Drug Information

   





Gliclazide



    












 

Pharmacokinetics

 

Gliclazide belongs to the group of
intermediate acting hypoglycaemic agents. It is rapidly absorbed from
the GIT, and is metabolised in the liver. It appears in the blood within
1-2 hrs. It is extensively plasma protein bound ( more than 90%). Peak
level is achieved in 4-6 hrs. The plasma t 1/2 is 8-12 hrs and its
duration of action is 12 hrs.

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Indication
& Dosage


 


Oral

NONINSULIN-DEPENDENT DIABETES MELLITUS: 40-80mg/day increasing upto
320mg/day in div doses before breakdfast and evening meal. Elderly,
renal or hepatic damage: Start with lower doses and increase with care.

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Action

Stimulates insulin secretion by pancreatic beta cells. In the
long-term reduces hepatic gluconeogenesis, and increases insulin effects
by acting at receptor or post-receptor sites. Inhibits platelet
aggregation and increases fibrinolysis.

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Interaction

The hypoglycaemic effect of gliclazide is potentiated
by Phenylbutazone, aspirin, clofibrate, sulphonamides, oral
anticoagulants and MAO inhibitors. Rifampicin, barbiturates, alcohol,
diuretics, diazoxide, glucocorticoids,estrogens and sympathomimietic
drugs antagonise the hypoglycaemic action of gliclazide.

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Adverse
Effect & Precaution




Skin rash, urticaria, blood
dyscrasias, hypoglycaemia.

Precaution is to be taken in hypoglycaemia and
stress. During metabolic stress insulin may be needed in addition.
Extreme care should be taken during transfer of drug therapy.

Pregnancy: Contraindicated.

Breast Feeding: Use with caution/

Man: Use with caution.

Top 

 
  

Brands
available in market


 














































 



DIABEND


Bal Pharma


TAB


80mg


10


30.00


DIAMICRON


Serdia


TAB


80mg


10


65.02


DIANORM


Micro Labs


TAB


80mg


6


22.80


DIASAFE


Sertec


TAB


80mg


10


29.00


DIAZIDE


Inga


TAB


20mg


10


29.75


TABS


80mg


10


29.75


FASKON


Dee Pharma


TAB


80mg


10


28.50


GLICLAZ


Khandelwal


TAB


80mg


10


28.00


GLIDIET


Modi Mundi Pharma


TAB


80mg


10


28.00


GLIX


Indipharma


TABS


80mg


10


28.50


GLIZID


Panacea


TAB


80mg


10


27.50


TAB


40mg


10


15.00


GLUCOZID


Medley


TAB


80mg


10


28.60


GLYCIGON


Aristo


TAB


80mg


10


28.17


GLYCOR


USV


TAB


80mg


10


23.65


RECLIDE


DR. Reddy’s


TAB


80mg


10


29.97


TAB


40mg


10


17.64


SEMI DIABEND


Bal Pharma


TAB


40mg


10


18.00


SEMI-GYCIGON


Aristo


TAB


40mg


10


19.12


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Drug Information
   


Gliclazide
    

 
Pharmacokinetics
 
Gliclazide belongs to the group of intermediate acting hypoglycaemic agents. It is rapidly absorbed from the GIT, and is metabolised in the liver. It appears in the blood within 1-2 hrs. It is extensively plasma protein bound ( more than 90%). Peak level is achieved in 4-6 hrs. The plasma t 1/2 is 8-12 hrs and its duration of action is 12 hrs.

Top 
 

Indication & Dosage
 
Oral
NONINSULIN-DEPENDENT DIABETES MELLITUS: 40-80mg/day increasing upto 320mg/day in div doses before breakdfast and evening meal. Elderly, renal or hepatic damage: Start with lower doses and increase with care.

Top 
 

Action

Stimulates insulin secretion by pancreatic beta cells. In the long-term reduces hepatic gluconeogenesis, and increases insulin effects by acting at receptor or post-receptor sites. Inhibits platelet aggregation and increases fibrinolysis.

Top 
 

Interaction

The hypoglycaemic effect of gliclazide is potentiated by Phenylbutazone, aspirin, clofibrate, sulphonamides, oral anticoagulants and MAO inhibitors. Rifampicin, barbiturates, alcohol, diuretics, diazoxide, glucocorticoids,estrogens and sympathomimietic drugs antagonise the hypoglycaemic action of gliclazide.

Top
  

Adverse Effect & Precaution

Skin rash, urticaria, blood dyscrasias, hypoglycaemia.

Precaution is to be taken in hypoglycaemia and stress. During metabolic stress insulin may be needed in addition. Extreme care should be taken during transfer of drug therapy.
Pregnancy: Contraindicated.
Breast Feeding: Use with caution/
Man: Use with caution.

Top 
 
  

 

DIABEND

Bal Pharma

TAB

80mg

10

30.00

DIAMICRON

Serdia

TAB

80mg

10

65.02

DIANORM

Micro Labs

TAB

80mg

6

22.80

DIASAFE

Sertec

TAB

80mg

10

29.00

DIAZIDE

Inga

TAB

20mg

10

29.75

TABS

80mg

10

29.75

FASKON

Dee Pharma

TAB

80mg

10

28.50

GLICLAZ

Khandelwal

TAB

80mg

10

28.00

GLIDIET

Modi Mundi Pharma

TAB

80mg

10

28.00

GLIX

Indipharma

TABS

80mg

10

28.50

GLIZID

Panacea

TAB

80mg

10

27.50

TAB

40mg

10

15.00

GLUCOZID

Medley

TAB

80mg

10

28.60

GLYCIGON

Aristo

TAB

80mg

10

28.17

GLYCOR

USV

TAB

80mg

10

23.65

RECLIDE

DR. Reddy’s

TAB

80mg

10

29.97

TAB

40mg

10

17.64

SEMI DIABEND

Bal Pharma

TAB

40mg

10

18.00

SEMI-GYCIGON

Aristo

TAB

40mg

10

19.12

Top 
 

 

 

By |2022-07-20T16:41:41+00:00July 20, 2022|Uncategorized|Comments Off on Gliclazide

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