Drug Information

 


     











Pharmacokinetics

Lincomycin is given orally and intramuscularly. The
drug is well distributed throughout the body and is mainly concentrated
in the liver, spleen, kidney and lungs.Plasma half life is 5 hrs.

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Indication
& Dosage

IM/IV

INFECTIONS WIHT SUSCEPTIBLE ORGANISMS WHICH ARE RESISTANT TO OHTER
ANTIBIOTICS. IN PATIENTS WHO ARE ALLERGIC TO PENICILLINS. TONSILLITIS,
PHARYNGITIS, OTITIS MEDIA, SINUSITIS, ACUTE AND CHRONIC BRONCHITIS,
PNEUMONIA, SKIN AND SOFT TISSUE AND BONE & JOINT INFECTIONS,
OSTEOMYELITIS, SEPTIC ARTHRITIS, SEPTICAEMIA, ENDOCARDITIS:
600mg IM once
or twice daily or IV infusion 8-12 hrly of 600mg-1g. Higher doses upto 8g
have been given in life-threatening infections. For IV infusion lincomycin
1g is diltuted in 100ml of a parenteral solution and given at the rate of
100ml/hour Chidlren: 10mg/kg IM once or twice daily or 10-20mg/kg/day as
IV infusion in divided doses  every 8 or 12 hours.




Oral

INFECTION WITH SUSCEPTIBLE ORAGANISMS WHICH ARE RESISTANT TO OHTER
ANTIBIOTICS. IN PATIENTS WHO ARE ALLERGIC TO PENICILLINS. TONSILLITIS,
PHARYNGITIS, OTITIS MEDIA, SINUSTIS, ACUTE AND CHRONIC BRONCHITIS,
PNEUMONIA, SKIN AND SOFT TISSUE AND BONE & JOINT INFECTIONS:
500mg 3-4
times daily. Children: 30mg/kg/day in 3-4 equally divided doses. IN severe
infections upto 60mg/kg/day may be given. Renal impairment: In patients
with severe renal damage lincomycin doses should be reduced to 25-30 %.

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Action

Effective against most Gram-postive organisms.
Bacteriostatic or bactericidal depending on sensitivity and concentration.
Susceptible organisms unclude Staph. aureus, Staph. albus, beta-haemolytic
Streptococcus, Strep. viridans, Diplococcus pneumoniae, Clostridium tetani,
C.perfringens, Corynebacterium diphtheriae and C. acnes. Not active
against Strep. faecalis, Neisseriae, Haemophilus or other Gram-negative
pahtogens

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Interactions

Taking Chloramphenicol, Antidiarrhoeals may
decrease the effects of lincomycin.Erythromycin along with
lincomycin has synergistic effect .Antidiarrhoeals such as
loperamide when taken with Lincomycin may worsen diarrhoea which
is an adverse effect of lincomycin.

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Adverse
Effect & Precautions


 



Pain
at injection site, stomatitis, glossitis, angioneurotic oedema,
serum sickness, vertigo, tinnitus, aplastic anaemia. Hypotension
and cardiac arrest after rapid i.v. use. Anorexia, Metallic taste,
oesophagitis, abdominal pain.


Severe Renal and Hepatic disease may increase
serum levels of this drug, increasing the chance of adverse
effects. Patients with Gastric and intestinal disease like colitis
( including colitis caused by antibiotics, or enteritis) may have
an increased risk of adverse effects.

Pregnancy: Safety not established.

Breast Feeding: Best ot discontinue breast  feeding.

Man: Use with caution.

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Brands available in market :
















LINCOCIN


Max


CAPS


500mg


6


86.40


INJ


300mg/ml


2ml


34.00


LYNX


Wallace


CAPS


500mg


10


94.04


SYRUP


125mg/ml


60ml


45.00


INJ


300mg/ml


2ml


17.33


INJ


300mg/ml


1ml


9.58


INJ


300mg/ml


2ml/vial


20.00


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Drug Information
 

     

Pharmacokinetics

Lincomycin is given orally and intramuscularly. The drug is well distributed throughout the body and is mainly concentrated in the liver, spleen, kidney and lungs.Plasma half life is 5 hrs.

TOP
  

Indication & Dosage

IM/IV
INFECTIONS WIHT SUSCEPTIBLE ORGANISMS WHICH ARE RESISTANT TO OHTER ANTIBIOTICS. IN PATIENTS WHO ARE ALLERGIC TO PENICILLINS. TONSILLITIS, PHARYNGITIS, OTITIS MEDIA, SINUSITIS, ACUTE AND CHRONIC BRONCHITIS, PNEUMONIA, SKIN AND SOFT TISSUE AND BONE & JOINT INFECTIONS, OSTEOMYELITIS, SEPTIC ARTHRITIS, SEPTICAEMIA, ENDOCARDITIS:
600mg IM once or twice daily or IV infusion 8-12 hrly of 600mg-1g. Higher doses upto 8g have been given in life-threatening infections. For IV infusion lincomycin 1g is diltuted in 100ml of a parenteral solution and given at the rate of 100ml/hour Chidlren: 10mg/kg IM once or twice daily or 10-20mg/kg/day as IV infusion in divided doses  every 8 or 12 hours.

Oral
INFECTION WITH SUSCEPTIBLE ORAGANISMS WHICH ARE RESISTANT TO OHTER ANTIBIOTICS. IN PATIENTS WHO ARE ALLERGIC TO PENICILLINS. TONSILLITIS, PHARYNGITIS, OTITIS MEDIA, SINUSTIS, ACUTE AND CHRONIC BRONCHITIS, PNEUMONIA, SKIN AND SOFT TISSUE AND BONE & JOINT INFECTIONS:
500mg 3-4 times daily. Children: 30mg/kg/day in 3-4 equally divided doses. IN severe infections upto 60mg/kg/day may be given. Renal impairment: In patients with severe renal damage lincomycin doses should be reduced to 25-30 %.

TOP
  

Action

Effective against most Gram-postive organisms. Bacteriostatic or bactericidal depending on sensitivity and concentration. Susceptible organisms unclude Staph. aureus, Staph. albus, beta-haemolytic Streptococcus, Strep. viridans, Diplococcus pneumoniae, Clostridium tetani, C.perfringens, Corynebacterium diphtheriae and C. acnes. Not active against Strep. faecalis, Neisseriae, Haemophilus or other Gram-negative pahtogens

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Interactions

Taking Chloramphenicol, Antidiarrhoeals may decrease the effects of lincomycin.Erythromycin along with lincomycin has synergistic effect .Antidiarrhoeals such as loperamide when taken with Lincomycin may worsen diarrhoea which is an adverse effect of lincomycin.

TOP
  

Adverse Effect & Precautions
 
Pain at injection site, stomatitis, glossitis, angioneurotic oedema, serum sickness, vertigo, tinnitus, aplastic anaemia. Hypotension and cardiac arrest after rapid i.v. use. Anorexia, Metallic taste, oesophagitis, abdominal pain.

Severe Renal and Hepatic disease may increase serum levels of this drug, increasing the chance of adverse effects. Patients with Gastric and intestinal disease like colitis ( including colitis caused by antibiotics, or enteritis) may have an increased risk of adverse effects.
Pregnancy: Safety not established.
Breast Feeding: Best ot discontinue breast  feeding.
Man: Use with caution.

TOP
  

Brands available in market :

LINCOCIN

Max

CAPS

500mg

6

86.40

INJ

300mg/ml

2ml

34.00

LYNX

Wallace

CAPS

500mg

10

94.04

SYRUP

125mg/ml

60ml

45.00

INJ

300mg/ml

2ml

17.33

INJ

300mg/ml

1ml

9.58

INJ

300mg/ml

2ml/vial

20.00

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By |2022-07-20T16:41:40+00:00July 20, 2022|Uncategorized|Comments Off on Lincomycin

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