Drug
Information

  



        












Pharmacokinetics
.

 

Flurbiprofen, when given orally is
highly plasma protein bound (about 90- 99%). It gets metabolised in the
liver. It has a t1/2 of 4- 6 hrs.About 10% gets excreted in the urine.
Flurbiprofen enters the brain, synovial fluid and can cross the
placenta.

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Indication
& Dosage


 

Oral

RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, ANKYLOSING SPONDYLITIS AND SIMILAR
CONDITIONS:
150-200mg in 3-4 divided doses. In severe conditions upto
300mg daily in divided doses may be given.

Oral Sustained Rel. 200mg o.d.

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Action

Inhibition of cyclo-oxygenase and reduction of
prostaglandin levels. Potent inhibitor of platelet aggregation.

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Interaction

Flurbiprofen when used with lithium and Methotrexate,
increases their toxicity. Flurbiprofen antagonises the effect of
diuretics like Frusemide and Thiazides. It can delay the action of
Digoxin.

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Adverse
Effect & Precaution




Transient burning sensation,
local irritation, inconjunction with surgery there is an increase in
bleeding tendency of ocular tissues.

Special precaution has to be taken in patients with
history of cardiac decompensation, hypertention, pregnancy and impaired
renal function.

Pregnancy: Use with caution.

Breast Feeding: Use with caution.

Man: May be used

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Brands
available in market


 


















ARFLUR

FDC

SR-CAPS

200mg

10

54.50

FLUROFEN

Hoechst Marion Roussel

TAB

100mg

10

29.00

FROBEN

Knoll Pharma

TAB

100mg

10

31.00

SR-TAB

200mg

10

61.79

FROBEN-FR

Knoll Pharma

GRANULES

100mg

6 sach

28.28



Top

    




 






 

     

   
Drug Information
  

        

Pharmacokinetics.
 
Flurbiprofen, when given orally is highly plasma protein bound (about 90- 99%). It gets metabolised in the liver. It has a t1/2 of 4- 6 hrs.About 10% gets excreted in the urine. Flurbiprofen enters the brain, synovial fluid and can cross the placenta.

Top
  

Indication & Dosage
 
Oral
RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, ANKYLOSING SPONDYLITIS AND SIMILAR CONDITIONS:
150-200mg in 3-4 divided doses. In severe conditions upto 300mg daily in divided doses may be given.
Oral Sustained Rel. 200mg o.d.

Top
  

Action

Inhibition of cyclo-oxygenase and reduction of prostaglandin levels. Potent inhibitor of platelet aggregation.

Top
  

Interaction

Flurbiprofen when used with lithium and Methotrexate, increases their toxicity. Flurbiprofen antagonises the effect of diuretics like Frusemide and Thiazides. It can delay the action of Digoxin.

Top
  

Adverse Effect & Precaution

Transient burning sensation, local irritation, inconjunction with surgery there is an increase in bleeding tendency of ocular tissues.

Special precaution has to be taken in patients with history of cardiac decompensation, hypertention, pregnancy and impaired renal function.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: May be used

Top
  

ARFLUR

FDC

SR-CAPS

200mg

10

54.50

FLUROFEN

Hoechst Marion Roussel

TAB

100mg

10

29.00

FROBEN

Knoll Pharma

TAB

100mg

10

31.00

SR-TAB

200mg

10

61.79

FROBEN-FR

Knoll Pharma

GRANULES

100mg

6 sach

28.28

Top
    

 

 

By |2022-07-20T16:43:00+00:00July 20, 2022|Uncategorized|Comments Off on Flurbiprofen

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