Drug Information

 


     











Pharmacokinetics

Lithium is given orally. It is well absorbed and gets
distributed throughout the total body water. The drug is excreted in the
urine.Most of the filtered lithium is reabsorbed in the proximal
convoluted tubule. Renal clearance is proportional to its plasma
clearance. It decreases the sodium re-absorption leading to sodium
depletion. Hence patients should maintain adequate salt and water
intake.Since the margin of safety is narrow monitoring the serum lithium
concenration is esssential for optimal therapy.Toxic symptoms occur
frequently when serum levels exceed 1.5 mEq/L.

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Indication
& Dosage



Oral

MILD OT MODERATE INFECTINS CAUSED BY SUSCEPTIBLE STRAINS:
400mg once daily
for 10-14 days.

GONOCOCCAL URETHRITIS OR CERVICITIS: 200-400mg a single dose.

PROPHYLAXIS BEFORE TRANS-URETHRAL SURGERY: 400mg 2-6 hours before surgery.
Elderly: No dose reduction unless renal imapirment is present. Renal
impairment: Creatinine 400mg on day 1 and 200mg/day subsequently.

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Action

Bactericidal action through inhibitionof bacterial DBA 
gyrase. Excellnet activity against enterobacteriaceae and other
Gram-negative bacilli. Gram-negative pathogens susceptible to lomefloxacin
include mMoraxella catarrhalis, Neisseria gonorrhoeae, H.influenzae
including betalactamase-producing strains and pseudomonas aeruginosa
(moderate sensitivity). Less potent against Gram-positive pathogens.
Lomefloxacin is 8 times more active than erythromycin against Chlamydia
trachomatis.

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Interactions

Antipsychotics : Blood levels of both drugs may
fluctuate, increasing the chance of serious adverse effects.
Diuretics and anti-inflammatory drugs( except narcotics) can
produce elevated blood levels of lithium. Drugs for asthma,
bronchitis, emphysema, sinusitis, or cystic fibrosis that contains
Calcium iodide, Iodinated glycerol or Potassium iodide : adverse
effects on the thyroid may occur.

TOP

  





Adverse
Effect & Precautions





Nausea,
vomiting, epigastric distress, polydipsia, polyuria, diarrhoea,
dizziness, ataxia, arrhythmias, skin rash, glycosuria and blurred
vision.


Allergies: May occur with lithium therapy.
Diet: low-sodium or low-salt diet could lead to serious side
effects. Pregnancy : Lithium is not recommended for use during
pregnancy, especially during the first 3 months. Studies have
shown that lithium may rarely cause thyroid defects and cardiac or
vascular defects in the baby. It has also been shown to cause
muscle weakness and severe drowsiness in newborn babies of mothers
taking lithium near the time of delivery. Breast-feeding: Lithium
passes into the breast milk. It has been reported to cause adverse
effects such as muscle weakness, hypothermia, and cardiac
disorders in nursing babies.

Pregnancy: Contraindicated.

Breast Feeding: Contraindicated.

Man: May be given in reduced doses.

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Brands available in market :






































FLOXADAY


Croslands


TAB


400mg


6


58.50


FOXIL


SaraBhai


TAB


400mg


10


105.55


LOMADAY


DR.Reddy


TAB


400mg


10


108.72


LOMEDON


Indon


TAB


400mg


10


113.00


LOMEF-400


Torrent


TAB


400mg


4


43.20


LOMEWON


Max


TAB


400mg


5


45.00


LOMEXEL


Medley


TAB


400mg


10


107.00


LOMFLOX-400


IPCA


TAB


400mg


4


42.40


LOMIBACT


Sun Pharma


TAB


400mg


10×4


396.00


LOMITAS


Intas


TAB


400mg


4


42.25


LOXIPEN


Morepen


TAB


400mg


5


50.00


MAHAQUIN


RPG


TAB


400mg


4


43.48


MAXALOM


SOL


TAB


400mg


4


51.53


QUMAX


Alkem


TAB


400mg


10


106.00


RELOM


Boehringer Mannheim


TAB


400mg


5


92.50


SOLOFLOX


Kopran


F-C TAB


400mg


4


36.00


TOP

  



 

                                                     
                                               







 

         


Drug Information
 

     

Pharmacokinetics

Lithium is given orally. It is well absorbed and gets distributed throughout the total body water. The drug is excreted in the urine.Most of the filtered lithium is reabsorbed in the proximal convoluted tubule. Renal clearance is proportional to its plasma clearance. It decreases the sodium re-absorption leading to sodium depletion. Hence patients should maintain adequate salt and water intake.Since the margin of safety is narrow monitoring the serum lithium concenration is esssential for optimal therapy.Toxic symptoms occur frequently when serum levels exceed 1.5 mEq/L.

TOP
  

Indication & Dosage

Oral
MILD OT MODERATE INFECTINS CAUSED BY SUSCEPTIBLE STRAINS:
400mg once daily for 10-14 days.
GONOCOCCAL URETHRITIS OR CERVICITIS: 200-400mg a single dose.
PROPHYLAXIS BEFORE TRANS-URETHRAL SURGERY: 400mg 2-6 hours before surgery. Elderly: No dose reduction unless renal imapirment is present. Renal impairment: Creatinine 400mg on day 1 and 200mg/day subsequently.

TOP
  

Action

Bactericidal action through inhibitionof bacterial DBA  gyrase. Excellnet activity against enterobacteriaceae and other Gram-negative bacilli. Gram-negative pathogens susceptible to lomefloxacin include mMoraxella catarrhalis, Neisseria gonorrhoeae, H.influenzae including betalactamase-producing strains and pseudomonas aeruginosa (moderate sensitivity). Less potent against Gram-positive pathogens. Lomefloxacin is 8 times more active than erythromycin against Chlamydia trachomatis.

TOP
  

Interactions

Antipsychotics : Blood levels of both drugs may fluctuate, increasing the chance of serious adverse effects. Diuretics and anti-inflammatory drugs( except narcotics) can produce elevated blood levels of lithium. Drugs for asthma, bronchitis, emphysema, sinusitis, or cystic fibrosis that contains Calcium iodide, Iodinated glycerol or Potassium iodide : adverse effects on the thyroid may occur.

TOP
  

Adverse Effect & Precautions

Nausea, vomiting, epigastric distress, polydipsia, polyuria, diarrhoea, dizziness, ataxia, arrhythmias, skin rash, glycosuria and blurred vision.

Allergies: May occur with lithium therapy. Diet: low-sodium or low-salt diet could lead to serious side effects. Pregnancy : Lithium is not recommended for use during pregnancy, especially during the first 3 months. Studies have shown that lithium may rarely cause thyroid defects and cardiac or vascular defects in the baby. It has also been shown to cause muscle weakness and severe drowsiness in newborn babies of mothers taking lithium near the time of delivery. Breast-feeding: Lithium passes into the breast milk. It has been reported to cause adverse effects such as muscle weakness, hypothermia, and cardiac disorders in nursing babies.
Pregnancy: Contraindicated.
Breast Feeding: Contraindicated.
Man: May be given in reduced doses.

TOP
  

Brands available in market :

FLOXADAY

Croslands

TAB

400mg

6

58.50

FOXIL

SaraBhai

TAB

400mg

10

105.55

LOMADAY

DR.Reddy

TAB

400mg

10

108.72

LOMEDON

Indon

TAB

400mg

10

113.00

LOMEF-400

Torrent

TAB

400mg

4

43.20

LOMEWON

Max

TAB

400mg

5

45.00

LOMEXEL

Medley

TAB

400mg

10

107.00

LOMFLOX-400

IPCA

TAB

400mg

4

42.40

LOMIBACT

Sun Pharma

TAB

400mg

10×4

396.00

LOMITAS

Intas

TAB

400mg

4

42.25

LOXIPEN

Morepen

TAB

400mg

5

50.00

MAHAQUIN

RPG

TAB

400mg

4

43.48

MAXALOM

SOL

TAB

400mg

4

51.53

QUMAX

Alkem

TAB

400mg

10

106.00

RELOM

Boehringer Mannheim

TAB

400mg

5

92.50

SOLOFLOX

Kopran

F-C TAB

400mg

4

36.00

TOP
  

 

                                                                                                     

 

By |2022-07-20T16:41:37+00:00July 20, 2022|Uncategorized|Comments Off on Lithium

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