Drug Information

 


    












Pharmacokinetics

 

Fluticasone propionate is
poorly absorbed from the gastrointestinal tract and undergoes extensive
first-pass metabolism; oral bioavailability is reported to be only about
1%.

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Indication
& Dosage


 

Topical skin

CONTACT DERMATITIS, ATOPIC DERMATITIS, ECZEMAS, LICHEN PLANUS, LICHEN
SIMPLEX CHRONICUS, PSORIASIS, SEBORRHEIC DERMATITIS, NODULAR PRURIGO,
INSECT BITES AND STINGS, 1ST AND 2ND DEGREE LOCALISED BURNS, SUNBURN,
CHRONIC DISCOLDD LUPUS ERYTHEMATOSUS: 0.05% w/w cream Apply as a thin
film to the affected areas twice daily. Rub gently.

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Action




Negligible oral bioavailability even
when swallowed. Otherwise fluticasone has the typical activity profile
of a glucocorticoid. It exerts local anti-inflammatory effect when
applied on in bronchial asthma, fluticasone improves control of asthma
and lung function. Amont the topically active steroids fluticasone has
ha high therapeutic index which makes it very usefulin
steroid-responsive dermatoses. Absorption frm, the skin is slow an there
is little metabolism in suit.

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Interaction



None Reported.

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Adverse
Effect & Precaution



Pruritus,
hypertrichosis, burning, dryness, numbness of fingers, skin atrophic,
hyperpigmentation, Cushing’s syndrome.



Precaution: Children concomitant skin infections.

Pregnancy: Use with caution.

Breast Feeding: Use with caution.

Man: May be used.

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Brands
available in market


 













FLUTIVATE

Glaxo Pharma
CREAM 0.05% 5g 32.04
MOLIDREM

Smithkline Beecham
CREAM 0.05% w/w 10g 60.00
ZOFLUT

Cipla
CREAM 0.05% w/w 5g 30.00




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Drug Information
 

    

Pharmacokinetics
 
Fluticasone propionate is poorly absorbed from the gastrointestinal tract and undergoes extensive first-pass metabolism; oral bioavailability is reported to be only about 1%.

Top
   

Indication & Dosage
 
Topical skin
CONTACT DERMATITIS, ATOPIC DERMATITIS, ECZEMAS, LICHEN PLANUS, LICHEN SIMPLEX CHRONICUS, PSORIASIS, SEBORRHEIC DERMATITIS, NODULAR PRURIGO, INSECT BITES AND STINGS, 1ST AND 2ND DEGREE LOCALISED BURNS, SUNBURN, CHRONIC DISCOLDD LUPUS ERYTHEMATOSUS: 0.05% w/w cream Apply as a thin film to the affected areas twice daily. Rub gently.

Top
   

Action

Negligible oral bioavailability even when swallowed. Otherwise fluticasone has the typical activity profile of a glucocorticoid. It exerts local anti-inflammatory effect when applied on in bronchial asthma, fluticasone improves control of asthma and lung function. Amont the topically active steroids fluticasone has ha high therapeutic index which makes it very usefulin steroid-responsive dermatoses. Absorption frm, the skin is slow an there is little metabolism in suit.

Top
   

Interaction

None Reported.

Top
   

Adverse Effect & Precaution

Pruritus, hypertrichosis, burning, dryness, numbness of fingers, skin atrophic, hyperpigmentation, Cushing’s syndrome.

Precaution: Children concomitant skin infections.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: May be used.

Top
   

FLUTIVATE

Glaxo Pharma

CREAM

0.05%

5g

32.04

MOLIDREM

Smithkline Beecham

CREAM

0.05% w/w

10g

60.00

ZOFLUT

Cipla

CREAM

0.05% w/w

5g

30.00

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By |2022-07-20T16:41:45+00:00July 20, 2022|Uncategorized|Comments Off on Fluticasone

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