Drug Information

  


   












Pharmacokinetics

 


Flutamide is reported to
be rapidly and completely absorbed from the gastrointestinal tract with
peak plasma concentrations occurring 1 hour after a dose. It is rapidly
and extensively metabolised; the major metabolite (2-hydroxyflutamide)
possesses anti-androgenic properties. The half-life of the metabolite is
about 6 hours. Both flutamide and 2-hydroxyflutamide are more than 90%
bound to plasma proteins. Excretion is predominantly in the urine with
only minor amounts appearing in the faeces.

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Indication
& Dosage


 

Oral

PROSTATIC CANCER: 250mg t.i.d.

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Action




Flutamide is a nonsteroidal ‘pure’
antiandrogen since it has no toher hormonal activity. It acts directly
on the target tissues either by blocking androgen uptake or by
inhibiting cytoplasmic and nuclear binding cf androgen. In animal
studies flutamide reduced prostate and seminal vesicle weights and
prevented androgen-stimulated hypertrophy of accessory sex tissues.

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Interaction

 

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Adverse
Effect & Precaution




Nausea, epigastric
distress, vomiting diarhoea, gynaecomastia, galactorhoea, gynaecomastia,
galactorhoea, hepatitis, breast tenderness, insomnia.



Precaution: Liver function tests to be done perodically. Water retention
may occur in cardiac disease. Water retention may occur in cardiac
disease. Long term administration.

Pregnancy: Use with caution.

Breast Feeding: Use with caution.

Man: Use with Caution.

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Brands
available in market


 

















 

 

 

 

CYTOMID-250

 

 

Cipla

TAB

250mg

10

100.00

DROGENIL

 

 

Fulford

TAB

250mg

30

2210.90

FLUTACARE

 

 

Criticare

TAB

250mg

5

115.07

PLUTAMIDE

 

 

Torrent

TAB

250mg

10

435.00

PROSTAMID

 

  

BDH

TAB

250mg

10

115.75


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Drug Information
  

   

Pharmacokinetics
 

Flutamide is reported to be rapidly and completely absorbed from the gastrointestinal tract with peak plasma concentrations occurring 1 hour after a dose. It is rapidly and extensively metabolised; the major metabolite (2-hydroxyflutamide) possesses anti-androgenic properties. The half-life of the metabolite is about 6 hours. Both flutamide and 2-hydroxyflutamide are more than 90% bound to plasma proteins. Excretion is predominantly in the urine with only minor amounts appearing in the faeces.

Top
   

Indication & Dosage
 
Oral
PROSTATIC CANCER: 250mg t.i.d.

Top
   

Action

Flutamide is a nonsteroidal ‘pure’ antiandrogen since it has no toher hormonal activity. It acts directly on the target tissues either by blocking androgen uptake or by inhibiting cytoplasmic and nuclear binding cf androgen. In animal studies flutamide reduced prostate and seminal vesicle weights and prevented androgen-stimulated hypertrophy of accessory sex tissues.

Top
   

Interaction

 

Top
   

Adverse Effect & Precaution

Nausea, epigastric distress, vomiting diarhoea, gynaecomastia, galactorhoea, gynaecomastia, galactorhoea, hepatitis, breast tenderness, insomnia.

Precaution: Liver function tests to be done perodically. Water retention may occur in cardiac disease. Water retention may occur in cardiac disease. Long term administration.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: Use with Caution.

Top
   

 

 

 

 

CYTOMID-250

 

 

Cipla

TAB

250mg

10

100.00

DROGENIL

 

 

Fulford

TAB

250mg

30

2210.90

FLUTACARE

 

 

Criticare

TAB

250mg

5

115.07

PLUTAMIDE

 

 

Torrent

TAB

250mg

10

435.00

PROSTAMID

 

  

BDH

TAB

250mg

10

115.75

Top
  

 

 

By |2022-07-20T16:42:59+00:00July 20, 2022|Uncategorized|Comments Off on Flutamide

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