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Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interaction
Adverse
Effect & Precautions |
Brands available in Market
Pharmacokinetics
Ibuprofen
is phenylpropionic acid derivative. When given orally it is well
absorbed and is highly plasma protein bound. It gets metabolised in the
liver. It has a half-life of 2 hrs. About 10% gets excreted in the
urine.
Oral
MUSCULO-SKELETAL PAINS OF ALL TYPES INCLUDING TRAUMA, RA, OA AND
ANKYLOSING SPONDYLITIS, CHRONIC JUVENILE ARTHRITIS, ACUTE GOUT,
DYSMENORRHOEA AND OTHER PAINS: 1.2-2.4G/day in 3-4 divided doses. Chronic
juvenile arthritis: 30mg/kg/day in divided doses. Sust. Rel preparations
are usually give twice daily.
CHRONIC JUVENILE ARTHRITIS: 20-40mg/kg in div doses.
ANTIPYRETIC IN CHILDREN:(1-12yrs) 7-20MG/KG/DAY IN 3 divided doses.
Under 1yr: Not recommended
Anti-inflammatory, analgesic and antipyretic. Analgesic effect
is independent of anti-inflammatory activity and has both central and
peripheral effect. Temperature is reduced in febrile patients. Potent
inhibitor of cyclo-oxygenase and prostaglandin synthesis. Prevents
formation of thromboxane A2 by platetels. May delay onset of labour
Ibuprofen when used with Asprin gets displaced from its site . When used with lithium and Methotrexate, it increases their toxicity. Ibuprofen antagonises the effect of diuretics like Frusemide and Thiazide diuretics.
Adverse
Effect & Precautions
Nausea, vomiting,
epigastric discomfort, dizziness, headache, skin rash,
thrombocytopenia.
In conditions like Colitis, Crohn’s disease,
Diverticulitis,Gastric ulcer, Diabetes mellitus, Hemorrhoids,
Hepatitis, renal disease, Rectal irritation or bleeding, Systemic
lupus erythematosus,alcoholics and tobacco use: the chance of
adverse effects may be increased.Ibuprofen has been rated as the
safest NSAID by the spontaneous adverse drug reaction reporting
system in UK.
Pregnancy: Contraindicated.
Breast Feeding: May be given.
Man: May be used in reduced dose.
ALFAM-400
Albert-David
TAB
400mg
10
6.74
ARFEN
Centaur
SUSP
100mg/5ml
10
10.93
BREN
Kopran
TAB
200mg
10
3.41
TAB
400mg
10
5.96
TAB
600mg
10
8.61
BRUFEN
Knoll Pharma
TAB
200mg
10
3.80
TAB
400mg
10
6.74
TAB
600mg
10
9.78
EMBRU
Malladi Drugs
TAB
400mg
10
7.45
EMFLAM
Merck
TAB
200mg
10
3.79
TAB
400mg
10
6.74
TAB
600mg
10
9.78
FEBRILIX
Knoll Pharma
SYRUP
100mg/5ml
10
12.91
FENLONG
SOL
TAB
400mg
10
17.56
IBRUMAC
Macleods
TAB
400mg
10
9.13
SUSP
125mg.ml
10
14.95
IBUBID T.R
Natco
TR-CAPS
300mg
10
9.35
SR-CAPS
600mg
10
8.55
IBUCON-400/600
Concept
TAB
400mg
10
8.50
TAB
600mg
10
9.50
IBUGESIC
Cipla
TAB
200mg
10
3.39
TAB
400mg
10
5.93
TAB
600mg
10
8.58
SUSP
100mg/5ml
10
8.49
IBUGESIC SR
Cipla
CAPS
300mg
10
8.45
IBUGIN
Glaxo
TAB
200mg
10
3.73
TAB
400mg
10
6.63
IBURIN
Unisearch
TAB
400mg
10
6.69
TAB
600mg
10
9.70
IBUSPAN SR
Emcure
TAB
800mg
10
18.99
IBUSYNTH
Astra-IDL
TAB
200mg
10
3.39
IBUSYNTH FORTE
Astra-IDL
TAB
400mg
10
5.93
INFLAPEN CR
Glaxo Allenburys
CR-CAPS
300mg
10
8.78
MYOFEN
Nulife
TAB
200mg
10
3.37
TAB
400mg
10
5.89
NORSWEL
Cadila Healthcare
TAB
400mg
10
6.54
NUREN
Dabur
TAB
200mg
10
3.83
TAB
400mg
10
6.81
REDUCIN
Unique
TAB
400mg
10
7.19
TABALON
Hoechst Marion Roussel
TAB
400mg
10
6.74
TRICOFEN
Max
TAB
200mg
10
3.68
TAB
400mg
10
6.54
TAB
600mg
10
9.49
