Drug Information

   


   










 

Pharmacokinetics



It is well absorbed orally. It has high protein binding – 90 %.It is
extensively metabolized in liver. It is converted in the body to its
metabolite desmethyl-imipramine, which is active. About 3 % is excreted in
the urine in the form of imino-dibenzylderivatives.


Top

  

Indication
& Dosage

Oral

ALL TYPES OF DEPRESSION, MOOD DISTURBANCE, CHRONIC PAIN, ANXIETY STATE
WITH DEPRESSION, OBSESSIONAL STATES, BULIMAL, ANOREXIA NERVOSA, PHOBIAS:

Intially 25mg t.i.d. increasing slowly to 100mg t.i.d. as reqd.

NOCTURNAL ENURESIS: 7-11 yrs: 35-50mg. Over 11 yrs: 50-75mg, at bedtime,
upto 3 months duration.

Top

    



Action


 



Inhibits noradrenaline reuptake and to a lesser extent that of
serotonin. Relatively less sedative than amitryptiline, it reduces REM
sleep and increases stage 4 sleep. Has some anticholinergic action. Can
prolong PR interval and flatten or inverse T wave.

Top

  



Interactions

If the drug is administered together with MAOI,
it often produces severe reactions similar to atropine poisoning,
hyperpyrexia, convulsions and coma. Thyroid preparations may
enhance its effects. It can potentiate the action of drugs like
phenylephrine, adrenaline and noradrenaline.




Top

  



Adverse
Effect & Precautions




Anticholinergic
side effects are common. Dry mouth, tachycardia, palpitation,
impotence, constipation, difficulty in accomomodation, rarely
hyperpyrexia and paralytic ileus. Lethargy, headache, drowsiness,
tremors, ataxia, sweating, convulsion. Urticaria, skin rash,
pruritus, cholestatic jaundice, cardiac arrhythmias, orthostatic
hypotension, agranulocytosis, gynoaecomastia, Loss of weight or
pain.

It should be used carefully in patients with
glaucoma or enlarged prostrate. In pregnancy the drug crosses the
placental barrier and can affect the fetus.

Pregnancy: Use with caution.

Breast Feeding: Use with caution.

Man: May be given in reduced dose.

Top

  



Brands available in market :























 

 



ANTIDEP

 

 



Torrent



CAPS



25mg



10



5.90



CAPS



75mg



10



15.40



DEPRANIL

 

 



LA Pharma



TAB



25mg



10



5.40



TAB



75mg



10



15.00



DEPSOL

 

 



Intas



TAB



25mg



10



5.75



TAB



75mg



10



15.25



DEPSONIL

 

 



SPPL



TAB



25mg



10



6.03



DEPSONIL-PM



SPPL



CAPS



(Imipramine pamoate(equiv to 75mg imipramine hcl) 112.25mg)



10



17.09



IMPRAMINE



Sun Pharma



TAB



25mg



10



6.10



CAPS



75mg



6



16.40



IMPREL



Sigma



TAB



25mg



12×10



55.56


Top

  



 

 






 

  

   
Drug Information
   

   

 
Pharmacokinetics

It is well absorbed orally. It has high protein binding – 90 %.It is extensively metabolized in liver. It is converted in the body to its metabolite desmethyl-imipramine, which is active. About 3 % is excreted in the urine in the form of imino-dibenzylderivatives.

Top
  

Indication & Dosage

Oral
ALL TYPES OF DEPRESSION, MOOD DISTURBANCE, CHRONIC PAIN, ANXIETY STATE WITH DEPRESSION, OBSESSIONAL STATES, BULIMAL, ANOREXIA NERVOSA, PHOBIAS:
Intially 25mg t.i.d. increasing slowly to 100mg t.i.d. as reqd.
NOCTURNAL ENURESIS: 7-11 yrs: 35-50mg. Over 11 yrs: 50-75mg, at bedtime, upto 3 months duration.

Top
    

Action
 

Inhibits noradrenaline reuptake and to a lesser extent that of serotonin. Relatively less sedative than amitryptiline, it reduces REM sleep and increases stage 4 sleep. Has some anticholinergic action. Can prolong PR interval and flatten or inverse T wave.

Top
  

Interactions

If the drug is administered together with MAOI, it often produces severe reactions similar to atropine poisoning, hyperpyrexia, convulsions and coma. Thyroid preparations may enhance its effects. It can potentiate the action of drugs like phenylephrine, adrenaline and noradrenaline.

Top
  

Adverse Effect & Precautions

Anticholinergic side effects are common. Dry mouth, tachycardia, palpitation, impotence, constipation, difficulty in accomomodation, rarely hyperpyrexia and paralytic ileus. Lethargy, headache, drowsiness, tremors, ataxia, sweating, convulsion. Urticaria, skin rash, pruritus, cholestatic jaundice, cardiac arrhythmias, orthostatic hypotension, agranulocytosis, gynoaecomastia, Loss of weight or pain.

It should be used carefully in patients with glaucoma or enlarged prostrate. In pregnancy the drug crosses the placental barrier and can affect the fetus.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: May be given in reduced dose.

Top
  

Brands available in market :

 

 

ANTIDEP

 

 

Torrent

CAPS

25mg

10

5.90

CAPS

75mg

10

15.40

DEPRANIL

 

 

LA Pharma

TAB

25mg

10

5.40

TAB

75mg

10

15.00

DEPSOL

 

 

Intas

TAB

25mg

10

5.75

TAB

75mg

10

15.25

DEPSONIL

 

 

SPPL

TAB

25mg

10

6.03

DEPSONIL-PM

SPPL

CAPS

(Imipramine pamoate(equiv to 75mg imipramine hcl) 112.25mg)

10

17.09

IMPRAMINE

Sun Pharma

TAB

25mg

10

6.10

CAPS

75mg

6

16.40

IMPREL

Sigma

TAB

25mg

12×10

55.56

Top
  

 
 

 

By |2022-07-20T16:42:57+00:00July 20, 2022|Uncategorized|Comments Off on Imipramine

About the Author: