Drug Information

   





Griseofulvin



    











 

Pharmacokinetics

 



Griseofulvin is given orally in divided doses to attain maximum level in
the blood. It is mainly excreted through faeces.Because of its very low
water solublity absorption from G.I.T is irregular.Absorption is
increased by taking it with fat and by microfining the drug
particles.Griseofulvin gets deposited in keratin forming cells of skin,
hair and nails.It is specially concentrated and retained in tinea
infected cells.

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Indication
& Dosage





Oral

RINGWORM INFECTIONS OF SKIN, SCALP AND NAILS, TINEA CORPORIS,
T.PEDIS, T.CRURIS, T.BARBAE, T.CAPITIS AND T.UNGUIUM:
250-37mg/day as
single or in div doses. May be increased to 250mg t.i.d Children:
10mg/kg daily.

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Action

Fungistatic against common
dermatophytes such as Microsporum, Epidermophyton and trichophyton. It
is not effective against candida, histoplama, actinomycosis and
coccidioidomycosis

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Interaction

Griseofulvin
may decrease the effect of anticoagulants in some patients. While taking
Oral contraceptives containing estrogen with Griseofulvin, the effect of
contraception is decreased, which may result in breakthrough bleeding
and unwanted pregnancies.

Top
 
 

Adverse
Effect & Precaution




Nausea, epigastric distress,
vomiting, headache, peripheral neurtitis, skin rash, photosensitivity,
drowsiness and transient leucopenia.

Griseofulvin may increase the effects of alcohol. If
taken with alcohol it may also cause tachycardia, increased sweating,
flushing of the face.

Pregnancy: Contraindicated.

Breast Feeding: Use with Caution.

Man: May be used.

Top
 

   

Brands
available in market













































 



DERMONORM


Glaxo Allenburys


TAB


250mg


10


19.55


TAB


500mg


10


38.12


FLUVIN


Bombay Tablets


TAB


125mg


10


11.43


FORTE-TAB


250mg


8


18.41


TAB


500mg


10


41.56


FUNGIVIN


Euphoric


TAB


125mg


8


7.90


TAB


250mg


8


16.05


GEOVIN


Shalaks


TAB


125mg


10


10.85


TAB


250mg


10


20.25


GRIS O.D.


American Remedies


TAB


375mg


10


34.00


GRISACTIN FORTE


CFL


TAB


250mg


10


22.77


GRISOMED


Comed


TAB


250mg


20×10


303.60


TAB


375mg


10×10


357.00


GROSPRAL


Bal Pharma


TAB


250mg


10


16.02


GRISOVIN-FP


Glaxo


TAB


250mg


10


23.36


TAB


500mg


10


38.12


IDLFULVIN


IDPL


TAB


125mg


10


6.58


TAB


250mg


10


12.43


NUFULVIN


Nulife


TAB


125mg


10


8.93


TAB


250mg


10


15.09


ULVIN


Seagull


TAB


250mg


10


32.50


TAB


275mg


10


48.50


WALAVIN-250


Wallace


TAB


250mg


10


19.00


Top


 



 






 

       

    
Drug Information
   


Griseofulvin
    

 
Pharmacokinetics
 

Griseofulvin is given orally in divided doses to attain maximum level in the blood. It is mainly excreted through faeces.Because of its very low water solublity absorption from G.I.T is irregular.Absorption is increased by taking it with fat and by microfining the drug particles.Griseofulvin gets deposited in keratin forming cells of skin, hair and nails.It is specially concentrated and retained in tinea infected cells.

Top 
  

Indication & Dosage

Oral
RINGWORM INFECTIONS OF SKIN, SCALP AND NAILS, TINEA CORPORIS, T.PEDIS, T.CRURIS, T.BARBAE, T.CAPITIS AND T.UNGUIUM:
250-37mg/day as single or in div doses. May be increased to 250mg t.i.d Children: 10mg/kg daily.

Top  
   

Action

Fungistatic against common dermatophytes such as Microsporum, Epidermophyton and trichophyton. It is not effective against candida, histoplama, actinomycosis and coccidioidomycosis

Top  
  

Interaction

Griseofulvin may decrease the effect of anticoagulants in some patients. While taking Oral contraceptives containing estrogen with Griseofulvin, the effect of contraception is decreased, which may result in breakthrough bleeding and unwanted pregnancies.

Top   

Adverse Effect & Precaution

Nausea, epigastric distress, vomiting, headache, peripheral neurtitis, skin rash, photosensitivity, drowsiness and transient leucopenia.

Griseofulvin may increase the effects of alcohol. If taken with alcohol it may also cause tachycardia, increased sweating, flushing of the face.
Pregnancy: Contraindicated.
Breast Feeding: Use with Caution.
Man: May be used.

Top  
   

 

DERMONORM

Glaxo Allenburys

TAB

250mg

10

19.55

TAB

500mg

10

38.12

FLUVIN

Bombay Tablets

TAB

125mg

10

11.43

FORTE-TAB

250mg

8

18.41

TAB

500mg

10

41.56

FUNGIVIN

Euphoric

TAB

125mg

8

7.90

TAB

250mg

8

16.05

GEOVIN

Shalaks

TAB

125mg

10

10.85

TAB

250mg

10

20.25

GRIS O.D.

American Remedies

TAB

375mg

10

34.00

GRISACTIN FORTE

CFL

TAB

250mg

10

22.77

GRISOMED

Comed

TAB

250mg

20×10

303.60

TAB

375mg

10×10

357.00

GROSPRAL

Bal Pharma

TAB

250mg

10

16.02

GRISOVIN-FP

Glaxo

TAB

250mg

10

23.36

TAB

500mg

10

38.12

IDLFULVIN

IDPL

TAB

125mg

10

6.58

TAB

250mg

10

12.43

NUFULVIN

Nulife

TAB

125mg

10

8.93

TAB

250mg

10

15.09

ULVIN

Seagull

TAB

250mg

10

32.50

TAB

275mg

10

48.50

WALAVIN-250

Wallace

TAB

250mg

10

19.00

Top
 

 

 

By |2022-07-20T16:42:59+00:00July 20, 2022|Uncategorized|Comments Off on Griseofulvin

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