Drug Information

 


     











Pharmacokinetics



After oral administration absorption is incomplete and the drug is
metabolised in liver. The active metabolites have longer half life than
parent drug.

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Indication
& Dosage





Oral

ACUTE LYMPHATIC LEUKAEMIA INCLUDING LYMPHOCYTIC AND LYMPHOBLASTIC
SUBTYPES. INDIUCTIONOF REMISSION AND MAINTENANCE. Usual initial dose for
adults an dchildren is 2.5mg/kg/day. May be continued for several weeks.
If after 4 weeks there in no response, dose may be increased to
5mg/kg/day. 

ACUTE MYELOGENOUS AND MYELOMONOCYTIEC LEUKAEMIA: Maintenance doses vary
between 1.5 an d2.5mg/kg/day as a single dose. Dosage of mercaptopurine
should be reduced to 1/4 of the usual dose if allopurinol is given
concurrently.

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Action

 


Inhibits nucleic acid bisynthesis and is active against leukaemias. 

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Interactions

 


Allopruinol: Delayed catabolism of mercaptopurine resulting in severe
toxicity. Dose of mercaptopurine should be reduced to one third to one
quarter of usual dose.

Other myelosuppressive agents: Enhance anti-neoplastic effect of
mercaptopurine, dose of mercaptoppurine may need ot be reudced.

Trimthoprim-sulfamethozazole: May result in enhanced bonemarrow
suppression.

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Adverse
Effect & Precaution





Nausea, vomiting, diarrhoea, cholestasis, bone marrow depression,
pancreatitis, oral and intesitna ulcers. Rarely hepatic necrosis.



Precaution: Impaired renal or hepatic function, monitor uric acid
levels, blood counts and hepatic function.

Pregnancy: Use with caution.

Breast Feeding: Use with caution.

Man: Use with caution

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Brand
available in market


 













EMPURINE

Dabur
TAB 50mg 10 114.00
MERCAPTHOL

Arvind Remedies
TAB 50mg 10 75.00
PURI-NETHOL

Burroughs Wellcome
TAB 50mg 25 201.18
PURINETONE

VHB
TAB 50mg 25 184.00





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Drug Information
 

     

Pharmacokinetics

After oral administration absorption is incomplete and the drug is metabolised in liver. The active metabolites have longer half life than parent drug.

TOP
   

Indication & Dosage

Oral
ACUTE LYMPHATIC LEUKAEMIA INCLUDING LYMPHOCYTIC AND LYMPHOBLASTIC SUBTYPES. INDIUCTIONOF REMISSION AND MAINTENANCE. Usual initial dose for adults an dchildren is 2.5mg/kg/day. May be continued for several weeks. If after 4 weeks there in no response, dose may be increased to 5mg/kg/day. 
ACUTE MYELOGENOUS AND MYELOMONOCYTIEC LEUKAEMIA: Maintenance doses vary between 1.5 an d2.5mg/kg/day as a single dose. Dosage of mercaptopurine should be reduced to 1/4 of the usual dose if allopurinol is given concurrently.

TOP
   

Action
 

Inhibits nucleic acid bisynthesis and is active against leukaemias. 

TOP
   

Interactions
 

Allopruinol: Delayed catabolism of mercaptopurine resulting in severe toxicity. Dose of mercaptopurine should be reduced to one third to one quarter of usual dose.
Other myelosuppressive agents: Enhance anti-neoplastic effect of mercaptopurine, dose of mercaptoppurine may need ot be reudced.
Trimthoprim-sulfamethozazole: May result in enhanced bonemarrow suppression.

TOP
   

Adverse Effect & Precaution

Nausea, vomiting, diarrhoea, cholestasis, bone marrow depression, pancreatitis, oral and intesitna ulcers. Rarely hepatic necrosis.

Precaution: Impaired renal or hepatic function, monitor uric acid levels, blood counts and hepatic function.
Pregnancy: Use with caution.
Breast Feeding: Use with caution.
Man: Use with caution

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EMPURINE

Dabur

TAB

50mg

10

114.00

MERCAPTHOL

Arvind Remedies

TAB

50mg

10

75.00

PURI-NETHOL

Burroughs Wellcome

TAB

50mg

25

201.18

PURINETONE

VHB

TAB

50mg

25

184.00

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By |2022-07-20T16:41:42+00:00July 20, 2022|Uncategorized|Comments Off on Mercaptopurine

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