Ketoconazole is water soluble and is well absorbed from the GIT ;low gastric pH enhances the absorption. It is highly protein bound in the plasma. It gets metabolised in the liver.Distributed widely in all tissues but CNS penetration is poor.Plasma half life is 8 hrs.
SYSTEMIC INFECTIONS SUCH AS CANDIDIASIS, ORAL THRUSH, CHRONIC MUCOCUTANEOUS CANDIDIASIS, BLASTOMYCOSIS COCCIDIOIDDOMYCOSIS, HISTOPLASMOSIS. SEVERE PERSISTENT CUTANEOUS DERMATOPHYTE INFECTIONS: 200mg once or teice daily. Children over 2 yrs: 3.3-6.6 mg/kg as a single daily dose. duration:1-2 weeks to upto 4 weeks. Minimum for 6 months for systemic mycosis.
A broad spectrum antifungal. Susceptible fungal pathogens include dermatophytes, yeasts, dimorphic fungi, eumycetes, actinomycetes and some phycomycetes. Both fungistatic (at low concentrations) and fungicidal action(at high concentration).
Astemizole, Terfenadine. Methylphenidate, Nizatidine, Omeprazole, Orphenadrine, Oxybutynin, Procainamide, Promethazine, Quinidine, and Trimeprazine: may decrease the effects of Ketoconazole these drugs should be taken at least 2 hours after Ketaconazole therapy.Cisapride should not be taken with oral Ketaconazole, which may increase the chance of serious adverse effects of Cisapride. Use of Didanosine with ketaconazole may decrease the effects of both drugs. Ketaconazole should be taken at least 2 hours before or 2 hours after Didanosine is given.
Alcohol abuse may increase the chance of adverse effects caused by azole antifungals.