|
Pharmacokinetics
| Indication
& Dosage | Action
| Interacations
Precautions |
Brands available in Market
Pharmacokinetics.
Flurbiprofen, when given orally is
highly plasma protein bound (about 90- 99%). It gets metabolised in the
liver. It has a t1/2 of 4- 6 hrs.About 10% gets excreted in the urine.
Flurbiprofen enters the brain, synovial fluid and can cross the
placenta.
Indication
& Dosage
Oral
RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, ANKYLOSING SPONDYLITIS AND SIMILAR
CONDITIONS: 150-200mg in 3-4 divided doses. In severe conditions upto
300mg daily in divided doses may be given.
Oral Sustained Rel. 200mg o.d.
Inhibition of cyclo-oxygenase and reduction of prostaglandin levels. Potent inhibitor of platelet aggregation.
Flurbiprofen when used with lithium and Methotrexate, increases their toxicity. Flurbiprofen antagonises the effect of diuretics like Frusemide and Thiazides. It can delay the action of Digoxin.
Adverse
Effect & Precaution
Transient burning sensation,
local irritation, inconjunction with surgery there is an increase in
bleeding tendency of ocular tissues.
Special precaution has to be taken in patients with
history of cardiac decompensation, hypertention, pregnancy and impaired
renal function.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: May be used
ARFLUR
FDC
SR-CAPS
200mg
10
54.50
FLUROFEN
Hoechst Marion Roussel
TAB
100mg
10
29.00
FROBEN
Knoll Pharma
TAB
100mg
10
31.00
SR-TAB
200mg
10
61.79
FROBEN-FR
Knoll Pharma
GRANULES
100mg
6 sach
28.28
