Drug Information

 


    










 

Pharmacokinetics

 

Indapamide is
rapidly and completely absorbed from the gastrointestinal tract.
Elimination is biphasic with a half-life in whole blood of about 14
hours. Indapamide is strongly bound to red blood cells. It is
extensively metabolised. About 60 to 70% of the dose has been reported
to be excreted in the urine; only about 5 to 7% is excreted unchanged.
About 16 to 23% of the administered dose is excreted in the faeces.
Indapamide is not removed by haemodialysis but does not accumulate in
patients with impaired renal function.

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Indication
& Dosage

Oral

MILD TO MODERATE

HYPERTENSION:
2.5mg once daily.

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Action


 



Exerts antihypertensive effects at doses lower than those for
diuretic action. Possible relaxation of vascular smooth muscle by
inhibition of net Ca2+ inflow.

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Interactions

Diazoxide:
Synergistic action- may cause hyperglycemia, hyperuricaemia and
hypotension.

Digitalis: Diuretic induced hypokalaemia may precipitate digitalis
toxicity.

Frusemide: Synergy leading to profound diuresis and greater than
predicted electrolyte loss.

Sulfonylureas: Hypoglycaemic effects enhanced.

Chlorpropamide: Hypokalaemia.

Porpantheline: Bioavailability of indapamide increased.

Metoclopramide: Bioavailability of indapamide decreased.

NSAID’s: Natriuretic effect of indapamide decreased


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Adverse
Effect & Precautions




Nausea, epigastric
distress, fatigue, weakness, hperuricaemia, hypokalaemic muscle
cramps. Reduction in glucose tolerance. Orthostatic hypotension.
Allergic manifestations.



Severe hepatic or renal impairment, children. Patients with
history of allergy to sulfonamides derivatives shoulb be closely
monitored.

Pregnancy: Use with caution.

Breast Feeding: Use with caution.

Man: Use with caution.

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Brands available in market :












LORVAS


Torrent


TAB


2.5mg


10


20.50


NATRILIX


Serdia


TAB


2.5mg


10


59.20


NATRILIX SR


Serdia


SR-TAB


1.5mg


10


69.00



  
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Drug Information
 

    

 
Pharmacokinetics
 
Indapamide is rapidly and completely absorbed from the gastrointestinal tract. Elimination is biphasic with a half-life in whole blood of about 14 hours. Indapamide is strongly bound to red blood cells. It is extensively metabolised. About 60 to 70% of the dose has been reported to be excreted in the urine; only about 5 to 7% is excreted unchanged. About 16 to 23% of the administered dose is excreted in the faeces. Indapamide is not removed by haemodialysis but does not accumulate in patients with impaired renal function.

Top
  

Indication & Dosage

Oral
MILD TO MODERATE
HYPERTENSION:
2.5mg once daily.

Top
  

Action
 

Exerts antihypertensive effects at doses lower than those for diuretic action. Possible relaxation of vascular smooth muscle by inhibition of net Ca2+ inflow.

Top
  

Interactions

Diazoxide: Synergistic action- may cause hyperglycemia, hyperuricaemia and hypotension.
Digitalis: Diuretic induced hypokalaemia may precipitate digitalis toxicity.
Frusemide: Synergy leading to profound diuresis and greater than predicted electrolyte loss.
Sulfonylureas: Hypoglycaemic effects enhanced.
Chlorpropamide: Hypokalaemia.
Porpantheline: Bioavailability of indapamide increased.
Metoclopramide: Bioavailability of indapamide decreased.
NSAID’s: Natriuretic effect of indapamide decreased

Top
   

Adverse Effect & Precautions

Nausea, epigastric distress, fatigue, weakness, hperuricaemia, hypokalaemic muscle cramps. Reduction in glucose tolerance. Orthostatic hypotension. Allergic manifestations.

Severe hepatic or renal impairment, children. Patients with history of allergy to sulfonamides derivatives shoulb be closely monitored.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: Use with caution.

Top
  

Brands available in market :

LORVAS

Torrent

TAB

2.5mg

10

20.50

NATRILIX

Serdia

TAB

2.5mg

10

59.20

NATRILIX SR

Serdia

SR-TAB

1.5mg

10

69.00

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By |2022-07-20T16:42:58+00:00July 20, 2022|Uncategorized|Comments Off on Indapamide

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