Drug Information

   


   











Pharmacokinetics




Well absorbed by oral or
intramuscular administration and is rapidly converted to bilogically
active folated distribution occurs to all body tissues and is
concentrated in the  CSF. It is excreted in the urine.

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Indication
& Dosage




IM/IV

ANTIDOTE FOR METHOTREXATE TOCITIY: Amount equal to methotrexate dosage
administered as early as possible.

ADJUNCT THERAPY WIT 5 FU IN COLORECTAL CANCER:
200mg/mg by slow IV 
injection over 3 mins followed by 5 FU 370mg/m2 IV. Daily for 5 days.

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Action

Enter body folate pool as 5-methyltetrahydro folate.
Cna neutralise the effects of folic acid antagonists such as methotrexate
but increases those of 5-FU.

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Interactions



Methotrexate:
Methotrexate toxicity reduced. 

Fluorouracil: Cytotoxic effects of fluorouracil enhanced

Folic acid antagonist: Should not be coadministered with a folic
acid antagonist.

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Adverse
Effect & Precautions




Rarely
pyrexia.



Precaution: Should not be administered with folic acid antagonists

Pregnancy: Safety not established.

Breast Feeding: Safety not established.

Man: Use with caution.

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Brands available in market :
























CALICIUM LEUCOVORIN


Cynamid


INJ


3mg/ml


1 amps


14.80


FFERBON-KOREA


Shree Ganesh


INJ


3.2mg/ml


1ml amps


27.00


INJ


16mg/ml


1ml amps


100.00


INJ


3mg/ml


1amp


27.00


INJ


15mg/ml


1amp


100.00


LEUCOVORIN


Dabur


INJ


15mg/ml


1


100.50


INJ


3mg/ml


1


20.50


INJ


50mg/5ml


1


250.00


LEUCOVORIN CALCIUM


Biochem


INJ


3mg/ml


10 amps


240.00


NYRIN


VHB


INJ


3mg/ml


10amps


325.00


INJ


15mg/ml


10amps


1200.00


INJ


50mg/ml


10amps


2900.00


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Drug Information
   

   

Pharmacokinetics

Well absorbed by oral or intramuscular administration and is rapidly converted to bilogically active folated distribution occurs to all body tissues and is concentrated in the  CSF. It is excreted in the urine.

TOP
      

Indication & Dosage

IM/IV
ANTIDOTE FOR METHOTREXATE TOCITIY: Amount equal to methotrexate dosage administered as early as possible.
ADJUNCT THERAPY WIT 5 FU IN COLORECTAL CANCER:
200mg/mg by slow IV  injection over 3 mins followed by 5 FU 370mg/m2 IV. Daily for 5 days.

TOP
      

Action

Enter body folate pool as 5-methyltetrahydro folate. Cna neutralise the effects of folic acid antagonists such as methotrexate but increases those of 5-FU.

TOP
      

Interactions

Methotrexate: Methotrexate toxicity reduced. 
Fluorouracil: Cytotoxic effects of fluorouracil enhanced
Folic acid antagonist: Should not be coadministered with a folic acid antagonist.

TOP
      

Adverse Effect & Precautions

Rarely pyrexia.

Precaution: Should not be administered with folic acid antagonists
Pregnancy: Safety not established.
Breast Feeding: Safety not established.
Man: Use with caution.

TOP
      

Brands available in market :

CALICIUM LEUCOVORIN

Cynamid

INJ

3mg/ml

1 amps

14.80

FFERBON-KOREA

Shree Ganesh

INJ

3.2mg/ml

1ml amps

27.00

INJ

16mg/ml

1ml amps

100.00

INJ

3mg/ml

1amp

27.00

INJ

15mg/ml

1amp

100.00

LEUCOVORIN

Dabur

INJ

15mg/ml

1

100.50

INJ

3mg/ml

1

20.50

INJ

50mg/5ml

1

250.00

LEUCOVORIN CALCIUM

Biochem

INJ

3mg/ml

10 amps

240.00

NYRIN

VHB

INJ

3mg/ml

10amps

325.00

INJ

15mg/ml

10amps

1200.00

INJ

50mg/ml

10amps

2900.00

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