Drug Information

  




Gemfibrozil


 














 

Pharmacokinetics

 

It is completely absorbed form gastrointestinal tract.

Top  

 

Indication
& Dosage


 


Oral

HYPERLIPIDAEMIAS:
600mg twice daily in the morning and evening 30 mins
before meals.

Top   

 

Action

Reduces serum triglycerides(TG) and increases HDL cholesterol. LDL
cholesterol is reduced to a greater extent thean by clofibrate. VLDL
synthesis is reduced while its catabolism is increased. Incidence of
coronary heart disease has been reduced. Gemfibrozil has no effect on
plasma fibrinogen or glucose tolerance.

Top  

  

Interaction



Oral anticoagulants: Effficacy of oral anticoagulants enhanced requiring
adjustment in their dosage.

Lovastatin: Rhabdomyolysis (mositis) has occured as early as 3 weeks
after combined therapy.

Top    

 

Adverse
Effect & Precaution



Nausea, diarhoea, abdominal pain, dyspepsia, myositis, fatigue,
skin rash, cholelithiasis, weight gain, leucopenia, alopecia, blurred
vision.



Precaution: To monitor blood count,
liver function and lipid profile before starting the therapy and to
repeat these test periodically. Children, inadequate response after 3
months.

Pregnancy: Contraindicated.

Breast Feeding: Contraindicated.

Man: Use with caution.

Top

   

Brands
available in market


 
























 


GEMPAR


Cadila Pharma


CAPS


300mg


10


73.20


LIPIGEM


Torrent


CAPS


300mg


10


69.90


LIPIZYL


Nicholas-Piramal


CAPS


300mg


20


70.00


LOPID


Parke-Davis


CAPS


300mg


10


9.75


CAPS


600mg


10


193.50


LOSTEROL


Gufic


CAPS


300mg


2×15


180.00


NORMOLIP


Sun Pharma


CAPS


300mg


10


95.00


Top  




 





 

 

 

    
Drug Information
  


Gemfibrozil
 

 
Pharmacokinetics
 
It is completely absorbed form gastrointestinal tract.

Top  
 

Indication & Dosage
 
Oral
HYPERLIPIDAEMIAS:
600mg twice daily in the morning and evening 30 mins before meals.

Top   
 

Action

Reduces serum triglycerides(TG) and increases HDL cholesterol. LDL cholesterol is reduced to a greater extent thean by clofibrate. VLDL synthesis is reduced while its catabolism is increased. Incidence of coronary heart disease has been reduced. Gemfibrozil has no effect on plasma fibrinogen or glucose tolerance.

Top  
  

Interaction

Oral anticoagulants: Effficacy of oral anticoagulants enhanced requiring adjustment in their dosage.
Lovastatin: Rhabdomyolysis (mositis) has occured as early as 3 weeks after combined therapy.

Top    
 

Adverse Effect & Precaution

Nausea, diarhoea, abdominal pain, dyspepsia, myositis, fatigue, skin rash, cholelithiasis, weight gain, leucopenia, alopecia, blurred vision.

Precaution: To monitor blood count, liver function and lipid profile before starting the therapy and to repeat these test periodically. Children, inadequate response after 3 months.
Pregnancy: Contraindicated.
Breast Feeding: Contraindicated.
Man: Use with caution.

Top
   

Brands available in market
 

 

GEMPAR

Cadila Pharma

CAPS

300mg

10

73.20

LIPIGEM

Torrent

CAPS

300mg

10

69.90

LIPIZYL

Nicholas-Piramal

CAPS

300mg

20

70.00

LOPID

Parke-Davis

CAPS

300mg

10

9.75

CAPS

600mg

10

193.50

LOSTEROL

Gufic

CAPS

300mg

2×15

180.00

NORMOLIP

Sun Pharma

CAPS

300mg

10

95.00

Top  

 

 

By |2022-07-20T16:43:00+00:00July 20, 2022|Uncategorized|Comments Off on Gemfibrozil

About the Author: