Drug Information

 


    











 

Pharmacokinetics

 


Mephentermine acts
in about 5 to 15 minutes following intramuscular injection and has a
duration of action of up to about 4 hours; it acts almost immediately
following intravenous injection with a duration of action of up to about
30 minutes. It is rapidly metabolised in the body by demethylation;
hydroxylation may follow. It is excreted as unchanged drug and
metabolites in the urine; excretion is more rapid in acidic urine.


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Indication
& Dosage






Oral

LOW BLOOD PRESSURE:
20mg once or twice daily.



IV Infusion

SHOCK:
IN MI, SPINAL ANAESTHESIA, SURGICAL PROCEDURES AND SEVERE
ILLNESS: 15-60mg IV drip 5% dextrose


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Action

 



Acts by release of noradrenaline at the adrenergic synapsi. Cardiac
output and systolic and diastolic pressures are increased and there is
peripheral vasoconstriction. Coronary blood flow is increased and
occasionallly there may even be perpheral vasodilation. 


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Interactions

  

Cyclopropane & Halothane: May result in serious ventricular
arrhythmias.

Digitalis: Increased reisk of cardiac arrhythmias.

Phenothiaziness, TCAs: May antagonise pressor response of 
nephentermine.

MAOIs: Potentiate pressor effects of mephentermine.

Oxytotic drugs: May cause severe persistent hypertension. 


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Precaution



Shock due to loss of blood or fluid.

Pregnancy: Use with caution.

Breast Feeding: Use with caution.

Man: Use with caution.


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Brand
available in market


 









MEPHENTINE

Wyeth Ledele
TAB 10mg 20 32.60
INJ 15mg/ml 1ml 5.30
INJ 15mg/ml 5x1ml 35.00
VIAL 30mg/ml 10ml 68.75







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Drug Information
 

    

 
Pharmacokinetics
 

Mephentermine acts in about 5 to 15 minutes following intramuscular injection and has a duration of action of up to about 4 hours; it acts almost immediately following intravenous injection with a duration of action of up to about 30 minutes. It is rapidly metabolised in the body by demethylation; hydroxylation may follow. It is excreted as unchanged drug and metabolites in the urine; excretion is more rapid in acidic urine.

TOP
    

Indication & Dosage

Oral
LOW BLOOD PRESSURE:
20mg once or twice daily.

IV Infusion
SHOCK:
IN MI, SPINAL ANAESTHESIA, SURGICAL PROCEDURES AND SEVERE ILLNESS: 15-60mg IV drip 5% dextrose

TOP
   

Action
 

Acts by release of noradrenaline at the adrenergic synapsi. Cardiac output and systolic and diastolic pressures are increased and there is peripheral vasoconstriction. Coronary blood flow is increased and occasionallly there may even be perpheral vasodilation. 

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Interactions
  
Cyclopropane & Halothane: May result in serious ventricular arrhythmias.
Digitalis: Increased reisk of cardiac arrhythmias.
Phenothiaziness, TCAs: May antagonise pressor response of  nephentermine.
MAOIs: Potentiate pressor effects of mephentermine.
Oxytotic drugs: May cause severe persistent hypertension. 

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Precaution

Shock due to loss of blood or fluid.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: Use with caution.

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MEPHENTINE

Wyeth Ledele

TAB

10mg

20

32.60

INJ

15mg/ml

1ml

5.30

INJ

15mg/ml

5x1ml

35.00

VIAL

30mg/ml

10ml

68.75


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By |2022-07-20T16:42:53+00:00July 20, 2022|Uncategorized|Comments Off on Mephentermine

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