Drug Information

  





Indomethacin



 










 

Pharmacokinetics




It is readily absorbed from the GI tract, 99% bound to plasma protenins,
distributed into synovial fluid, the central nervous sytem, placenta and
breast milk. It is is metabolised in the liver to its glucuronide
conjugates, excretion of metabolites is predominantly in the urine with
some amount appearing in the faeces.


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Indication
& Dosage

Oral

RA, OSTEOARTHRITIS, ANKYLOSING SPONDYLITIS, ACUTE GOUT  ACUTE MUSCULO-SKELETAL
DISORDERS:
25mg 2 or 3 times daily. Oral Sust. Rel caps (75mg) in cap
o.d.

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Action


 


Anti-inflammatory, analgesic, antipyretic and antigout actions.
Potent inhibitor of cyclo-oxyenase, reducing prostaglandin synthesis.
Relieves pain and reduces temperature in febrile patients. Reduces pain
and joint swelling in rheumatoid arthritis (RA)  but does not modify
progress. Also used topically in the eye to reduce local inflammation.

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Interactions



Antigoagulants: May prolong prothrombin time. Instruct patients to
watch for signs & symptoms of bleeding. ACE inhibitors:
Antihypertensive effects of captopril may be blunted or completely
abolished by indomethacin. 

Beta-Blockers: Antihypertensive effect may be blunted.

Cyclosporine: Nephrotoxicity of both agents may be increased.

Digoxin: Serum digoxin levels may be increased by ibuprofen.


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Adverse
Effect & Precautions


 


Nausea, vomting, anorexia, gastric bleeding, diarrhoea, dizziness,
frontal headache, confusion, depression, psyache, confusion,
depression, psychosis, hallucination and leukopenia, epigastric
distress. Rarely aplastic anaemia.  Most adverse effects are
dose related.



Precaution: Impairment of hepatic function

Pregnancy: Contraindicated.

Breast Feeding: Contraindicated.

Man: Use with caution.

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Brands available in market :




























ARTISID


Sun Pharma


CAPS


25mg


5x2x10


95.00


CAPS


50mg


10×10


149.00


IDICIN


IDPL


CAPS


25mg


10


4.35


INDOCAP


Jagsonpal


CAPS


25mg


10


12.22


SR-CAPS


75mg


10


33.18


INDOFLAM


Recon


TR-CAPS


75mg


10


20.00


CAPS


25mg


10


7.96


INMECIN


Sterfillab


CAPS


25mg


10


5.93


CAPS


50mg


10


10.95


INMECIN-R


Sterfillab


CAPS


75mg


10


19.95


INOCIN


Bombay Tablets


CAPS


25mg


8


6.00


MICROCID


Micro Labs


TAB


25mg


10


9.80


SR-TAB


50mg


10


31.80









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Drug Information
  


Indomethacin
 

 
Pharmacokinetics


It is readily absorbed from the GI tract, 99% bound to plasma protenins, distributed into synovial fluid, the central nervous sytem, placenta and breast milk. It is is metabolised in the liver to its glucuronide conjugates, excretion of metabolites is predominantly in the urine with some amount appearing in the faeces.

Top
  

Indication & Dosage

Oral
RA, OSTEOARTHRITIS, ANKYLOSING SPONDYLITIS, ACUTE GOUT  ACUTE MUSCULO-SKELETAL DISORDERS:
25mg 2 or 3 times daily. Oral Sust. Rel caps (75mg) in cap o.d.

Top
  

Action
 

Anti-inflammatory, analgesic, antipyretic and antigout actions. Potent inhibitor of cyclo-oxyenase, reducing prostaglandin synthesis. Relieves pain and reduces temperature in febrile patients. Reduces pain and joint swelling in rheumatoid arthritis (RA)  but does not modify progress. Also used topically in the eye to reduce local inflammation.

Top
  

Interactions

Antigoagulants: May prolong prothrombin time. Instruct patients to watch for signs & symptoms of bleeding. ACE inhibitors: Antihypertensive effects of captopril may be blunted or completely abolished by indomethacin. 
Beta-Blockers: Antihypertensive effect may be blunted.
Cyclosporine: Nephrotoxicity of both agents may be increased.
Digoxin: Serum digoxin levels may be increased by ibuprofen.

Top
  

Adverse Effect & Precautions
 

Nausea, vomting, anorexia, gastric bleeding, diarrhoea, dizziness, frontal headache, confusion, depression, psyache, confusion, depression, psychosis, hallucination and leukopenia, epigastric distress. Rarely aplastic anaemia.  Most adverse effects are dose related.

Precaution: Impairment of hepatic function
Pregnancy: Contraindicated.
Breast Feeding: Contraindicated.
Man: Use with caution.

Top
  

Brands available in market :

ARTISID

Sun Pharma

CAPS

25mg

5x2x10

95.00

CAPS

50mg

10×10

149.00

IDICIN

IDPL

CAPS

25mg

10

4.35

INDOCAP

Jagsonpal

CAPS

25mg

10

12.22

SR-CAPS

75mg

10

33.18

INDOFLAM

Recon

TR-CAPS

75mg

10

20.00

CAPS

25mg

10

7.96

INMECIN

Sterfillab

CAPS

25mg

10

5.93

CAPS

50mg

10

10.95

INMECIN-R

Sterfillab

CAPS

75mg

10

19.95

INOCIN

Bombay Tablets

CAPS

25mg

8

6.00

MICROCID

Micro Labs

TAB

25mg

10

9.80

SR-TAB

50mg

10

31.80



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By |2022-07-20T16:41:39+00:00July 20, 2022|Uncategorized|Comments Off on Indomethacin

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