Drug Information

  






Glyceryl
Trinitrate





 











 

Pharmacokinetics



Administered by sublingual route it is absorbed rapidly.

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Indication
& Dosage
 

Sublingual

PROPHYLAXIS OR RELIEF OF ANGINAL ATTACK:
0.5mg ever 3 min
until pain subsides. Prevention: 0.5mg sublingually before
activity.

EMERGENCY TREATMENT OF PULMONARY OEDEMA: 0.8-2.4mg
sublingually every 5-10mins



Oral

ANGINA PROPHYLAXIS:
(SR tabs/caps) 2.5-6.5mg 8-12 hrly



Transdermal Oint

ANGINA PROPHYLAXIS:
(2% oint) 1-2 inch ribbon applied ot
the chest, abdomen or thigh wihtout rubbing-in, every 3-4 hrs as
reqd.



Transdermal Patch

ANGINA PROPHYLAXIS:
(5mg or 10mg/24hrs patches) 5mg or 10mg
patch applied to the lateral chest wall. Replace patch every
24hrs. Max: Two 10mg patches/day.

IV
Infusion

CONTROL OF BP IN PERIOPERATIVE HYPERTENSION, CHF ASSOCIATED WITH
AMI, UNSTABLE ANGINA:
Intially 5mcg/min every 3-5 mins. If
no response at 20mcg/min every min, further increments of
10-20mcg/min. Depending on response, later rate adusted Aerosol
spray.

TREATMENT OR PROPHYLAXIS OF ANGINA:
(400 micorgrams/metered dose); Spray 1-2 doses sublingually and
then close mouth. If necessary, more doses can be given but within
15 mins, not more than 3 doses.

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Action

Glyceryl trinitrate
relaxes smooth muscle especially in the blood vessels. Reduces
venous return (preload) and facilitates subendocardial blood flow
with redistribution into ischaemic areas. Relieves coronary
vasospasm. dilates arterioles and reduces afterload.Useful for
relief and prevention of anginal attacks.

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Interaction



The hypotensive effects
of glyceryl trinitrate may be enhanced by alcohol, and by
vasodilators and other drugs with hypotensive actions. The
effectiveness of sublingual and buccal tablet preparations may be
reduced by drugs that cause dry mouth since dissolution may be
delayed.

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Adverse
Effect & Precaution




Throbbing headache,
weakness, sweating, flushing, diziness, tachycardia, palpitation,
methaemoglobinaemia, fainting.



Precaution: Pulmonary disease, cerebrovascular disease.

Pregnancy: Use with Caution

Breast Feeding: Use with Caution

Man: Use with Caution



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Brands
available in market












































 


ANGISED

Burroughs
Wellcome
TAB 0.5mg 30 12.04
ANGISPAN-TR

USV
SR-CAPS 2.5mg 50 88.00
CAPS 2.5mg 50 88.00
SR-CAPS 6.5mg 50 115.00
CAPS 6.5mg 50 115.00
GTN
SPRAY

Medley
SPRAY 0.4mg
released per actuation
200mtd 120.00
MILLISROL

Khandelwal
INJ 5mg/10ml 10ml 34.46
MYOCARE

Criticare
INJ 25mg/ml 5ml 54.35
MYOINT

Troikaa
INJ 5mg/ml 5x5ml 225.00
VIAL 5mg/ml 5x10ml 350.00
MYOVIN

Cadila
Pharma
OINT 30g 2% 34.00
OINT 60g 2% 41.50
NIG

VHB
INJ 25mg/ml 5AMPS 225.00
INJ 50mg/ml 5AMPS 337.00
NITROCONTIN

Modi
Mundi Pharma
TAB 2.6mg 25 50.25
TAB 6.4mg 25 71.50
NITROCURE

Panacea
INJ 25mg/5ml 1x10AMP 54.00
NITRODERM
TTS

Novartis
PATCH 5mg 24hrs 41.50
PATCH 10mg 24hrs 52.50
NITROGLYCERINE
– CHILE

Shree
Ganesh
INJ 5mg/10ml VIAL 89.00
NITROJECT

Sun
Pharma
INJ 25mg/ml 5ml 49.50
VIAL 50mg/10ml 10ml 73.50
NITROMINT

VHB
TAB 2.6mg 60 100.00
AEROSOL

10g 425.00




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Drug Information
  


Glyceryl Trinitrate
 

 
Pharmacokinetics

Administered by sublingual route it is absorbed rapidly.

Top
      

Indication & Dosage 

Sublingual
PROPHYLAXIS OR RELIEF OF ANGINAL ATTACK:
0.5mg ever 3 min until pain subsides. Prevention: 0.5mg sublingually before activity.
EMERGENCY TREATMENT OF PULMONARY OEDEMA: 0.8-2.4mg sublingually every 5-10mins

Oral
ANGINA PROPHYLAXIS:
(SR tabs/caps) 2.5-6.5mg 8-12 hrly

Transdermal Oint
ANGINA PROPHYLAXIS:
(2% oint) 1-2 inch ribbon applied ot the chest, abdomen or thigh wihtout rubbing-in, every 3-4 hrs as reqd.

Transdermal Patch
ANGINA PROPHYLAXIS:
(5mg or 10mg/24hrs patches) 5mg or 10mg patch applied to the lateral chest wall. Replace patch every 24hrs. Max: Two 10mg patches/day.

IV Infusion
CONTROL OF BP IN PERIOPERATIVE HYPERTENSION, CHF ASSOCIATED WITH AMI, UNSTABLE ANGINA:
Intially 5mcg/min every 3-5 mins. If no response at 20mcg/min every min, further increments of 10-20mcg/min. Depending on response, later rate adusted Aerosol spray.
TREATMENT OR PROPHYLAXIS OF ANGINA: (400 micorgrams/metered dose); Spray 1-2 doses sublingually and then close mouth. If necessary, more doses can be given but within 15 mins, not more than 3 doses.

Top

Action

Glyceryl trinitrate relaxes smooth muscle especially in the blood vessels. Reduces venous return (preload) and facilitates subendocardial blood flow with redistribution into ischaemic areas. Relieves coronary vasospasm. dilates arterioles and reduces afterload.Useful for relief and prevention of anginal attacks.

Top 
    

Interaction

The hypotensive effects of glyceryl trinitrate may be enhanced by alcohol, and by vasodilators and other drugs with hypotensive actions. The effectiveness of sublingual and buccal tablet preparations may be reduced by drugs that cause dry mouth since dissolution may be delayed.

Top
  

Adverse Effect & Precaution

Throbbing headache, weakness, sweating, flushing, diziness, tachycardia, palpitation, methaemoglobinaemia, fainting.

Precaution: Pulmonary disease, cerebrovascular disease.
Pregnancy: Use with Caution
Breast Feeding: Use with Caution
Man: Use with Caution


Top
    

 

ANGISED

Burroughs Wellcome

TAB

0.5mg

30

12.04

ANGISPAN-TR

USV

SR-CAPS

2.5mg

50

88.00

CAPS

2.5mg

50

88.00

SR-CAPS

6.5mg

50

115.00

CAPS

6.5mg

50

115.00

GTN SPRAY

Medley

SPRAY

0.4mg released per actuation

200mtd

120.00

MILLISROL

Khandelwal

INJ

5mg/10ml

10ml

34.46

MYOCARE

Criticare

INJ

25mg/ml

5ml

54.35

MYOINT

Troikaa

INJ

5mg/ml

5x5ml

225.00

VIAL

5mg/ml

5x10ml

350.00

MYOVIN

Cadila Pharma

OINT

30g

2%

34.00

OINT

60g

2%

41.50

NIG

VHB

INJ

25mg/ml

5AMPS

225.00

INJ

50mg/ml

5AMPS

337.00

NITROCONTIN

Modi Mundi Pharma

TAB

2.6mg

25

50.25

TAB

6.4mg

25

71.50

NITROCURE

Panacea

INJ

25mg/5ml

1x10AMP

54.00

NITRODERM TTS

Novartis

PATCH

5mg

24hrs

41.50

PATCH

10mg

24hrs

52.50

NITROGLYCERINE – CHILE

Shree Ganesh

INJ

5mg/10ml

VIAL

89.00

NITROJECT

Sun Pharma

INJ

25mg/ml

5ml

49.50

VIAL

50mg/10ml

10ml

73.50

NITROMINT

VHB

TAB

2.6mg

60

100.00

AEROSOL

10g

425.00


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By |2022-07-20T16:41:38+00:00July 20, 2022|Uncategorized|Comments Off on Glyceryl Trinitrate

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