Drug Information

 


   











 

Pharmacokinetics

 


Metformin hydrochloride is slowly and incompletely absorbed from the
gastrointestinal tract; the absolute bioavailability of a single 500-mg
dose is reported to be about 50 to 60%, although this is reduced
somewhat if taken with food. Following absorption plasma protein binding
is negligible, and it is excreted unchanged in the urine. The plasma
elimination half-life is reported to range from about 2 to 6 hours after
oral administration.

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Indication
& Dosage


 



Oral

NON INSULIN-DEPENDENT DIABETICS ESPECIALLY OBESE, PRIMARY OR SECONDARY
SULPHONYLUREA FAILURE, SELECTED PATIENTS WITH TYPE-1 DIABETES AS ADJUNCT
TO INSULIN THERAPY: 500mg t.i.d. with meals. May be increased upto
3g/day. Maintenance: 500-1000mg/day. Metformin may be combined with
sulphonylureas.

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Action

 

Does not increase basal or meal-induced insulin secretion. Extra
pancreatic actions include delayed intestinal abosrption of sugars and
starches, reduction of hepatic glucose produce, potentiation of insulin
actions and increased peripheral utilisation of glucose. Does not cause
hypoglycaemia or weight gain.

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Interactions

 


Use of a biguanide
concomitantly with other drugs that lower blood-glucose concentrations
increases the risk of hypoglycaemia, while drugs that increase blood
glucose may reduce the effect of biguanide therapy.

In general fewer drug interactions have been reported with biguanides
than with sulphonylureas. Alcohol may increase the risk of lactic
acidosis as well as of hypoglycaemia. Care should be taken if biguanides
are given concomitantly with drugs that may impair renal function.

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Adverse
Effect & Precaution




Nausea, vomiting, flatulence, anorexia, latic acidosis, tolerance.



Precaution: Alcohol not to be taken as interaction occurs with metformin.

Pregnancy: Safety not established,

Breast Feeding: Discontinue nursing or drug.

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Brand
available in market


 





























DIAFORMIN

Sertec

TAB

500mg

10

6.30

DIAFORMIN 500

CFL

TAB

500mg

10

7.20

DIAFORMIN 850

CFL

TAB

850mg

10

11.40

DIAMET

Bal Pharma

TAB

500mg

10

6.25

DIFORM

LA Pharma

TABS

500mg

10

6.25

TABS

850mg

10

10.65

GLUFORMIN

Boehringer Mannheim

TAB

500mg

10

6.50

GLYCIPHAGE

Franco-Indian

TAB

500mg

10

6.30

GLYCOMET

USV

TAB

500mg

10

7.25

TAB

250mg

10

4.63

METMIN

Jenburkt

TAB

500mg

10

6.40

WALAPHAGE

Wallace

TAB

500mg

10

7.20

TAB

850mg

10

11.40




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Drug Information
 

   

 
Pharmacokinetics
 

Metformin hydrochloride is slowly and incompletely absorbed from the gastrointestinal tract; the absolute bioavailability of a single 500-mg dose is reported to be about 50 to 60%, although this is reduced somewhat if taken with food. Following absorption plasma protein binding is negligible, and it is excreted unchanged in the urine. The plasma elimination half-life is reported to range from about 2 to 6 hours after oral administration.

TOP
      

Indication & Dosage
 

Oral
NON INSULIN-DEPENDENT DIABETICS ESPECIALLY OBESE, PRIMARY OR SECONDARY SULPHONYLUREA FAILURE, SELECTED PATIENTS WITH TYPE-1 DIABETES AS ADJUNCT TO INSULIN THERAPY: 500mg t.i.d. with meals. May be increased upto 3g/day. Maintenance: 500-1000mg/day. Metformin may be combined with sulphonylureas.

TOP
   

Action
 
Does not increase basal or meal-induced insulin secretion. Extra pancreatic actions include delayed intestinal abosrption of sugars and starches, reduction of hepatic glucose produce, potentiation of insulin actions and increased peripheral utilisation of glucose. Does not cause hypoglycaemia or weight gain.

TOP
   

Interactions
 

Use of a biguanide concomitantly with other drugs that lower blood-glucose concentrations increases the risk of hypoglycaemia, while drugs that increase blood glucose may reduce the effect of biguanide therapy.
In general fewer drug interactions have been reported with biguanides than with sulphonylureas. Alcohol may increase the risk of lactic acidosis as well as of hypoglycaemia. Care should be taken if biguanides are given concomitantly with drugs that may impair renal function.

TOP
   

Adverse Effect & Precaution

Nausea, vomiting, flatulence, anorexia, latic acidosis, tolerance.

Precaution: Alcohol not to be taken as interaction occurs with metformin.
Pregnancy: Safety not established,
Breast Feeding: Discontinue nursing or drug.

TOP
   

DIAFORMIN

Sertec

TAB

500mg

10

6.30

DIAFORMIN 500

CFL

TAB

500mg

10

7.20

DIAFORMIN 850

CFL

TAB

850mg

10

11.40

DIAMET

Bal Pharma

TAB

500mg

10

6.25

DIFORM

LA Pharma

TABS

500mg

10

6.25

TABS

850mg

10

10.65

GLUFORMIN

Boehringer Mannheim

TAB

500mg

10

6.50

GLYCIPHAGE

Franco-Indian

TAB

500mg

10

6.30

GLYCOMET

USV

TAB

500mg

10

7.25

TAB

250mg

10

4.63

METMIN

Jenburkt

TAB

500mg

10

6.40

WALAPHAGE

Wallace

TAB

500mg

10

7.20

TAB

850mg

10

11.40

TOP

                                                                                                    

 

By |2022-07-20T16:41:38+00:00July 20, 2022|Uncategorized|Comments Off on Metformin

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