Drug
Information

   



      












Pharmacokinetics



After absorption it is highly
bound ot plasma proteins, there is slow excretion of the drug and its
active metabolite. Cumulation of drug occurs on daily administration.


Top

  

Indication
& Dosage


 

Oral

INSOMNIA:
15-30mg at bedtime. 


Top

  

Action

Binds to
benzodiazepine receptors in the brain and potentiates the action of GABA
in the cerebrospinal axis causing muscle relaxant  effect and
sedation. the hypnotic effect reaches its maximum on the third night.
Rebound is minimal. Residual effects may be present on the next
day. 


Top

  

Interaction



Alcohol & other CNS
depressants: Additive CNS depressant effects which continue for several
days after cesationof flurazepam therapy. Oral contraceptives,
Disulfiram & Isoniazid: Halkf-life of flurazepam prolonged reuslting
in increased pharmacologic and CNS depressant effects.

Rifampicin: Efficacy of flurazepam decreased

Somoking: CLearance is increased

Digoxin: Increased serum level of digoxina nd toxicity.

Phenytoin: Increased serum levels of phenytoin.


Top

  

Adverse
Effect & Precaution




With drawal symptoms can
occur therefore withdraw gradually. Epilepsy, physical dependence. In
hepatic, renal and cardiac dysfunction. In Children.

Pregnancy: Contraindicated.

Breast Feeding: COntraindicated

Man: May be given in reduced dose.


Top

  

Brands
available in market


 











FLURAZ

Brown & Burk
CAPS 15mg 10 14.40
NINDRAL-15

Torrent
CAPS 15mg 10 18.90




Top

 



 






 

    

   
Drug Information
   

      

Pharmacokinetics

After absorption it is highly bound ot plasma proteins, there is slow excretion of the drug and its active metabolite. Cumulation of drug occurs on daily administration.

Top
  

Indication & Dosage
 
Oral
INSOMNIA:
15-30mg at bedtime. 

Top
  

Action

Binds to benzodiazepine receptors in the brain and potentiates the action of GABA in the cerebrospinal axis causing muscle relaxant  effect and sedation. the hypnotic effect reaches its maximum on the third night. Rebound is minimal. Residual effects may be present on the next day. 

Top
  

Interaction

Alcohol & other CNS depressants: Additive CNS depressant effects which continue for several days after cesationof flurazepam therapy. Oral contraceptives, Disulfiram & Isoniazid: Halkf-life of flurazepam prolonged reuslting in increased pharmacologic and CNS depressant effects.
Rifampicin: Efficacy of flurazepam decreased
Somoking: CLearance is increased
Digoxin: Increased serum level of digoxina nd toxicity.
Phenytoin: Increased serum levels of phenytoin.

Top
  

Adverse Effect & Precaution

With drawal symptoms can occur therefore withdraw gradually. Epilepsy, physical dependence. In hepatic, renal and cardiac dysfunction. In Children.
Pregnancy: Contraindicated.
Breast Feeding: COntraindicated
Man: May be given in reduced dose.

Top
  

FLURAZ

Brown & Burk

CAPS

15mg

10

14.40

NINDRAL-15

Torrent

CAPS

15mg

10

18.90

Top
 

 

 

By |2022-07-20T16:43:00+00:00July 20, 2022|Uncategorized|Comments Off on Flurazepam

About the Author: