Drug Information

    



      












Pharmacokinetics



It is given by parenteral  route.

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Indication
& Dosage





IM

RTI, OTITIS MEDIA, AND OTHER INFECTIONS BY SUSCEPTIBLE ORGANISMS IN
CNS, SOFT TISSUE, INFECTIONS: Adult and children:
15mg/kg/day in 2
equally divided doses. In more serious cases 15mg/kg/day can be divided
into 3 or 4 equal doses and given every 8-6 hours. In renal impairment,
the dosing interval may be prolonged according to the formula: dosage
interval in hours=Serum creatinine mg/100mlx9.

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Action

 

Bactericidal by inhibiting synthesis of bacterial proteins. Susceptible
organisms include Staph. aureus (including penicillinase-producing
strains), Staph. epidermidis N.gonorrhoeae, H.influenzae, E.coil,
Enterobacter, Shigella, Salmonella, Klebsiella pneumoniae, Serratia,
Providencia, and many strains of Proteus. Less active against
streptococci and enterococci.

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Interaction




Amphotericin B, Cisplatin, Cephalosporin, Vancomycin, Methoxyflurance,
Frusemide, Bumetanide: Increased nephrotoxicity. Anaesthetics,
Neuromuscular blocking agensts (Tubocurarine): Risk of neuromuscular
blockade and respiratory parlaysis.

Penicillin, Cephalosporins, Cafrbenicillin, Ticarcillin: Exer antibiotic
synergism, especially useful in Pseudomonas infections.

Loop diuretics: Concurrent use of these agents may increase the risk of
respiratory paralysis and renal dysfunction.

Lab Test: AMinoglycoside serum levels: Guard against invitro
inactivation of aminogly-cosides by B-Lactum antibiotics in patients on
combination therapy.

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Adverse
Effect &Precaution




Nephrotoxicity, ototoxicity,
neuromuscular blockade, headache, skin rash, utricaria, severe renal
failure



Precaution: Impaired renal function,
myasthenia gravis

Pregnancy: Contraindicated

Breast Feeding: Contraindicated

Man: Use with caution.

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Brands
available in market


 


















KANAMAC

Macleods

INJ

500mg

VIAL

15.25

INJ

750mg

VIAL

21.25

INJ

1g

VIAL

26.25

KANAMYCIN

Biochem

INJ

500mg

VIAL

14.21

INJ

1g

VIAL

26.05

KANCIN

Alembic

INJ

500mg

VIAL

17.10

INJ

1g

VIAL

30.20







Top

  


                                                      
                                               








 

       

   
Drug Information
    

      

Pharmacokinetics

It is given by parenteral  route.

Top
  

Indication & Dosage

IM
RTI, OTITIS MEDIA, AND OTHER INFECTIONS BY SUSCEPTIBLE ORGANISMS IN CNS, SOFT TISSUE, INFECTIONS: Adult and children:
15mg/kg/day in 2 equally divided doses. In more serious cases 15mg/kg/day can be divided into 3 or 4 equal doses and given every 8-6 hours. In renal impairment, the dosing interval may be prolonged according to the formula: dosage interval in hours=Serum creatinine mg/100mlx9.

Top
  

Action
 
Bactericidal by inhibiting synthesis of bacterial proteins. Susceptible organisms include Staph. aureus (including penicillinase-producing strains), Staph. epidermidis N.gonorrhoeae, H.influenzae, E.coil, Enterobacter, Shigella, Salmonella, Klebsiella pneumoniae, Serratia, Providencia, and many strains of Proteus. Less active against streptococci and enterococci.

Top
  

Interaction

Amphotericin B, Cisplatin, Cephalosporin, Vancomycin, Methoxyflurance, Frusemide, Bumetanide: Increased nephrotoxicity. Anaesthetics, Neuromuscular blocking agensts (Tubocurarine): Risk of neuromuscular blockade and respiratory parlaysis.
Penicillin, Cephalosporins, Cafrbenicillin, Ticarcillin: Exer antibiotic synergism, especially useful in Pseudomonas infections.
Loop diuretics: Concurrent use of these agents may increase the risk of respiratory paralysis and renal dysfunction.
Lab Test: AMinoglycoside serum levels: Guard against invitro inactivation of aminogly-cosides by B-Lactum antibiotics in patients on combination therapy.

Top
  

Adverse Effect &Precaution

Nephrotoxicity, ototoxicity, neuromuscular blockade, headache, skin rash, utricaria, severe renal failure

Precaution: Impaired renal function, myasthenia gravis
Pregnancy: Contraindicated
Breast Feeding: Contraindicated
Man: Use with caution.

Top
  

KANAMAC

Macleods

INJ

500mg

VIAL

15.25

INJ

750mg

VIAL

21.25

INJ

1g

VIAL

26.25

KANAMYCIN

Biochem

INJ

500mg

VIAL

14.21

INJ

1g

VIAL

26.05

KANCIN

Alembic

INJ

500mg

VIAL

17.10

INJ

1g

VIAL

30.20


Top
  

                                                                                                      

 

By |2022-07-20T16:42:55+00:00July 20, 2022|Uncategorized|Comments Off on Kanamycin

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