Drug Information

    


      











Pharmacokinetics



After oral administration it is extensively metabolised in liver. the
plasma concentration is 2/3 lower when given under fasting conditions.

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Indication
& Dosage


 



Oral

REDUCTION OF ELEVATED CHOLESTEROL IN PATIENTS WITH PRIMARY
HYPERCHOLESTEROLAEMIA (TYPES IIA AND IIB), COMBINED HPERCHOLESTERALAEMIA:

Usually 20mg once daily with evening meal. Max 80mg/day in divided doses.

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Action

Reduces cholesterol synthesis by inhibiting a
rate-limiting step catalysed by 3-hydroxy-3-methylglutaryl Coenzynme A
Reductase (HMG CoA reductase). Action is mainly in the liver and results
in increase of hepatic LDL RECEPTORS. There is increased removal of LDL
from the circulation.

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Interactions



Cyclosporine, erythromycin, niacin, gemfibrozil: Severe myopathy
or rhabdomyolysis

Propranolol: Decrease in antihyperlipidaemic activity.

Itraconazole: Plasma levels of lovastatin increased 20-fold.

Warfarin: ANticoagulant effect increased, chances of bleeding.

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Adverse
Effect & Precautions





Arthralgia, myopathy, vertigo, tremor, memory loss, alterationof
taste, peripheral neuropathy, anxiety, depression, insomnia.
Hepatitis cholestatic jaundice, pancreatitis, anorexia, heartburn,
abdominal pain, pruritis, alopecia, blurred vision, progression of
cataract.



Precaution: Alcoholics, renal impairment, use in children less
than 2 years is not recommended, Previous history of liver
disease.

Pregnancy: Contraindicated.

Breast Feeding: Contraindicated.

Man: Use with caution.

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Brands available in market :





















































AZTATIN


Sun Pharma


TAB


10mg


10


31.00


TAB


20mg


10


55.50


ELSTATIN


Glenmark


TAB


10mg


10


50.00


TAB


20mg


10


80.00


FAVOLIP


SPPL


TAB


10mg


10


60.00


TAB


20mg


10


102.50


LESTRIC


Solus


TAB


10mg


10


120.00


TAB


20mg


10


210.00


LIPDIP


Kee Pharma


TAB


20mg


10


85.00


LIPISTAT


RPG


TAB


10mg


10


59.50


TAB


20mg


10


109.52


LOCHOL


Micro Labs


TAB


20mg


10


128.00


LOSTATIN


Dr.Reddy’s


TAB


20mg


10


49.95


TAB


10mg


10


29.97


LOTIN


Altima


TAB


10mg


10


35.00


TAB


20mg


10


70.00


LOVADAC


Cadila Healthcare


TAB


20mg


10


125.00


TAB


10mg


10


75.00


LOVALIP


Cadila Pharma


TAB


10mg


10


77.00


TAB


20mg


10


130.00


LOVAMEG


Alembic


TAB


20mg


10


110.70


LOVASTAT


Torrent


TAB


20mg


10


120.00


LOVASTROL


Medley


TAB


20mg


10


98.00


PRO HDL


Wockhardt


TAB


10mg


10


38.50


TAB


20mg


10


66.50


RECOL


Themis Chemicals


TAB


10mg


10


27.65


TAB


20mg


10


45.25


TAB


40mg


10


125.00


ROVACOR-20


Stancare


TAB


20mg


10


105.70


TOP

   



 

                                                
                                               






     

   
Drug Information
    

      

Pharmacokinetics

After oral administration it is extensively metabolised in liver. the plasma concentration is 2/3 lower when given under fasting conditions.

TOP
   

Indication & Dosage
 

Oral
REDUCTION OF ELEVATED CHOLESTEROL IN PATIENTS WITH PRIMARY HYPERCHOLESTEROLAEMIA (TYPES IIA AND IIB), COMBINED HPERCHOLESTERALAEMIA:
Usually 20mg once daily with evening meal. Max 80mg/day in divided doses.

TOP
   

Action

Reduces cholesterol synthesis by inhibiting a rate-limiting step catalysed by 3-hydroxy-3-methylglutaryl Coenzynme A Reductase (HMG CoA reductase). Action is mainly in the liver and results in increase of hepatic LDL RECEPTORS. There is increased removal of LDL from the circulation.

TOP
   

Interactions

Cyclosporine, erythromycin, niacin, gemfibrozil: Severe myopathy or rhabdomyolysis
Propranolol: Decrease in antihyperlipidaemic activity.
Itraconazole: Plasma levels of lovastatin increased 20-fold.
Warfarin: ANticoagulant effect increased, chances of bleeding.

TOP
   

Adverse Effect & Precautions

Arthralgia, myopathy, vertigo, tremor, memory loss, alterationof taste, peripheral neuropathy, anxiety, depression, insomnia. Hepatitis cholestatic jaundice, pancreatitis, anorexia, heartburn, abdominal pain, pruritis, alopecia, blurred vision, progression of cataract.

Precaution: Alcoholics, renal impairment, use in children less than 2 years is not recommended, Previous history of liver disease.
Pregnancy: Contraindicated.
Breast Feeding: Contraindicated.
Man: Use with caution.

TOP
   

Brands available in market :

AZTATIN

Sun Pharma

TAB

10mg

10

31.00

TAB

20mg

10

55.50

ELSTATIN

Glenmark

TAB

10mg

10

50.00

TAB

20mg

10

80.00

FAVOLIP

SPPL

TAB

10mg

10

60.00

TAB

20mg

10

102.50

LESTRIC

Solus

TAB

10mg

10

120.00

TAB

20mg

10

210.00

LIPDIP

Kee Pharma

TAB

20mg

10

85.00

LIPISTAT

RPG

TAB

10mg

10

59.50

TAB

20mg

10

109.52

LOCHOL

Micro Labs

TAB

20mg

10

128.00

LOSTATIN

Dr.Reddy’s

TAB

20mg

10

49.95

TAB

10mg

10

29.97

LOTIN

Altima

TAB

10mg

10

35.00

TAB

20mg

10

70.00

LOVADAC

Cadila Healthcare

TAB

20mg

10

125.00

TAB

10mg

10

75.00

LOVALIP

Cadila Pharma

TAB

10mg

10

77.00

TAB

20mg

10

130.00

LOVAMEG

Alembic

TAB

20mg

10

110.70

LOVASTAT

Torrent

TAB

20mg

10

120.00

LOVASTROL

Medley

TAB

20mg

10

98.00

PRO HDL

Wockhardt

TAB

10mg

10

38.50

TAB

20mg

10

66.50

RECOL

Themis Chemicals

TAB

10mg

10

27.65

TAB

20mg

10

45.25

TAB

40mg

10

125.00

ROVACOR-20

Stancare

TAB

20mg

10

105.70

TOP
   

 

                                                                                                

By |2022-07-20T16:42:58+00:00July 20, 2022|Uncategorized|Comments Off on Lovastatin

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