Pharmacokinetics

The loop
agents are rapidly absorbed and handled by renal excretion and
secretion. Duration of effect is for 3 to 4 hrs. The diuretic inhibits
primarily the absorption of Sodium and Chloride in both the proximal and
distal tubules and in the loop of Henle. The onset of diuresis is within
1 hour. The peak effect occurs within the first and second hour. The
duration of action is 6-8 hours. The duration of diuretic effect is
approximately 2 hours.

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Indication
& Dosage




Oral

MILD TO MODERATE HYPERTENSION:
40-80mg once or twice daily.

CARDIAC, PULMONARY, RENAL HEPATIC AND CEREBRAL OEDEMA: 20-80mg as a single
dose daily or on alternate days. Children: 1-2mg/kg/day as single dose.

IM/IV

CARDIAC, PULMONARY, RENAL HEPATIC AND CEREBRAL OEDEMA:


20-80mg/day IM or slow IV (1-2 min). 

Children: 1mg/kg/day IM OR IV. Max daily dose 20mg

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Action



Frusemide inhibits reabsorption
of sodium and chloride mainly in the medullary portionof hte ascending
limb of the Loop o Henle. Excretion of K+ and ammonia is also increased
while uric acid excretion is reduced. It increases plasma renin levels and
secondary hyperaldosteronism may result. Frusemide reduces BP in
hypertensives as well as in normotensives. It reduces pulmonary oedema
before diuresis has set in.

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Interaction

It may increase
the nephrotoxicity of cephalosporin and aminoglycosides. Phenytoin and
indomethacin decreases the effectiveness of frusemide. Analgesics may
reduce the natriuretic effect. Frusemide enhances muscle relaxants.

TOP

 
 
  

Adverse Effect &
Precaution

 

Fluid and Electrolyte
imbalance, nausea, anotrexia, vomiting, epigastric distress, fatigue,
weakness,  dizziness, fatigue, weakness, muscle cramps, drowsiness,
dizziness, paraesthesia, hyperuricaemia, decrease in tolerance to
carbohydrates and deafness (transient). Hearing impairment and deafness
are usually reversible.



Allergies : Allergic reaction
to frusemide may occur. Pregnancy: In general, diuretics are not useful
for normal edema of feet and hands that occurs during pregnancy. Diuretics
should not be taken during pregnancy. Breast-feeding : Frusemide passes
into breast milk. Older adults: Dizziness, light-headedness, or signs of
hypokalemia may be more likely to occur in the elderly, who are more
sensitive to the effects of this drug. Elderly patients may also be more
likely to develop thrombii.

Pregnancy: Use with caution.

Breast Feeding: Use with caution.

Man: Use with Caution.

TOP

 
 
 
  

Brands
available in market























 

DIUCONTIN-K
CONTINUS

 

Modi
Mundi Pharma

TAB

40mg

10

31.70

TAB

20mg

10

16.45

DIUCONTIN-K
TM CONTINUS

 

 

Modi
Mundi Pharma

TAB

20mg

10

16.45

FRUSENEX

 

 

Geno

TAB

40mg

10

4.20

TAB

100mg

10

10.11

LASIX

 

 

Hoechst
Marion Roussel

TAB

40mg

25×10

83.32

INJ

20mg/ml

10x2ml

24.66

LASIX
HIGH DOSE

 

 

Hoechst
Marion Roussel

TAB

500mg

10

28.31

INJ

250mg/25ml

5x25ml

35.33

SALINEX

 

 

IDPL

TAB

40mg

10

2.69

 

 


TOP

 
 


 






 

  

 

    

Pharmacokinetics

The loop agents are rapidly absorbed and handled by renal excretion and secretion. Duration of effect is for 3 to 4 hrs. The diuretic inhibits primarily the absorption of Sodium and Chloride in both the proximal and distal tubules and in the loop of Henle. The onset of diuresis is within 1 hour. The peak effect occurs within the first and second hour. The duration of action is 6-8 hours. The duration of diuretic effect is approximately 2 hours.

TOP
   

Indication & Dosage

Oral
MILD TO MODERATE HYPERTENSION:
40-80mg once or twice daily.
CARDIAC, PULMONARY, RENAL HEPATIC AND CEREBRAL OEDEMA: 20-80mg as a single dose daily or on alternate days. Children: 1-2mg/kg/day as single dose.

IM/IV
CARDIAC, PULMONARY, RENAL HEPATIC AND CEREBRAL OEDEMA:

20-80mg/day IM or slow IV (1-2 min). 
Children: 1mg/kg/day IM OR IV. Max daily dose 20mg

TOP
   
 

Action

Frusemide inhibits reabsorption of sodium and chloride mainly in the medullary portionof hte ascending limb of the Loop o Henle. Excretion of K+ and ammonia is also increased while uric acid excretion is reduced. It increases plasma renin levels and secondary hyperaldosteronism may result. Frusemide reduces BP in hypertensives as well as in normotensives. It reduces pulmonary oedema before diuresis has set in.

TOP
   

Interaction

It may increase the nephrotoxicity of cephalosporin and aminoglycosides. Phenytoin and indomethacin decreases the effectiveness of frusemide. Analgesics may reduce the natriuretic effect. Frusemide enhances muscle relaxants.

TOP
   
  

Adverse Effect & Precaution
 
Fluid and Electrolyte imbalance, nausea, anotrexia, vomiting, epigastric distress, fatigue, weakness,  dizziness, fatigue, weakness, muscle cramps, drowsiness, dizziness, paraesthesia, hyperuricaemia, decrease in tolerance to carbohydrates and deafness (transient). Hearing impairment and deafness are usually reversible.

Allergies : Allergic reaction to frusemide may occur. Pregnancy: In general, diuretics are not useful for normal edema of feet and hands that occurs during pregnancy. Diuretics should not be taken during pregnancy. Breast-feeding : Frusemide passes into breast milk. Older adults: Dizziness, light-headedness, or signs of hypokalemia may be more likely to occur in the elderly, who are more sensitive to the effects of this drug. Elderly patients may also be more likely to develop thrombii.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: Use with Caution.

TOP
   
    

Brands available in market

 

DIUCONTIN-K CONTINUS

 

Modi Mundi Pharma

TAB

40mg

10

31.70

TAB

20mg

10

16.45

DIUCONTIN-K TM CONTINUS

 

 

Modi Mundi Pharma

TAB

20mg

10

16.45

FRUSENEX

 

 

Geno

TAB

40mg

10

4.20

TAB

100mg

10

10.11

LASIX

 

 

Hoechst Marion Roussel

TAB

40mg

25×10

83.32

INJ

20mg/ml

10x2ml

24.66

LASIX HIGH DOSE

 

 

Hoechst Marion Roussel

TAB

500mg

10

28.31

INJ

250mg/25ml

5x25ml

35.33

SALINEX

 

 

IDPL

TAB

40mg

10

2.69

 

 

TOP
   

 

 

By |2022-07-20T16:43:08+00:00July 20, 2022|Uncategorized|Comments Off on Frusemide

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