Drug
Information

   


     












Pharmacokinetics

Fluphenazine
decanoate and fluphenazine enanthate are very slowly absorbed from the
site of subcutaneous or intramuscular injection. They both gradually
release fluphenazine into the body and are therefore suitable for use as
depot injections..

The plasma half-life of fluphenazine after a single dose was 14.7 hours
in 1 patient given the hydrochloride by mouth and 14.9 and 15.3 hours in
2 patients given the hydrochloride by intramuscular injection. (1) The
half-life was 3.6 and 3.7 days in 2 patients given the enanthate
intramuscularly and 9.6 and 6.8 days in 2 patients given the decanoate
intramuscularly. Peak plasma-fluphenazine concentrations occurred
earlier in patients given fluphenazine decanoate compared with those who
received the enanthate. Fluphenazine sulphoxide and
7-hydroxyfluphenazine were identified in the urine and faeces. 

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Indication
& Dosage


 

Oral

SCHIZOPHRENIA AND OTHER PSYCHOSES, MANIA:
Initially 2.5-10mg daily in
2-3 div doses. Adjusted to 20mg/day according to response.

IM Depot

25mg IM every 2-4 weeks

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Action

In psychotics,
this drug produces calmness and reduction of aggressive hehaviour.
Initiative is reduced but intellectual capability is not.
Halllucinations and delusions disappear and patients become responsive.
Seizure threshold is reduced while serum prolactin is increased.

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Interaction

Alcohol: CNS
depression, extra-pyramidal reactions.

Aluminium Salts: Decrease efficacy. Antacids should be given 1 hour
before or 2 hours after chlorpromazine

ANticholinergics: decrease efficacy and increase the anticholinergic
side effects of chlorpromazine.

Barbiturates: Decreases efficacy.

Barbiturate anaesthetics: Increase frequency and severtiy of
neuromuscular excitation and hypotension.

Bromocriptine: Efficacy decreased by chlorpromazine.

Charcoal: Prevents absorption of chlorpromazine.

Epinephrine, Norepinephrine: Pressor effect decreased, peripheral
vasoconstrictive effect antagonised.

Lithium: Diorientation, unconsciousness and extra-pyramidal symptoms.

Meperidine: Excessive sedation and hypotension

TCAs: Serum concentration increased by chlorpromazine

Valproic acid: Efficacy potentiated.

Propranolol: Increased plasma levels of both drugs.

MAOIs: Additive orthostatic hypotensive effect.

Lab Tests: Pregnancy test: False positive rsults.

Plasma boud iodine(PBI): Increase in PBI occurs.

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Adverse
Effect & Precaution




Insomnia, dry mouth, nausea,
epigastric distress, seizures, hypotension, tachycardia.



Precaution: Epilepsy, intestinal
obstruction, cardiovascular disease, pheochromocytoma, cerebral damage.


Pregnancy: Use with caution.

Breast Feeding: Use with caution.

Man: May be given in reduced dose
 

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Brands
available in market


 














 

 

 

 

ANATENSOL

 

 

Sarabhai

INJ

25mg/ml

1ml

29.97

FLUDECAN

 

 

Sigma

INJ

25mg/ml

10x1ml

187.00

PROLINATE

 

 

Sun Pharma

INJ

25mg

1ml

25.00

 

 

 

 


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Drug Information
   

     

Pharmacokinetics

Fluphenazine decanoate and fluphenazine enanthate are very slowly absorbed from the site of subcutaneous or intramuscular injection. They both gradually release fluphenazine into the body and are therefore suitable for use as depot injections..
The plasma half-life of fluphenazine after a single dose was 14.7 hours in 1 patient given the hydrochloride by mouth and 14.9 and 15.3 hours in 2 patients given the hydrochloride by intramuscular injection. (1) The half-life was 3.6 and 3.7 days in 2 patients given the enanthate intramuscularly and 9.6 and 6.8 days in 2 patients given the decanoate intramuscularly. Peak plasma-fluphenazine concentrations occurred earlier in patients given fluphenazine decanoate compared with those who received the enanthate. Fluphenazine sulphoxide and 7-hydroxyfluphenazine were identified in the urine and faeces. 

Top
  

Indication & Dosage
 
Oral
SCHIZOPHRENIA AND OTHER PSYCHOSES, MANIA:
Initially 2.5-10mg daily in 2-3 div doses. Adjusted to 20mg/day according to response.
IM Depot
25mg IM every 2-4 weeks

Top
  

Action

In psychotics, this drug produces calmness and reduction of aggressive hehaviour. Initiative is reduced but intellectual capability is not. Halllucinations and delusions disappear and patients become responsive. Seizure threshold is reduced while serum prolactin is increased.

Top
  

Interaction

Alcohol: CNS depression, extra-pyramidal reactions.
Aluminium Salts: Decrease efficacy. Antacids should be given 1 hour before or 2 hours after chlorpromazine
ANticholinergics: decrease efficacy and increase the anticholinergic side effects of chlorpromazine.
Barbiturates: Decreases efficacy.
Barbiturate anaesthetics: Increase frequency and severtiy of neuromuscular excitation and hypotension.
Bromocriptine: Efficacy decreased by chlorpromazine.
Charcoal: Prevents absorption of chlorpromazine.
Epinephrine, Norepinephrine: Pressor effect decreased, peripheral vasoconstrictive effect antagonised.
Lithium: Diorientation, unconsciousness and extra-pyramidal symptoms.
Meperidine: Excessive sedation and hypotension
TCAs: Serum concentration increased by chlorpromazine
Valproic acid: Efficacy potentiated.
Propranolol: Increased plasma levels of both drugs.
MAOIs: Additive orthostatic hypotensive effect.
Lab Tests: Pregnancy test: False positive rsults.
Plasma boud iodine(PBI): Increase in PBI occurs.

Top
  

Adverse Effect & Precaution

Insomnia, dry mouth, nausea, epigastric distress, seizures, hypotension, tachycardia.

Precaution: Epilepsy, intestinal obstruction, cardiovascular disease, pheochromocytoma, cerebral damage.

Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: May be given in reduced dose
 

Top
  

 

 

 

 

ANATENSOL

 

 

Sarabhai

INJ

25mg/ml

1ml

29.97

FLUDECAN

 

 

Sigma

INJ

25mg/ml

10x1ml

187.00

PROLINATE

 

 

Sun Pharma

INJ

25mg

1ml

25.00

 

 

 

 

Top
 

 

 

By |2022-07-20T16:41:19+00:00July 20, 2022|Uncategorized|Comments Off on Fluphenazine

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