Drug Information

 


    











Pharmacokinetics

Lorazepam is moderately rapidly absorbed from the
proximal small intestine. It is extensively distributed in the body. It
is transformed to clinically active metabolites. It has a moderately long
half-life[10-20 hours] and may persist in the body . It is metabolized in the liver. Clearance is reduced in liver damage.

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Indication
& Dosage

Oral

ANXIETY STATES, PSYCHOSOMATIC DISORDERS: 1-4mg daily in divided doses.
INSOMINIA DUE TO ANXIETY: 1-2mg at bedtime

PREMEDICATION FOR SURGERY: 2-3mg at night before surgery and 2-4mg 1 or 2
hrs before surgery. 2-4mg 1 or 2 hrs before surgery.

NOTE: Elderly or debilitated patients: Start at 1-2mg/day in divided doses
and adjust as required. Children under 12 yrs: Not recommended.

IM/IV

ACUTE PANIC ATTACKS: 20-30mcg/kg IM OR slow IV  after suitable
dilution. Repeated q ghrs if reqd.

PREMEDICATION: Slow IV 50mcg/kg after dilution 30-45 mins before
operation.

STATUS EPILEPTICUS: IV inj 4mg. Children: IV 2mg.

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Action

A benzodiazepine anxiolytic. It has no appreciable
effect on respiratory or cardiovascular systems. Some degree of sedation
which is dose-related. Actions are the results of facilitative effect on
GABA activity/.

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Interactions

Precaution has to be taken in severe
hepatic&renal dysfunction, acute narrow angle glaucoma,
pulmonary insufficiency and children below 6 years of age.

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Adverse
Effect & Precautions






Anorexia,
nausea, sedation, hypersensitivy reaction. It has a capacity to
induce dependence and with drawal of drug can be difficult.
Sedation, weakness, impaired alertness, amnesia, tolerance.


Precaution has to be taken in severe hepatic&renal
dysfunction, acute narrow angle glaucoma, pulmonary insufficiency
and children below 6 years of age.

Pregnancy: Contraindicated.

Breast Feeding: Contraindicated.

Man: May be given in reduced dose.

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Brands available in market :























ATIVAN


Wyeth Lederle


TAB


1mg


10


6.39


TAB


2mg


10


8.16


CALMESE


Themis Chemicals


TAB


1mg


10


163.00


TAB


2mg


10


213.75


INJ


2mg/ml


10


118.00


LARPOSE


Cipla


TAB


1mg


10


7.05


TAB


2mg


10


9.15


TRAPEX


Sun Pharma


TAB


1mg


10


6.00


TAB


2mg


10


9.00


ZEPNAP


La Pharma


TAB


1mg


10


5.90


TAB


2mg


10


3.00


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Drug Information
 

    

Pharmacokinetics

Lorazepam is moderately rapidly absorbed from the proximal small intestine. It is extensively distributed in the body. It is transformed to clinically active metabolites. It has a moderately long half-life[10-20 hours] and may persist in the body . It is metabolized in the liver. Clearance is reduced in liver damage.

TOP
   

Indication & Dosage

Oral
ANXIETY STATES, PSYCHOSOMATIC DISORDERS: 1-4mg daily in divided doses. INSOMINIA DUE TO ANXIETY: 1-2mg at bedtime
PREMEDICATION FOR SURGERY: 2-3mg at night before surgery and 2-4mg 1 or 2 hrs before surgery. 2-4mg 1 or 2 hrs before surgery.
NOTE: Elderly or debilitated patients: Start at 1-2mg/day in divided doses and adjust as required. Children under 12 yrs: Not recommended.
IM/IV
ACUTE PANIC ATTACKS: 20-30mcg/kg IM OR slow IV  after suitable dilution. Repeated q ghrs if reqd.
PREMEDICATION: Slow IV 50mcg/kg after dilution 30-45 mins before operation.
STATUS EPILEPTICUS: IV inj 4mg. Children: IV 2mg.

TOP
   

Action

A benzodiazepine anxiolytic. It has no appreciable effect on respiratory or cardiovascular systems. Some degree of sedation which is dose-related. Actions are the results of facilitative effect on GABA activity/.

TOP
   

Interactions

Precaution has to be taken in severe hepatic&renal dysfunction, acute narrow angle glaucoma, pulmonary insufficiency and children below 6 years of age.

TOP
   

Adverse Effect & Precautions

Anorexia, nausea, sedation, hypersensitivy reaction. It has a capacity to induce dependence and with drawal of drug can be difficult. Sedation, weakness, impaired alertness, amnesia, tolerance.
Precaution has to be taken in severe hepatic&renal dysfunction, acute narrow angle glaucoma, pulmonary insufficiency and children below 6 years of age.
Pregnancy: Contraindicated.
Breast Feeding: Contraindicated.
Man: May be given in reduced dose.

TOP
   

 
Brands available in market :

ATIVAN

Wyeth Lederle

TAB

1mg

10

6.39

TAB

2mg

10

8.16

CALMESE

Themis Chemicals

TAB

1mg

10

163.00

TAB

2mg

10

213.75

INJ

2mg/ml

10

118.00

LARPOSE

Cipla

TAB

1mg

10

7.05

TAB

2mg

10

9.15

TRAPEX

Sun Pharma

TAB

1mg

10

6.00

TAB

2mg

10

9.00

ZEPNAP

La Pharma

TAB

1mg

10

5.90

TAB

2mg

10

3.00

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By |2022-07-20T16:42:55+00:00July 20, 2022|Uncategorized|Comments Off on Lorazepam

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