Drug Information

 
   



     











Pharmacokinetics

 

Well aborbed orally, undergoes substantial first passmetabolism with a
biavialability of approxiamately 33%. About 40% of an orally
administered dose is converted to an active carboxylic acid metabolite
that is responsible for most of angiotensis II antagonism, Biliary
excretion contributes to the eliminationof losartan and its metabolite.
About 35% of the dose is recovered in the urine and 65% in the faeces.

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Indication
& Dosage

Oral

HYPERTENSION: Usual initial dose is 50mg once daily, with 25mg advised in
patients with hepatic dysfunction or volume depletion. If the
antihypertensive response at through is not satisfactory, an increase in
dose or twice daily dose may give the desired response. Usual total daily
dose range is 25-100mg. No initial dosage adjustment is necessary in the
elderly and in patients with mild to moderate renal impairment.

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Action

Losartan is an angiotensin II receptor (type AT1)
antagonist antihypertensive which acts by blocking the actions of
angiotensin II of renin-angiotensin-aldosterone system. The drug and its
active metabolite selectively block the vasoconstrictor and aldosterone
secreting effects of angiotensin II  by selectively antagonising the
binding of angiotensin II to AT1 receptors. Neither Iosartan nor its
metabolite inhibits ACE (kininase II); this could explain (because of
noninterference with metabolism of bradykinin) the absence of cough experienced with losartan therapy is comparable to that of placebo.

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Interactions





Diuretics, other antihypertensives: Potentiate the hypotensive
effect of losartan. Potassium sparing diuretics, 

Potassium supplements: Risk of hyperkalaemia.

NSAIDs: May blunt hypotensive effect of losartan.

Cytochrome P450 inhibiotors like ketoconazole: Increase in AUC of
losartan by 18% but has no effect onits active metabolite.

Phenobarbital: Results in 20% reduction in AUC losartan and its
active metabolite.

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Adverse
Effect & Precautions





Headache,
dizziness, asthenia or fatigue. Rarely angiodema, first dose
hypotension, transiet elevation of liver transaminases and hyper
kalaemia.

Precaution:
Patients who are intravascularly volume depleted, renal artery
stenosis. Monitor serum potassium concentrations especially in
elderly patients or those with renal impairment. Avoid concomitant
use of potassium sparing diuretics.

Pregnancy: Contraindicated.

Breast Feeding: Contraindicated.

Man: May be used in reduced dose.

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Brands available in market :

































ANGIZAAR


Micro Labs


TAB


25mg


10


27.31


TAB


50mg


10


48.77


COVANCE


Ranbaxy


FC-TABS


25mg


10


40.30


F-C TABS


50mg


10


67.50


LOSACAR


Cadila Healthcare


TAB


25mg


7


26.60


TAB


50mg


7


13.65


LOSAR


Unisearch


TAB


25mg


10


36.00


TAB


50mg


10


66.60


LOSARTAS


Intas


TAB


25mg


1


2.00


TAB


50mg


1


3.80


MYOTAN


Unique


TAB


25mg


10


35.23


TAB


50mg


10


70.46


RELISCO


Dr. Reddy’s


TAB


25mg


10


18.90


TAB


50mg


10


37.44


REPACE


Sun


TAB


25mg


10


39.00


TAB


50mg


10


70.00


TOZAAR


Torrent


TAB


25mg


10


35.00


TAB


50mg


10


63.00




  


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Drug Information
     

     

Pharmacokinetics
 
Well aborbed orally, undergoes substantial first passmetabolism with a biavialability of approxiamately 33%. About 40% of an orally administered dose is converted to an active carboxylic acid metabolite that is responsible for most of angiotensis II antagonism, Biliary excretion contributes to the eliminationof losartan and its metabolite. About 35% of the dose is recovered in the urine and 65% in the faeces.

TOP
   

Indication & Dosage

Oral
HYPERTENSION: Usual initial dose is 50mg once daily, with 25mg advised in patients with hepatic dysfunction or volume depletion. If the antihypertensive response at through is not satisfactory, an increase in dose or twice daily dose may give the desired response. Usual total daily dose range is 25-100mg. No initial dosage adjustment is necessary in the elderly and in patients with mild to moderate renal impairment.

TOP
   

Action

Losartan is an angiotensin II receptor (type AT1) antagonist antihypertensive which acts by blocking the actions of angiotensin II of renin-angiotensin-aldosterone system. The drug and its active metabolite selectively block the vasoconstrictor and aldosterone secreting effects of angiotensin II  by selectively antagonising the binding of angiotensin II to AT1 receptors. Neither Iosartan nor its metabolite inhibits ACE (kininase II); this could explain (because of noninterference with metabolism of bradykinin) the absence of cough experienced with losartan therapy is comparable to that of placebo.

TOP
   

Interactions

Diuretics, other antihypertensives: Potentiate the hypotensive effect of losartan. Potassium sparing diuretics, 
Potassium supplements: Risk of hyperkalaemia.
NSAIDs: May blunt hypotensive effect of losartan.
Cytochrome P450 inhibiotors like ketoconazole: Increase in AUC of losartan by 18% but has no effect onits active metabolite.
Phenobarbital: Results in 20% reduction in AUC losartan and its active metabolite.

TOP
   

Adverse Effect & Precautions

Headache, dizziness, asthenia or fatigue. Rarely angiodema, first dose hypotension, transiet elevation of liver transaminases and hyper kalaemia.

Precaution: Patients who are intravascularly volume depleted, renal artery stenosis. Monitor serum potassium concentrations especially in elderly patients or those with renal impairment. Avoid concomitant use of potassium sparing diuretics.
Pregnancy: Contraindicated.
Breast Feeding: Contraindicated.
Man: May be used in reduced dose.

TOP
   

 
Brands available in market :

ANGIZAAR

Micro Labs

TAB

25mg

10

27.31

TAB

50mg

10

48.77

COVANCE

Ranbaxy

FC-TABS

25mg

10

40.30

F-C TABS

50mg

10

67.50

LOSACAR

Cadila Healthcare

TAB

25mg

7

26.60

TAB

50mg

7

13.65

LOSAR

Unisearch

TAB

25mg

10

36.00

TAB

50mg

10

66.60

LOSARTAS

Intas

TAB

25mg

1

2.00

TAB

50mg

1

3.80

MYOTAN

Unique

TAB

25mg

10

35.23

TAB

50mg

10

70.46

RELISCO

Dr. Reddy’s

TAB

25mg

10

18.90

TAB

50mg

10

37.44

REPACE

Sun

TAB

25mg

10

39.00

TAB

50mg

10

70.00

TOZAAR

Torrent

TAB

25mg

10

35.00

TAB

50mg

10

63.00

  

TOP
   

                                                                                                     

 

By |2022-07-20T16:42:56+00:00July 20, 2022|Uncategorized|Comments Off on Losartan Potassium

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