Drug Information

   





Glipizide



      











 

Pharmacokinetics

Glipizide belongs to the group of long acting
hypoglycaemic agents. It is rapidly absorbed from the GIT, and is
metabolized in the liver. It appears in the blood within 1-2 hrs. It is
extensively plasma protein bound ( more than 90%). Peak level is
achieved in 4-6 hrs. The plasma t 1/2 is 4 hrs and its duration of
action is 16- 24 hrs.

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Indication
& Dosage


 

NONINSULIN-DEPENDENT DIABETES MELLITUS:
Start with 2.5mg/day given
30 min before breakfast. Dose may be increased as required over 2-4
weeks upto 20mg/day givenin 2 div doses 30 mins before breakfast and
dinner. Once glycaemic control is achieved maintenance dose should be
given only once ad day. Patients on insulin can be trasferred to
glipizide; those receiving less than 20 units a day can receive usual
doses of glipizide after stopping insulin. In those recieving more than
20 units of insulin, halve the dose and add glipizide at usual doses.
Monitor blood glucose during transition. Elderly: Start at low doses and
build up carefully.

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Action

Stimulates insulin release in response to a meal, but does not
increase fasting insulin levels. Reduces gluconeogenesis, Increases
insulin sensitivity and glucose uptake.

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Interaction

The hypoglycaemic action of glipizide is enhanced by
alcohol, sulphonamides, tri-methoprim, salicylates and NSAID’s.
Non-selective beta-blockers can mask the hypoglycaemic effect of
glipizide.

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Adverse
Effect & Precaution




Nausea, vomiting, skin rash,
headache, itching, thrombocytopenia, drowsiness allergic reactions,
hypoglycaemia.

Precautions are to be taken in
hypoglycaemia, stress,
thyroid impairment, gastroenteritis and in conditions where there is
caloric deprivation.

Pregnancy: Contraindicated.

Breast Feeding: Use with caution.

Man: Use with caution.

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Brands
available in market


 




























 


DIACON


Bal Pharma


TAB


5mg


10


8.69


DIBIZIDE


Micro Labs


TABS


5mg


10


8.49


GLIBETIC


La Pharma


TAB


5mg


10


7.00


GLIDE


Franco-Indian


TAB


5mg


10


8.08


GLUCOLIP


Wallace


TAB


5mg


10


8.50


GLUCOTROL


Jenburkt


TAB


5mg


20


18.30


GLYNASE


USV


TAB


5mg


10


9.04


SEMI TAB


2.5mg


10


5.00


GLYTOP SR


Sertec


SR TAB


5mg


10


11.95


M-DIAB


Dominion


TAB


2.5mg


10


3.84


TAB


5mg


10


6.32


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Drug Information
   


Glipizide
      

 
Pharmacokinetics

Glipizide belongs to the group of long acting hypoglycaemic agents. It is rapidly absorbed from the GIT, and is metabolized in the liver. It appears in the blood within 1-2 hrs. It is extensively plasma protein bound ( more than 90%). Peak level is achieved in 4-6 hrs. The plasma t 1/2 is 4 hrs and its duration of action is 16- 24 hrs.

Top
           

Indication & Dosage
 
NONINSULIN-DEPENDENT DIABETES MELLITUS: Start with 2.5mg/day given 30 min before breakfast. Dose may be increased as required over 2-4 weeks upto 20mg/day givenin 2 div doses 30 mins before breakfast and dinner. Once glycaemic control is achieved maintenance dose should be given only once ad day. Patients on insulin can be trasferred to glipizide; those receiving less than 20 units a day can receive usual doses of glipizide after stopping insulin. In those recieving more than 20 units of insulin, halve the dose and add glipizide at usual doses. Monitor blood glucose during transition. Elderly: Start at low doses and build up carefully.

Top
  

Action

Stimulates insulin release in response to a meal, but does not increase fasting insulin levels. Reduces gluconeogenesis, Increases insulin sensitivity and glucose uptake.

Top

Interaction

The hypoglycaemic action of glipizide is enhanced by alcohol, sulphonamides, tri-methoprim, salicylates and NSAID’s. Non-selective beta-blockers can mask the hypoglycaemic effect of glipizide.

Top
           

Adverse Effect & Precaution

Nausea, vomiting, skin rash, headache, itching, thrombocytopenia, drowsiness allergic reactions, hypoglycaemia.

Precautions are to be taken in hypoglycaemia, stress, thyroid impairment, gastroenteritis and in conditions where there is caloric deprivation.
Pregnancy: Contraindicated.
Breast Feeding: Use with caution.
Man: Use with caution.

Top
   

 

DIACON

Bal Pharma

TAB

5mg

10

8.69

DIBIZIDE

Micro Labs

TABS

5mg

10

8.49

GLIBETIC

La Pharma

TAB

5mg

10

7.00

GLIDE

Franco-Indian

TAB

5mg

10

8.08

GLUCOLIP

Wallace

TAB

5mg

10

8.50

GLUCOTROL

Jenburkt

TAB

5mg

20

18.30

GLYNASE

USV

TAB

5mg

10

9.04

SEMI TAB

2.5mg

10

5.00

GLYTOP SR

Sertec

SR TAB

5mg

10

11.95

M-DIAB

Dominion

TAB

2.5mg

10

3.84

TAB

5mg

10

6.32

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By |2022-07-20T16:41:17+00:00July 20, 2022|Uncategorized|Comments Off on Glipizide

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