|
Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interacations
Precautions |
Brands available in Market
Pharmacokinetics
Flutamide is reported to
be rapidly and completely absorbed from the gastrointestinal tract with
peak plasma concentrations occurring 1 hour after a dose. It is rapidly
and extensively metabolised; the major metabolite (2-hydroxyflutamide)
possesses anti-androgenic properties. The half-life of the metabolite is
about 6 hours. Both flutamide and 2-hydroxyflutamide are more than 90%
bound to plasma proteins. Excretion is predominantly in the urine with
only minor amounts appearing in the faeces.
Indication
& Dosage
Oral
PROSTATIC CANCER: 250mg t.i.d.
Action
Flutamide is a nonsteroidal ‘pure’
antiandrogen since it has no toher hormonal activity. It acts directly
on the target tissues either by blocking androgen uptake or by
inhibiting cytoplasmic and nuclear binding cf androgen. In animal
studies flutamide reduced prostate and seminal vesicle weights and
prevented androgen-stimulated hypertrophy of accessory sex tissues.
Adverse
Effect & Precaution
Nausea, epigastric
distress, vomiting diarhoea, gynaecomastia, galactorhoea, gynaecomastia,
galactorhoea, hepatitis, breast tenderness, insomnia.
Precaution: Liver function tests to be done perodically. Water retention
may occur in cardiac disease. Water retention may occur in cardiac
disease. Long term administration.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: Use with Caution.
CYTOMID-250
Cipla
TAB
250mg
10
100.00
DROGENIL
Fulford
TAB
250mg
30
2210.90
FLUTACARE
Criticare
TAB
250mg
5
115.07
PLUTAMIDE
Torrent
TAB
250mg
10
435.00
PROSTAMID
BDH
TAB
250mg
10
115.75
