Although furazolidone has been considered to be largely unabsorbed when administered orally, the occurrence of systemic adverse effects and coloured metabolites in the urine suggest that this may not be the case. Rapid and extensive metabolism, possibly in the intestine, has been proposed.
BACTERIAL GUT INFECTIONS, FOOD POISONING, BACILLARY DYSENTERY, DIARRHOEAS : 100mg q.i.d Children: 5mg/kg/day in 4 div doses.
TYPHOID: Adult: 200mg 3-4 times daily. Children: 7.5-10mg/kg/day in 4 div doses. Maximum durationis 14 days.
Broad antibacterial spectrum. A Susceptible organisms include E.coil, staphylococci, salmonella, shigella, proteus, vibrio cholerae, and giardia lamblia. Bactericidal by interference with bacterial enzyme systems.
reaction has been reported in patients taking alcohol while on
furazolidone therapy; alcohol should be avoided during, and for a short
period after, treatment with furazolidone.
Furazolidone is an MAOI and the cautions advised for these drugs regarding the concomitant administration of other drugs, especially indirect acting sympathomimetic amines, and the consumption of food and drink containing tyramine, should be observed.However, there appear to be no reports of hypertensive crises in patients receiving furazolidone and it has been suggested that, since furazolidone inhibits monoamine oxidase gradually over several days, the risks are small if treatment is limited to a 5-day course. Toxic psychosis has been reported in a patient receiving furazolidone and amitriptyline.
Effect & Precaution.
Nausea, vomiting, dizziness, headache.
Precaution: Urine colour turns orange
Pregnancy: Safety not established.
Breat Feeding: Safety not establishe.
Man: Use with caution.
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