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Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interactions
Adverse
Effect & Precautions |
Brands available in Market
Pharmacokinetics
Lamotrigine is almost completely absorbed after oral administration.
Lamotrigine is extensively metabolized. The mean plasma half life after
single dose of lamotrigine is approximately 24 hours.
Indication
& Dosage
Oral
AS ADJUCTIVE THERAPY IN SIMPLE PARTIAL SEIZURES AND SECODARILY GENERALISED
TONIC-CLONIC SEIZURES: With enzyme-inducing antiepileptic drugs (EIAEDs);
50mg o.d for weeks 1 and 2, followed by a 100mg/day in 2 div doses for
weeks 3 and 4. Maint; gradually increase by 100mg/day every 1-2 weeks to
achieve 200-400mg/day i 2 div doses. with valproic acid(VPA) alone or in
combination wiht other EIAEDs; 25mg every altenate day for weeks 1 & 2
followed by 25mg o.d. In weeks 3 & 4. 25-50mg/day in 2 div doses.
Renal functional impairment; Reduce the dose. Dosage titration should be
slow while initiating the therapy, and similarly, a step-wise dose
reduction should be followed at the time of discontinuation to prevent
rebound seizures.
Lamotrigine has demonstrated its usefulness as an add-on therapy in patients with partial epilepsy and those with secondarily generalized tonic-clonic seizures. As the precise mechanism of action is not established in humans, when in vitro pharmacological studies are concentrated, it has suggested that lamotrigine inhibits voltage-sensitive sodium channels, thereby stabilizingneuronal membranes and consequently modulating presynaptic transmitter release of excitatroy amino acids (eg., glutamate & aspartate).
Interactions
Phenytoin, carbamazepine, phenobarbitone and primidone: Enhance
the metabolism of lamotrigine and may increase dose require ments.
Sodium valproate: Reduces the metabolism of lamotrigine. There is
no evedence that lamotrigine causes clinically significant
induction or inhibition of hepatic oxidative drug-metabolizing
enzymes.
Adverse
Effect & Precautions
Headache, asthenia, rash, nausea, dizziness, somnolence and
insomnia.
Precaution: Severe skin rash including Stevens-Johnson syndrome
and rarely toxic Epidermal Necrolysis has been reported in some
cases. the incidence of such reaction is higher in paediatric
population. Lamotrigine should be discontinued at the first sign
of rashes. the risk is more in cases where (1) dose administered
exceeds the recommended initial and total dialy dose (2) sodium
valproate is co-administered.
Pregnancy: Use only if benefits outweigh.
Breast Feeding: Use with caution.
LAMETEC
Protec
TABS
25mg
10
30.00
LAMITOR
Torrent
TABS
25mg
10
26.11
