Drug Information

  


      











Pharmacokinetics



Readily abosrbed form the GI tract even in the presence of severe
diarrhoea. It is widely distributed in the tissues and is eliminated
very slowly.

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Indication
& Dosage


 




Oral

MULTIPLE MYELOMA:
Several regimens have been recommended. One regimen is
start 6mg/day as a single dose daily, adjusted according to weekly blood
counts. After 2-3 weeks discontinue for 4 weeks and start maintenance
dose at 2mg/kg

ADVANCED OVARIAN CANCER: 0.2mg/kg daily for 5 days. This course can be
repeated every 4-5 weeks.



IV

MYELOMAS, SOLID TUMORS, LYMPHOMAS: 16mg/m2 as an IV infusion over 15-20
mins. Repeat at 2 week intervals for 4 doses followed by 4-week
intervals.

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Action

 


An alkylating agent active against some malignancies. It is active
against both resting and rapidly dividing cells. 

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Interactions

 

Primaquine: Serum concentrations of primaquine increased resulting
intoxicity.

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Adverse
Effect & Precaution




Urticaria, exfoliative dermatitis, GI disturbances, dizziness, yelow
discolorationof the skinon prolonged use.



Precaution: Hepatic disease, psychosis.

Pregnancy: Use with caution.

Breast Feeding: Contraindicated.

Man: Use with caution.

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Brand
available in market


 










MALADIN

Unicure

TAB

100mg

10

21.25

TAB

300mg

10

64.25




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Drug Information
  

      

Pharmacokinetics

Readily abosrbed form the GI tract even in the presence of severe diarrhoea. It is widely distributed in the tissues and is eliminated very slowly.

TOP
  

Indication & Dosage
 

Oral
MULTIPLE MYELOMA:
Several regimens have been recommended. One regimen is start 6mg/day as a single dose daily, adjusted according to weekly blood counts. After 2-3 weeks discontinue for 4 weeks and start maintenance dose at 2mg/kg
ADVANCED OVARIAN CANCER: 0.2mg/kg daily for 5 days. This course can be repeated every 4-5 weeks.

IV
MYELOMAS, SOLID TUMORS, LYMPHOMAS: 16mg/m2 as an IV infusion over 15-20 mins. Repeat at 2 week intervals for 4 doses followed by 4-week intervals.

TOP
   

Action
 

An alkylating agent active against some malignancies. It is active against both resting and rapidly dividing cells. 

TOP
  

Interactions
 
Primaquine: Serum concentrations of primaquine increased resulting intoxicity.

TOP
  

Adverse Effect & Precaution

Urticaria, exfoliative dermatitis, GI disturbances, dizziness, yelow discolorationof the skinon prolonged use.

Precaution: Hepatic disease, psychosis.
Pregnancy: Use with caution.
Breast Feeding: Contraindicated.
Man: Use with caution.

TOP

 

MALADIN

Unicure

TAB

100mg

10

21.25

TAB

300mg

10

64.25

TOP

  

                                                                                                      

 

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