Drug Information

 


      











Pharmacokinetics




It a prodrug and is activated to sulphonamide dervatives. After
absorption the drug is extensively metabolsed in liver.

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Indication
& Dosage




Oral

BENIGN GASTRIC ULCER, DUODENAL ULCER, FREFLUX OESOPHAGITS: 30mg once daily
inthe morning for 4-8 weeks. In refractory cases daily dose may be
increased to 60mg fo 8-12 weeks.

ZOLLINGER-ELLISON SYNDROME: 60mg daily.

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Action

Inhibits the utimate step in gastric acid secretion,
the H+k+ATPase also known as the proton pump. Even stinulus- independent
acid secretion is suppressed. Both  basal and stinulated acid is
inhibited. Peptic acitivityis reduced secondary to acid inhibition.
Lansoprazole has a greater inhibitory effect on Helicobacter Pylori than
omeprazole.

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Interactions



Antacids: Bioaviability
of lansoprazole reduced Oral contraceptives, Phenytoin,
Theophylline and Waferin: Caution should be be exercised while
using these drug which are metabolised by the liver since
lansoprazole is a weak inducer of P 450 cytochrome.

TOP

    





Adverse
Effect & Precautions




Nausea, vomiting,
constipation, epigastric distress, dyspesia, skin rash, urticaria,
pruritis arthralgia, depression and peripheral oedema.



Precaution: Hepatic failure and possibility of gastric malignancy
to be excluded.

Pregnancy: Use with caution

Breast Feeding: Use with caution.

Man: Use with caution.

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Brands available in market :









































LAN-15


Intas


CAPS


15mg


10


25.25


LAN-30


Intas


CAPS


30mg


10


45.00


LANS OD


Recon


CAPS


30mg


10


39.50


LANS-MD


Recon


CAPS


15mg


10


25.00


LANSOFAST


Cadila Healthcare


CAPS


30mg


10


49.32


CAPS


15mg


10


31.70


LANSPEP


Khandelwal


CAPS


30mg


10


40.00


LANSPRO


Ind-Chemie


CAPS


30mg


10


45.00


LANZAP


Dr. Reddy’s


CAPS


30mg


10


44.10


CAPS


15mg


10


35.00


LANZO


Indon


CAPS


30mg


10


57.50


LANZOL


Cipla


CAPS


30mg


10


45.30


LANZOPEN


Morepen


CAPS


30mg


10


39.00


CAPS


15mg


10


24.00


LEVANT


Ranbaxy


CAPS


30mg


10


45.00


LEZO


Le Sante


CAPS


30mg


10


42.50


PROPILAN


Glemark


CAPS


30mg


10


44.50


CAPS


15mg


10


24.00


SPLANZ


Natco


CAPS


30mg


10


39.50


TOP

    



  







 

   


Drug Information
 

      

Pharmacokinetics

It a prodrug and is activated to sulphonamide dervatives. After absorption the drug is extensively metabolsed in liver.

TOP
      

Indication & Dosage

Oral
BENIGN GASTRIC ULCER, DUODENAL ULCER, FREFLUX OESOPHAGITS: 30mg once daily inthe morning for 4-8 weeks. In refractory cases daily dose may be increased to 60mg fo 8-12 weeks.
ZOLLINGER-ELLISON SYNDROME: 60mg daily.

TOP
    

Action

Inhibits the utimate step in gastric acid secretion, the H+k+ATPase also known as the proton pump. Even stinulus- independent acid secretion is suppressed. Both  basal and stinulated acid is inhibited. Peptic acitivityis reduced secondary to acid inhibition. Lansoprazole has a greater inhibitory effect on Helicobacter Pylori than omeprazole.

TOP
    

Interactions

Antacids: Bioaviability of lansoprazole reduced Oral contraceptives, Phenytoin, Theophylline and Waferin: Caution should be be exercised while using these drug which are metabolised by the liver since lansoprazole is a weak inducer of P 450 cytochrome.

TOP
    

Adverse Effect & Precautions

Nausea, vomiting, constipation, epigastric distress, dyspesia, skin rash, urticaria, pruritis arthralgia, depression and peripheral oedema.

Precaution: Hepatic failure and possibility of gastric malignancy to be excluded.
Pregnancy: Use with caution
Breast Feeding: Use with caution.
Man: Use with caution.

TOP
    

 
Brands available in market :

LAN-15

Intas

CAPS

15mg

10

25.25

LAN-30

Intas

CAPS

30mg

10

45.00

LANS OD

Recon

CAPS

30mg

10

39.50

LANS-MD

Recon

CAPS

15mg

10

25.00

LANSOFAST

Cadila Healthcare

CAPS

30mg

10

49.32

CAPS

15mg

10

31.70

LANSPEP

Khandelwal

CAPS

30mg

10

40.00

LANSPRO

Ind-Chemie

CAPS

30mg

10

45.00

LANZAP

Dr. Reddy’s

CAPS

30mg

10

44.10

CAPS

15mg

10

35.00

LANZO

Indon

CAPS

30mg

10

57.50

LANZOL

Cipla

CAPS

30mg

10

45.30

LANZOPEN

Morepen

CAPS

30mg

10

39.00

CAPS

15mg

10

24.00

LEVANT

Ranbaxy

CAPS

30mg

10

45.00

LEZO

Le Sante

CAPS

30mg

10

42.50

PROPILAN

Glemark

CAPS

30mg

10

44.50

CAPS

15mg

10

24.00

SPLANZ

Natco

CAPS

30mg

10

39.50

TOP
    

  

 

By |2022-07-20T16:42:57+00:00July 20, 2022|Uncategorized|Comments Off on Lansoprazole

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