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Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interaction
Adverse
Effect & Precautions |
Brands available in Market
Pharmacokinetics
Griseofulvin is given orally in divided doses to attain maximum level in
the blood. It is mainly excreted through faeces.Because of its very low
water solublity absorption from G.I.T is irregular.Absorption is
increased by taking it with fat and by microfining the drug
particles.Griseofulvin gets deposited in keratin forming cells of skin,
hair and nails.It is specially concentrated and retained in tinea
infected cells.
Indication
& Dosage
Oral
RINGWORM INFECTIONS OF SKIN, SCALP AND NAILS, TINEA CORPORIS,
T.PEDIS, T.CRURIS, T.BARBAE, T.CAPITIS AND T.UNGUIUM: 250-37mg/day as
single or in div doses. May be increased to 250mg t.i.d Children:
10mg/kg daily.
Fungistatic against common dermatophytes such as Microsporum, Epidermophyton and trichophyton. It is not effective against candida, histoplama, actinomycosis and coccidioidomycosis
Griseofulvin may decrease the effect of anticoagulants in some patients. While taking Oral contraceptives containing estrogen with Griseofulvin, the effect of contraception is decreased, which may result in breakthrough bleeding and unwanted pregnancies.
Adverse
Effect & Precaution
Nausea, epigastric distress,
vomiting, headache, peripheral neurtitis, skin rash, photosensitivity,
drowsiness and transient leucopenia.
Griseofulvin may increase the effects of alcohol. If
taken with alcohol it may also cause tachycardia, increased sweating,
flushing of the face.
Pregnancy: Contraindicated.
Breast Feeding: Use with Caution.
Man: May be used.
