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Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interacations
Precautions |
Brands available in Market
Pharmacokinetics.
Although furazolidone has
been considered to be largely unabsorbed when administered orally, the
occurrence of systemic adverse effects and coloured metabolites in the
urine suggest that this may not be the case. Rapid and extensive
metabolism, possibly in the intestine, has been proposed.
Indication
& Dosage
Oral
BACTERIAL GUT INFECTIONS, FOOD POISONING, BACILLARY DYSENTERY,
DIARRHOEAS : 100mg q.i.d Children: 5mg/kg/day in 4 div doses.
TYPHOID: Adult: 200mg 3-4 times daily. Children: 7.5-10mg/kg/day in 4
div doses. Maximum durationis 14 days.
Action
Broad antibacterial spectrum.
A Susceptible organisms include E.coil, staphylococci, salmonella,
shigella, proteus, vibrio cholerae, and giardia lamblia. Bactericidal by
interference with bacterial enzyme systems.
Interaction
A disulfiram-like
reaction has been reported in patients taking alcohol while on
furazolidone therapy; alcohol should be avoided during, and for a short
period after, treatment with furazolidone.
Furazolidone is an MAOI and the cautions advised for these drugs
regarding the concomitant administration of other drugs, especially
indirect acting sympathomimetic amines, and the consumption of food and
drink containing tyramine, should be observed.However, there appear to
be no reports of hypertensive crises in patients receiving furazolidone
and it has been suggested that, since furazolidone inhibits monoamine
oxidase gradually over several days, the risks are small if treatment is
limited to a 5-day course. Toxic psychosis has been reported in a
patient receiving furazolidone and amitriptyline.
Adverse
Effect & Precaution.
Nausea, vomiting, dizziness,
headache.
Precaution: Urine colour turns orange
Pregnancy: Safety not established.
Breat Feeding: Safety not establishe.
Man: Use with caution.
Brands
available in market
