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Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interactions
Adverse
Effect & Precautions |
Brands available in Market
Pharmacokinetics
Well aborbed orally, undergoes substantial first passmetabolism with a
biavialability of approxiamately 33%. About 40% of an orally
administered dose is converted to an active carboxylic acid metabolite
that is responsible for most of angiotensis II antagonism, Biliary
excretion contributes to the eliminationof losartan and its metabolite.
About 35% of the dose is recovered in the urine and 65% in the faeces.
Oral
HYPERTENSION: Usual initial dose is 50mg once daily, with 25mg advised in
patients with hepatic dysfunction or volume depletion. If the
antihypertensive response at through is not satisfactory, an increase in
dose or twice daily dose may give the desired response. Usual total daily
dose range is 25-100mg. No initial dosage adjustment is necessary in the
elderly and in patients with mild to moderate renal impairment.
Losartan is an angiotensin II receptor (type AT1) antagonist antihypertensive which acts by blocking the actions of angiotensin II of renin-angiotensin-aldosterone system. The drug and its active metabolite selectively block the vasoconstrictor and aldosterone secreting effects of angiotensin II by selectively antagonising the binding of angiotensin II to AT1 receptors. Neither Iosartan nor its metabolite inhibits ACE (kininase II); this could explain (because of noninterference with metabolism of bradykinin) the absence of cough experienced with losartan therapy is comparable to that of placebo.
Interactions
Diuretics, other antihypertensives: Potentiate the hypotensive
effect of losartan. Potassium sparing diuretics,
Potassium supplements: Risk of hyperkalaemia.
NSAIDs: May blunt hypotensive effect of losartan.
Cytochrome P450 inhibiotors like ketoconazole: Increase in AUC of
losartan by 18% but has no effect onits active metabolite.
Phenobarbital: Results in 20% reduction in AUC losartan and its
active metabolite.
Adverse
Effect & Precautions
Headache,
dizziness, asthenia or fatigue. Rarely angiodema, first dose
hypotension, transiet elevation of liver transaminases and hyper
kalaemia.
Precaution:
Patients who are intravascularly volume depleted, renal artery
stenosis. Monitor serum potassium concentrations especially in
elderly patients or those with renal impairment. Avoid concomitant
use of potassium sparing diuretics.
Pregnancy: Contraindicated.
Breast Feeding: Contraindicated.
Man: May be used in reduced dose.
ANGIZAAR
Micro Labs
TAB
25mg
10
27.31
TAB
50mg
10
48.77
COVANCE
Ranbaxy
FC-TABS
25mg
10
40.30
F-C TABS
50mg
10
67.50
LOSACAR
Cadila Healthcare
TAB
25mg
7
26.60
TAB
50mg
7
13.65
LOSAR
Unisearch
TAB
25mg
10
36.00
TAB
50mg
10
66.60
LOSARTAS
Intas
TAB
25mg
1
2.00
TAB
50mg
1
3.80
MYOTAN
Unique
TAB
25mg
10
35.23
TAB
50mg
10
70.46
RELISCO
Dr. Reddy’s
TAB
25mg
10
18.90
TAB
50mg
10
37.44
REPACE
Sun
TAB
25mg
10
39.00
TAB
50mg
10
70.00
TOZAAR
Torrent
TAB
25mg
10
35.00
TAB
50mg
10
63.00
