHARYNGEAL CANDIDIASIS, OESOPHAGEAL CANDIDIASIS, SYSTEMIC CANDISDIASIS ,VAGINAL CANDIDIASIS, CRYPTOCOCCAL MENINGITIS AND OTHER.

Top
  

Action

Found effective in several systemic fungal infections especially in candidiasis and cryptococcosis associated with immunosuppression as in AIDS or cancer therapy. Susceptible pathogens include Aspergillus spp, Blastomyced detmatitidis, Candida spp, Coccidioidies immitis, Cryptococcus neoformans and Histoplasma capsulatum.

Top
  

Interaction

Cimetidine / Plasma levels of fluconazole Cisapride / Risk of serious cardiac arrhythmias Cyclosporine / Fluconazole may cyclosporine levels in renal transplant clients with or without impaired renal function Hydrochlorothiazide / Plasma levels of fluconazole due to renal clearance Glipizide / Plasma levels of glipizide due to breakdown by the liver Glyburide / Plasma levels of glyburide due to breakdown by the liver Phenytoin / Fluconazole plasma levels of phenytoin Rifampin / Plasma levels of fluconazole due to breakdown by the liver Theophylline / Plasma levels of theophylline Tolbutamide / Plasma levels of tolbutamide due to breakdown by the liver Warfarin / PT Zidovudine / Plasma levels of AZT

Top
  

Adverse Effect & Precaution

Nausea, vomiting, abdominal pain, diarrhoea, skin rash and headache.

Precaution: Liver dysfunction, children less than 13 years
Pregnancy: Use only if potential benefit justifies the possible risk ot the foetus.
Breast Feeding: Not recommended.
Man: Use with caution

Top
  

Brands available in market
 

 

CANCAP

Ind-Swift

CAPS

150mg

10×2

478.00

CONCIZE

Indoco

TABS

50mg

50mg

40.00

Top
  


 

 

By |2022-07-20T16:42:53+00:00July 20, 2022|Uncategorized|Comments Off on Fluconazole

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