Drug Information

   





Isosorbide
-5- mononitrate




    










 

Pharmacokinetics



After oral administration hepatic first pass metabolism is less than
Isosorbide dinitrate, hence, systemic bioavailability is more.


Top


   

Indication
& Dosage

Oral

PREVENTIVE MANAGEMENT OF ANGINA: Intially 20mg 2-3 times daily or 40mg
b.id, upto 120mg daily in div doses if reqd. Sust. Release tabs: (40/60mg)
1 tab in the morning, increased to 2 tabs if reqd.

Sust. Release tabs: (40/60) i tab in the morning, increased to 2 tabs if
reqd.

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Action


 


Isosorbide 5-mononitrate (IS5MN) is an active metabolite of isosorbide
dinitrate. It relaxes plain muscle by which action it causes dilatation of
the venous capacitance vessels, arterioles and coronary avessels. Preload
and afterload are reduced and coronary flow is redistributed to ischemic
regions. Anginal attacks are reduced and exercise tolerance increased.

Top


  



Interactions



Alcohol: Severe hypotension and cardiovasuclar collapse.

Aspirin: Increaes serum concentrations of nitrates and their
actions.

Antihypertensives, TCAs, Phenothiazine, Calcium channel blockers:
Marked symptomatic orthostatic hypotension.

Lab Test: May interfere with the Zlatkis-Zakcolour reaction
causeing a false report of decreased serum cholesterol

Top


   



Adverse
Effect & Precautions




Flushing, throbing headache, palpitation, dizziness, sweating,
skin rash.



Precaution: Withdraw the drug gradually. Start therapy with low
doses.

Pregnancy: Use with caution.

Breast Feeding: Use with caution.

Man: Use with caution
.

Top


    



Brands available in market :

















































































5 MONO


Biochem


TABS


10mg


10


9.96


TABS


20mg


10


18.11


TABS


40mg


10


34.41


ANGICOR


Novartis


TAB


10mg


10×10


192.50


SR-TAB


20mg


10×10


315.00


SR-TAB


40mg


10×10


350.00


ANGINEX


Wyeth Lederle


TAB


20mg


10


21.30


TAB


40mg


10


30.64


ANGITRIT


Unisearch


TAB


20mg


10


19.66


ANGIVAS CR 30


Yash


CR CAPS


50mg


10×10


315.20


ANGIVAS CR 50


Yash


CR CAPS


50mg


10×10


413.10


IHD


Stadmed


TAB


20mg


10


22.10


TAB


40mg


10


29.75


IMDUR


Astra-IDl


TAB


60mg


10


42.50


TAB


30mg


10


26.75


IMNIT


Dr.Reddy’s


SR-TAB


30mg


10


22.50


SR-TAB


60mg


10


35.10


ISOMO


Boehringer Mannheim


TAB


10mg


10


12.40


TAB


20mg


10


23.77


TAB


40mg


10


43.00


ISOCOR-20


Merck


TAB


20mg


10


17.09


ISOTEC


Sertec


TABS


10mg


10


11.00


TABS


20mg


10


20.50


ISOTRIM

Pace(SOL)


TAB


20mg


10


17.00


TAB


40mg


10


31.80


MONICOR


Wallace


TAB


20mg


10


16.05


MONIT 20


Intas


TAB


10mg


10


11.25


MONIT OD


Intas


SR-TAB


20mg


10


21.75


MONN


Natco


TAB


20mg


10


20.00


MONOCONTIN-25


Modi Mundi Pharma


TAB


25mg


10


24.50


MONOCONTIN-50


Modi Mundi Pharma


TAB


50mg


10


50.00


MONOMEN


Menarini raunaq


TAB


20mg


10


25.80


CR-TAB


50mg


10


46.44


MONOSROBITRATE


Nicholas-Piramal


TAB


20mg


10


23.46


TAB


40mg


10


36.72


MONOTRATE


Sun Pharma


TAB


10mg


10


11.85


TAB


20mg


10


21.72


TAB


40mg


10


39.27


MONOTRATE OD


Sun Pharma


TAB


50mg


10


41.24


NITROFIX


Carsyon(Microlabs)


TAB


20mg


10


15.00


TAB


10mg


10


8.00


TAB


40mg


10


25.00


VASONIT


Recon


TAB


10mg


10


8.62


TAB


20mg


10


14.65


TAB


40mg


10


24.55


VASOTRATE


Cipla


TAB


10mg


10


13.50


TAB


20mg


10


24.00


TAB


40mg


10


4.63







Top


  



 






 

     

  
 Drug Information
   


Isosorbide -5- mononitrate
    

 
Pharmacokinetics

After oral administration hepatic first pass metabolism is less than Isosorbide dinitrate, hence, systemic bioavailability is more.

Top
   

Indication & Dosage

Oral
PREVENTIVE MANAGEMENT OF ANGINA: Intially 20mg 2-3 times daily or 40mg b.id, upto 120mg daily in div doses if reqd. Sust. Release tabs: (40/60mg) 1 tab in the morning, increased to 2 tabs if reqd.
Sust. Release tabs: (40/60) i tab in the morning, increased to 2 tabs if reqd.

Top
  

Action
 

Isosorbide 5-mononitrate (IS5MN) is an active metabolite of isosorbide dinitrate. It relaxes plain muscle by which action it causes dilatation of the venous capacitance vessels, arterioles and coronary avessels. Preload and afterload are reduced and coronary flow is redistributed to ischemic regions. Anginal attacks are reduced and exercise tolerance increased.

Top
  

Interactions

Alcohol: Severe hypotension and cardiovasuclar collapse.
Aspirin: Increaes serum concentrations of nitrates and their actions.
Antihypertensives, TCAs, Phenothiazine, Calcium channel blockers: Marked symptomatic orthostatic hypotension.
Lab Test: May interfere with the Zlatkis-Zakcolour reaction causeing a false report of decreased serum cholesterol

Top
   

Adverse Effect & Precautions

Flushing, throbing headache, palpitation, dizziness, sweating, skin rash.

Precaution: Withdraw the drug gradually. Start therapy with low doses.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: Use with caution
.

Top
    

Brands available in market :

5 MONO

Biochem

TABS

10mg

10

9.96

TABS

20mg

10

18.11

TABS

40mg

10

34.41

ANGICOR

Novartis

TAB

10mg

10×10

192.50

SR-TAB

20mg

10×10

315.00

SR-TAB

40mg

10×10

350.00

ANGINEX

Wyeth Lederle

TAB

20mg

10

21.30

TAB

40mg

10

30.64

ANGITRIT

Unisearch

TAB

20mg

10

19.66

ANGIVAS CR 30

Yash

CR CAPS

50mg

10×10

315.20

ANGIVAS CR 50

Yash

CR CAPS

50mg

10×10

413.10

IHD

Stadmed

TAB

20mg

10

22.10

TAB

40mg

10

29.75

IMDUR

Astra-IDl

TAB

60mg

10

42.50

TAB

30mg

10

26.75

IMNIT

Dr.Reddy’s

SR-TAB

30mg

10

22.50

SR-TAB

60mg

10

35.10

ISOMO

Boehringer Mannheim

TAB

10mg

10

12.40

TAB

20mg

10

23.77

TAB

40mg

10

43.00

ISOCOR-20

Merck

TAB

20mg

10

17.09

ISOTEC

Sertec

TABS

10mg

10

11.00

TABS

20mg

10

20.50

ISOTRIM

Pace(SOL)

TAB

20mg

10

17.00

TAB

40mg

10

31.80

MONICOR

Wallace

TAB

20mg

10

16.05

MONIT 20

Intas

TAB

10mg

10

11.25

MONIT OD

Intas

SR-TAB

20mg

10

21.75

MONN

Natco

TAB

20mg

10

20.00

MONOCONTIN-25

Modi Mundi Pharma

TAB

25mg

10

24.50

MONOCONTIN-50

Modi Mundi Pharma

TAB

50mg

10

50.00

MONOMEN

Menarini raunaq

TAB

20mg

10

25.80

CR-TAB

50mg

10

46.44

MONOSROBITRATE

Nicholas-Piramal

TAB

20mg

10

23.46

TAB

40mg

10

36.72

MONOTRATE

Sun Pharma

TAB

10mg

10

11.85

TAB

20mg

10

21.72

TAB

40mg

10

39.27

MONOTRATE OD

Sun Pharma

TAB

50mg

10

41.24

NITROFIX

Carsyon(Microlabs)

TAB

20mg

10

15.00

TAB

10mg

10

8.00

TAB

40mg

10

25.00

VASONIT

Recon

TAB

10mg

10

8.62

TAB

20mg

10

14.65

TAB

40mg

10

24.55

VASOTRATE

Cipla

TAB

10mg

10

13.50

TAB

20mg

10

24.00

TAB

40mg

10

4.63


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By |2022-07-20T16:42:57+00:00July 20, 2022|Uncategorized|Comments Off on Isosorbide -5- mononitrate

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