Drug Information

   


      











Pharmacokinetics



It is given by parenteral route.

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Indication
& Dosage





IM/IV

ACUTE LYMPHOCYTIC LEUKAEMIA FOR INDUCTION OF REMISSION. NOT FOR
MAINTENANCE THERAPY: As a part of multidrug iduction regimens: IV: 1000 IU/kg/day
for 10 successive days as part of regimen with Prednisone, Vincristine
sulphate or IM: 6000 IU/m2 on Days 4,7,10,13,16,19,22,25,28 of the
treatment period with prednisone and vincristine sulpahte.

IV

SOLE AGENT FOR INDUCTION OF REMISSION:  Adults and children: 200 IU/KG
intravenously daily for 28 days. NOTE: When administered IV, drug should
be given over 30 mins along with normal saline/5% dextrose.

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Action

Rapidly depletes asparagine from malignant cells which depend on
exogenous sources for survival. Normal cells can synthesize asparagine and
are affected less. L-Asparaginase induces remission in some patients with
acute lymphocytic leukaemie.

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Interactions



Vincristine and Prednisone: Associated with increased toxicity.

Methotrexate: Effect on malignant cells diminished or abolished as
long as plasma asparginase levels are suppressed.

Cytarabine: Synegistic effect.

Lab Tests: Thyroid function tests: Interferes with its
interpretation.

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Adverse
Effect & Precautions




Nausea, vomiting, headache, fever, abdominal pain, hyperglycaemia
leading to coma, hypersensitivity, renal damge, coagulation
defects, trombosis, CNS depression or hyperexcitability, acute
haemorrhageic pancreatits.



Precaution: Hypersenstivity

Pregnancy: Use only if potential benefit justifies risk to the
foetus

Breast Feeding: Discontinue nursing or the drug.

Man: Use with caution.

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Brands available in market :










LEUCOGINASE


VHB


INJ


10000IU


VIAL


796.00


LEUNASE


Biochem


INJ


10000KU


VIAL


1095.00


TOP

   


                  







 

   

  
Drug Information
   

      

Pharmacokinetics

It is given by parenteral route.

TOP
    

Indication & Dosage

IM/IV
ACUTE LYMPHOCYTIC LEUKAEMIA FOR INDUCTION OF REMISSION. NOT FOR MAINTENANCE THERAPY: As a part of multidrug iduction regimens: IV: 1000 IU/kg/day for 10 successive days as part of regimen with Prednisone, Vincristine sulphate or IM: 6000 IU/m2 on Days 4,7,10,13,16,19,22,25,28 of the treatment period with prednisone and vincristine sulpahte.

IV
SOLE AGENT FOR INDUCTION OF REMISSION:  Adults and children: 200 IU/KG intravenously daily for 28 days. NOTE: When administered IV, drug should be given over 30 mins along with normal saline/5% dextrose.

TOP
   

Action

Rapidly depletes asparagine from malignant cells which depend on exogenous sources for survival. Normal cells can synthesize asparagine and are affected less. L-Asparaginase induces remission in some patients with acute lymphocytic leukaemie.

TOP
   

Interactions

Vincristine and Prednisone: Associated with increased toxicity.
Methotrexate: Effect on malignant cells diminished or abolished as long as plasma asparginase levels are suppressed.
Cytarabine: Synegistic effect.
Lab Tests: Thyroid function tests: Interferes with its interpretation.

TOP
   

Adverse Effect & Precautions

Nausea, vomiting, headache, fever, abdominal pain, hyperglycaemia leading to coma, hypersensitivity, renal damge, coagulation defects, trombosis, CNS depression or hyperexcitability, acute haemorrhageic pancreatits.

Precaution: Hypersenstivity
Pregnancy: Use only if potential benefit justifies risk to the foetus
Breast Feeding: Discontinue nursing or the drug.
Man: Use with caution.

TOP
   

 
Brands available in market :

LEUCOGINASE

VHB

INJ

10000IU

VIAL

796.00

LEUNASE

Biochem

INJ

10000KU

VIAL

1095.00

TOP
   

                  

 

By |2022-07-20T16:43:03+00:00July 20, 2022|Uncategorized|Comments Off on L-Asparaginase

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