Drug Information

  


   



Isosorbide
dinitrate


        










 

Pharmacokinetics

When given orally it undergoes extensive first pass
metabolism hence it is administered sublingual.


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Indication
& Dosage



Sublingual

ACUTE ATTACKS OF ANGINA: 5-10mg




Oral

PREVENTION OF ATTACKS IN ALL TYPES OF ANGINA AND RELIEF OF CORONARY ARTERY
SPASM:
5-10mg q.i.d. Occasionally 20mg q.i.d may be needed. Sust. rel.
20-40mg b.i.d 

CONGESTIVE HEART FAILURE: 30-60mg q.i.d.




Aerosol Spray

TREATMENT AND PROPHYLAXIS OF ANGINA:
(1.25mg/metered dose) 1-3 sprays
under the tongue and close the mouth.


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Action


 


Like all organic nitrates, isosorbide dinitrate relaxes plain
muscle. It has no action on any other tissue. At lower doses this drug
dialtes venous capacitance vessels therby reducing venous return
(preload), conducting arteries and coronary collaterals.At higher doses
arterioles are dilated reducing afterload. In anginal patients, exercise
tolerance and time to one minute ST  depression are increased.
Anginal attacks and intesity are reduced.


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Interactions

 




Orthostatic
hypotension occurs when used together with: calcium channel
blockers, phenothiazines or tricyclic antidepressants.


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Adverse
Effect & Precautions


Headache is a common adverse effect. Dizziness
or lightheadedness may be more likely to occur in the elderly.
Anemia (severe) and Glaucoma: May be worsened by nitrates.In
Intracerebral hemorrhage (Recent): Nitrates may worsen the
condition. In recent Myocardial Infarction : Nitrates may cause
hypotension, which can aggravate problems associated with MI. In
renal disease and hepatic disease : Effects may be increased
because of slower removal of nitroglycerin from the body.



Preaction: Glaucoma, hypertension

Pregnancy: Use with caution.

Breast Feeding: Use with caution.

Man: use with caution.


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Brands available in market :

























CARDICAP


Natco


TAB


10mg


100


11.00


CAP


20mg


25


56.52


CAP


40mg


25


96.34


DINOSPRAY


Cipla


SPRAY


(1.25mg released/dose)


200md


160.00


DITRATE


Panacea


TAB


5mg


100


4.91


TAB


10mg


100


9.43


SR-TAB


20mg


10


19.33


SR-TAB


40mg


10


29.00


ISORDIL


Wyeth Lederle


TAB


10mg


100


19.66


ISORDIL SUBLINGUAL


Wyeth Lederle


TAB


5mg


100


11.79


SORBITRATE


Nicholas-Piramal


TAB


10mg


100


10.16


TAB


5mg


50


7.61



Top


  



 






 

      

     
Drug Information
  

   
Isosorbide dinitrate
        

 
Pharmacokinetics

When given orally it undergoes extensive first pass metabolism hence it is administered sublingual.

Top
  

Indication & Dosage

Sublingual
ACUTE ATTACKS OF ANGINA: 5-10mg

Oral
PREVENTION OF ATTACKS IN ALL TYPES OF ANGINA AND RELIEF OF CORONARY ARTERY SPASM:
5-10mg q.i.d. Occasionally 20mg q.i.d may be needed. Sust. rel. 20-40mg b.i.d 
CONGESTIVE HEART FAILURE: 30-60mg q.i.d.

Aerosol Spray
TREATMENT AND PROPHYLAXIS OF ANGINA:
(1.25mg/metered dose) 1-3 sprays under the tongue and close the mouth.

Top
  

Action
 

Like all organic nitrates, isosorbide dinitrate relaxes plain muscle. It has no action on any other tissue. At lower doses this drug dialtes venous capacitance vessels therby reducing venous return (preload), conducting arteries and coronary collaterals.At higher doses arterioles are dilated reducing afterload. In anginal patients, exercise tolerance and time to one minute ST  depression are increased. Anginal attacks and intesity are reduced.

Top
    

Interactions
 

Orthostatic hypotension occurs when used together with: calcium channel blockers, phenothiazines or tricyclic antidepressants.

Top
  

Adverse Effect & Precautions

Headache is a common adverse effect. Dizziness or lightheadedness may be more likely to occur in the elderly. Anemia (severe) and Glaucoma: May be worsened by nitrates.In Intracerebral hemorrhage (Recent): Nitrates may worsen the condition. In recent Myocardial Infarction : Nitrates may cause hypotension, which can aggravate problems associated with MI. In renal disease and hepatic disease : Effects may be increased because of slower removal of nitroglycerin from the body.

Preaction: Glaucoma, hypertension
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: use with caution.

Top
  

Brands available in market :

CARDICAP

Natco

TAB

10mg

100

11.00

CAP

20mg

25

56.52

CAP

40mg

25

96.34

DINOSPRAY

Cipla

SPRAY

(1.25mg released/dose)

200md

160.00

DITRATE

Panacea

TAB

5mg

100

4.91

TAB

10mg

100

9.43

SR-TAB

20mg

10

19.33

SR-TAB

40mg

10

29.00

ISORDIL

Wyeth Lederle

TAB

10mg

100

19.66

ISORDIL SUBLINGUAL

Wyeth Lederle

TAB

5mg

100

11.79

SORBITRATE

Nicholas-Piramal

TAB

10mg

100

10.16

TAB

5mg

50

7.61

Top
  

 

 

By |2022-07-20T16:42:58+00:00July 20, 2022|Uncategorized|Comments Off on Isosorbide dinitrate

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