Drug Information

  


     











Pharmacokinetics

Lisinopril is slowly absorbed after oral
administration. It has 1/2 life of 7 hrs. It is excreted via the urine.

TOP

   

Indication
& Dosage



Oral

ESSENTIAL AND RENAL HYPERTENSION, CONGESTIVE HEART FAILURE;
Start with
2.5mg once daily. Increase gradually according to response. Max: 40mg/day.
Elderly: Very gradual dose increases with caution.

TOP

   



Action

Competetive inhibition of ACE. Reduction in levels of
angiotensin II (ATII) and aldosterone. Peripheral vasodilatation and
reduced peripheral resistance. Blood pressure reduction enhanced by salt
and water depletion e.g excessive sweating. In patients with congestive
failure, there is reduction in afterload and in pulmonary capillary wedge
pressure. Cardiac efficiency is increased as is also renal blood flow.

TOP

   




Interactions 

Lithium and Indomethacin reduce hypotensive
effect. Hydrochlorthiazide potentiates its effect.
Co-administration of cyclo-oxygenase causes reduction in renal
function.

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Adverse
Effect & Precautions


 



Diziness,
cough, hyperkalaemia, headache, hypotension, angio oedema.


Allergies: Allergic reaction to Lisinopril may
occur. Pregnancy: Studies in rats at doses many times the
recommended human dose have shown that use of lisinopril causes a
decrease in successful pregnancies, a decrease in the weight of
infants, and an increase in infant deaths. It has also caused
abnormal bone growth in rabbits.

Pregnancy: Contraindicated.

Breast Feeding: Use with caution

Man: May be used in reduced dose.

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Brands available in market :
























































































ACEBITOR


Croydon


TAB


5mg


10


35.60


TAB


10mg


10


61.26


ACETITOR


Croydon


TAB


10mg


10


61.26


ACINNOPRIL


Boehringer Mannheim


TAB


2.5mg


10


15.00


TAB


5mg


10


31.00


TAB


10mg


10


56.00


BIOPRIL


Biochem


TAB


2.5mg


10


17.10


TAB


5mg


10


32.20


TAB


10mg


10


59.36


CIPRIL


Cipla


TAB


2.5mg


10


19.35


TAB


5mg


10


35.25


TAB


10mg


10


68.35


DILACE


Orchid


TAB


5mg


10


30.00


HIPRIL


Micro Labs


TAB


2.5mg


10


17.50


TAB


5mg


10


34.80


ILIS


Recon


TAB


2.5mg


10


25.20


TAB


5mg


10


44.80


TAB


10mg


10


84.00


INRAS


Merind


TAB


2.5mg


10


20.85


TAB


5mg


10


36.50


TAB


10mg


10


76.80


LESOPRIL


Themis


TAB


5mg


10


62.50


LINVAS


Cadila Pharma


TAB


2.5mg


10


10.00


TAB


5mg


10


37.90


TAB


10mg


10


73.70


LIPRIL


Lupin


TAB


2.5mg


10


19.00


TAB


5mg


10


33.00


TAB


10mg


10


61.50


LISICARD


Gufic


TAB


2.5mg


10


19.06


TAB


5mg


10


36.05


TAB


10mg


10


70.04


LISINACE


Alkem


TAB


2.5mg


10


18.60


TAB


5mg


10


33.00


TAB


10mg


10


61.50


LISIR-5/10


Kramer


TAB


5mg


10


25.00


TAB


10mg


10


50.78


LISLO


SPPL


TAB


2.5mg


10


16.00


TAB


5mg


10


30.00


TAB


10mg


10


58.00


LISORIL


IPCA


TAB


2.5mg


10


18.90


TAB


5mg


10


34.90


TAB


10mg


10


68.90


TAB


20mg


10


134.40


LISTRIL


Torrent


TAB


2.5mg


10


18.90


TAB


5mg


10


34.90


TAB


10mg


10


68.90


LPL


Concept


TAB


2.5mg


10


13.95


TAB


5mg


10


26.87


TAB


10mg


10


51.68


NIVANT


German Remedies


TAB


2.5mg


10


13.50


TAB


5mg


10


25.10


TAB


10mg


10


50.00


TAB


20mg


10


96.40


ODACE


Alidac


TAB


5mg


10


22.22


TAB


10mg


10


45.45


TAB


2.5mg


10


15.15


PREVACE


Sertec


TAB


5mg


10


30.90


TAB


10mg


10


15.95


TAB


2.5mg


10


59.96


TOP

   



 

                                                     
                                               







 

    

   
Drug Information
  

     

Pharmacokinetics

Lisinopril is slowly absorbed after oral administration. It has 1/2 life of 7 hrs. It is excreted via the urine.

TOP
   

Indication & Dosage

Oral
ESSENTIAL AND RENAL HYPERTENSION, CONGESTIVE HEART FAILURE;
Start with 2.5mg once daily. Increase gradually according to response. Max: 40mg/day. Elderly: Very gradual dose increases with caution.

TOP
   

Action

Competetive inhibition of ACE. Reduction in levels of angiotensin II (ATII) and aldosterone. Peripheral vasodilatation and reduced peripheral resistance. Blood pressure reduction enhanced by salt and water depletion e.g excessive sweating. In patients with congestive failure, there is reduction in afterload and in pulmonary capillary wedge pressure. Cardiac efficiency is increased as is also renal blood flow.

TOP
   

Interactions 

Lithium and Indomethacin reduce hypotensive effect. Hydrochlorthiazide potentiates its effect. Co-administration of cyclo-oxygenase causes reduction in renal function.

TOP
   

Adverse Effect & Precautions
 
Diziness, cough, hyperkalaemia, headache, hypotension, angio oedema.

Allergies: Allergic reaction to Lisinopril may occur. Pregnancy: Studies in rats at doses many times the recommended human dose have shown that use of lisinopril causes a decrease in successful pregnancies, a decrease in the weight of infants, and an increase in infant deaths. It has also caused abnormal bone growth in rabbits.
Pregnancy: Contraindicated.
Breast Feeding: Use with caution
Man: May be used in reduced dose.

TOP
   

Brands available in market :

ACEBITOR

Croydon

TAB

5mg

10

35.60

TAB

10mg

10

61.26

ACETITOR

Croydon

TAB

10mg

10

61.26

ACINNOPRIL

Boehringer Mannheim

TAB

2.5mg

10

15.00

TAB

5mg

10

31.00

TAB

10mg

10

56.00

BIOPRIL

Biochem

TAB

2.5mg

10

17.10

TAB

5mg

10

32.20

TAB

10mg

10

59.36

CIPRIL

Cipla

TAB

2.5mg

10

19.35

TAB

5mg

10

35.25

TAB

10mg

10

68.35

DILACE

Orchid

TAB

5mg

10

30.00

HIPRIL

Micro Labs

TAB

2.5mg

10

17.50

TAB

5mg

10

34.80

ILIS

Recon

TAB

2.5mg

10

25.20

TAB

5mg

10

44.80

TAB

10mg

10

84.00

INRAS

Merind

TAB

2.5mg

10

20.85

TAB

5mg

10

36.50

TAB

10mg

10

76.80

LESOPRIL

Themis

TAB

5mg

10

62.50

LINVAS

Cadila Pharma

TAB

2.5mg

10

10.00

TAB

5mg

10

37.90

TAB

10mg

10

73.70

LIPRIL

Lupin

TAB

2.5mg

10

19.00

TAB

5mg

10

33.00

TAB

10mg

10

61.50

LISICARD

Gufic

TAB

2.5mg

10

19.06

TAB

5mg

10

36.05

TAB

10mg

10

70.04

LISINACE

Alkem

TAB

2.5mg

10

18.60

TAB

5mg

10

33.00

TAB

10mg

10

61.50

LISIR-5/10

Kramer

TAB

5mg

10

25.00

TAB

10mg

10

50.78

LISLO

SPPL

TAB

2.5mg

10

16.00

TAB

5mg

10

30.00

TAB

10mg

10

58.00

LISORIL

IPCA

TAB

2.5mg

10

18.90

TAB

5mg

10

34.90

TAB

10mg

10

68.90

TAB

20mg

10

134.40

LISTRIL

Torrent

TAB

2.5mg

10

18.90

TAB

5mg

10

34.90

TAB

10mg

10

68.90

LPL

Concept

TAB

2.5mg

10

13.95

TAB

5mg

10

26.87

TAB

10mg

10

51.68

NIVANT

German Remedies

TAB

2.5mg

10

13.50

TAB

5mg

10

25.10

TAB

10mg

10

50.00

TAB

20mg

10

96.40

ODACE

Alidac

TAB

5mg

10

22.22

TAB

10mg

10

45.45

TAB

2.5mg

10

15.15

PREVACE

Sertec

TAB

5mg

10

30.90

TAB

10mg

10

15.95

TAB

2.5mg

10

59.96

TOP
   

 

                                                                                                     

 

By |2022-07-20T16:42:56+00:00July 20, 2022|Uncategorized|Comments Off on Lisinopril

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