Drug Information

   


  











Pharmacokinetics


 



Ketoconazole is water soluble and is well absorbed from the GIT ;low
gastric pH enhances the absorption. It is highly protein bound in the
plasma. It gets metabolised in the liver.Distributed widely in all
tissues but CNS penetration is poor.Plasma half life is 8 hrs.

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Indication
& Dosage


 


Oral

SYSTEMIC INFECTIONS SUCH AS CANDIDIASIS, ORAL THRUSH, CHRONIC
MUCOCUTANEOUS CANDIDIASIS, BLASTOMYCOSIS COCCIDIOIDDOMYCOSIS,
HISTOPLASMOSIS. SEVERE PERSISTENT CUTANEOUS DERMATOPHYTE INFECTIONS:
200mg once or teice daily. Children over 2 yrs: 3.3-6.6 mg/kg as a
single daily dose. duration:1-2 weeks to upto 4 weeks. Minimum for 6
months for systemic mycosis.

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Action

 


A broad spectrum antifungal. Susceptible fungal pathogens include
dermatophytes, yeasts, dimorphic fungi, eumycetes, actinomycetes and
some phycomycetes. Both fungistatic (at low concentrations) and
fungicidal action(at high concentration).

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Interaction

 

Astemizole, Terfenadine. Methylphenidate, Nizatidine,
Omeprazole, Orphenadrine, Oxybutynin, Procainamide, Promethazine,
Quinidine, and Trimeprazine: may decrease the effects of Ketoconazole
these drugs should be taken at least 2 hours after Ketaconazole
therapy.Cisapride should not be taken with oral Ketaconazole, which may
increase the chance of serious adverse effects of Cisapride. Use of
Didanosine with ketaconazole may decrease the effects of both drugs.
Ketaconazole should be taken at least 2 hours before or 2 hours after
Didanosine is given.

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Precautions

   



Alcohol abuse may increase the
chance of adverse effects caused by azole antifungals.

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Brands
available in market

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Drug Information
   

  

Pharmacokinetics
 
Ketoconazole is water soluble and is well absorbed from the GIT ;low gastric pH enhances the absorption. It is highly protein bound in the plasma. It gets metabolised in the liver.Distributed widely in all tissues but CNS penetration is poor.Plasma half life is 8 hrs.

Top
   

Indication & Dosage
 
Oral
SYSTEMIC INFECTIONS SUCH AS CANDIDIASIS, ORAL THRUSH, CHRONIC MUCOCUTANEOUS CANDIDIASIS, BLASTOMYCOSIS COCCIDIOIDDOMYCOSIS, HISTOPLASMOSIS. SEVERE PERSISTENT CUTANEOUS DERMATOPHYTE INFECTIONS: 200mg once or teice daily. Children over 2 yrs: 3.3-6.6 mg/kg as a single daily dose. duration:1-2 weeks to upto 4 weeks. Minimum for 6 months for systemic mycosis.

Top
   

Action
 
A broad spectrum antifungal. Susceptible fungal pathogens include dermatophytes, yeasts, dimorphic fungi, eumycetes, actinomycetes and some phycomycetes. Both fungistatic (at low concentrations) and fungicidal action(at high concentration).

Top
   

Interaction
 
Astemizole, Terfenadine. Methylphenidate, Nizatidine, Omeprazole, Orphenadrine, Oxybutynin, Procainamide, Promethazine, Quinidine, and Trimeprazine: may decrease the effects of Ketoconazole these drugs should be taken at least 2 hours after Ketaconazole therapy.Cisapride should not be taken with oral Ketaconazole, which may increase the chance of serious adverse effects of Cisapride. Use of Didanosine with ketaconazole may decrease the effects of both drugs. Ketaconazole should be taken at least 2 hours before or 2 hours after Didanosine is given.

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Precautions
   
Alcohol abuse may increase the chance of adverse effects caused by azole antifungals.

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By |2022-07-20T16:41:38+00:00July 20, 2022|Uncategorized|Comments Off on Ketoconazole

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