|
Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interacations |
Precautions
|
Brands available in Market
Pharmacokinetics
Readily abosrbed form the GI tract even in the presence of severe
diarrhoea. It is widely distributed in the tissues and is eliminated
very slowly.
Indication
& Dosage
Oral
MULTIPLE MYELOMA: Several regimens have been recommended. One regimen is
start 6mg/day as a single dose daily, adjusted according to weekly blood
counts. After 2-3 weeks discontinue for 4 weeks and start maintenance
dose at 2mg/kg
ADVANCED OVARIAN CANCER: 0.2mg/kg daily for 5 days. This course can be
repeated every 4-5 weeks.
IV
MYELOMAS, SOLID TUMORS, LYMPHOMAS: 16mg/m2 as an IV infusion over 15-20
mins. Repeat at 2 week intervals for 4 doses followed by 4-week
intervals.
Action
An alkylating agent active against some malignancies. It is active
against both resting and rapidly dividing cells.
Adverse
Effect & Precaution
Urticaria, exfoliative dermatitis, GI disturbances, dizziness, yelow
discolorationof the skinon prolonged use.
Precaution: Hepatic disease, psychosis.
Pregnancy: Use with caution.
Breast Feeding: Contraindicated.
Man: Use with caution.
MALADIN
Unicure
TAB
100mg
10
21.25
TAB
300mg
10
64.25
