HYPERLIPIDAEMIAS: 600mg twice daily in the morning and evening 30 mins before meals.
Reduces serum triglycerides(TG) and increases HDL cholesterol. LDL cholesterol is reduced to a greater extent thean by clofibrate. VLDL synthesis is reduced while its catabolism is increased. Incidence of coronary heart disease has been reduced. Gemfibrozil has no effect on plasma fibrinogen or glucose tolerance.
Oral anticoagulants: Effficacy of oral anticoagulants enhanced requiring adjustment in their dosage.
Lovastatin: Rhabdomyolysis (mositis) has occured as early as 3 weeks after combined therapy.
Effect & Precaution
Nausea, diarhoea, abdominal pain, dyspepsia, myositis, fatigue, skin rash, cholelithiasis, weight gain, leucopenia, alopecia, blurred vision.
Precaution: To monitor blood count, liver function and lipid profile before starting the therapy and to repeat these test periodically. Children, inadequate response after 3 months.
Breast Feeding: Contraindicated.
Man: Use with caution.
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