Drug Information

  


  











Pharmacokinetics

 

After oral administration it is readily absorbed form gastrointestinal
tract but larger doses are absorbed incompletely, little drug is
metabolised and it is excreted largely unchanged in urine.

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Indication
& Dosage






Oral


ACUTE LYMPHOBLASTIC LEUKEMIA: Maintenance phase 15mg/m2 once or twice
weekly.

CHRIOCARCINOMA: 15-30mg/day x 5 days at interval of 1-2 weeks, for 3-5
cycles.

BURKITT’S LYMPHOMA: 10-15mg/day x 4-8 days, repeated after 7-10
days. 

MYCOSIS FUNGOIDES: 2.5-10mg/day to induce remission

RHEMATOID ARTHRITIS: 7.5mg weekly




Parenteral


ACUTE LYMPHOBLASTIC LEUKEMIA: 15mg/m2 once or twice weekly.
Alternatively 2.5mg/kg IV every 14 days.

MENINGEAL LEUKEMIA: 12mg/m2(not to exceed 15mg) once or twice weekly
intrathecally. Alternatively 500mg/m2 IV followed by folinic acid
rescue.

CHORIOCARCINOMA; 15-30 mg/m2 IM x 5 days at intervals of 1-2 weeks; 3-5
such cycles.

ADVANACED LYMPHOSARCOMA: 3-30MG/KG OR 90-900MG/M2 IV with folinic acid
resuce.

BURKITT’S LYMPHOMA: 50mg IM  as a single dose or in 2 div. doses
weekly.

PSORIASIS: 10-25mg IM/IV weekly.

NOTE:Monitor blood counts, renal and hepatic functions before, during
& after each course.

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Action

 


Inhibits dihydrofolic acid reductase and therefore interferes with
DNA synthesis and cell replication. Actively multiplying cells such as
malignant cells, bone marrow, foetal cells, buccal and intestinal mucosa
and cells in urinary bladder are more sensitive. In patients with
rheumatoid arthritis, mehtotrexate reduces joint swelling and
tenderness.

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Interactions

  

Folic acid and its
derivatives may decrease the effectiveness of methotrexate, although
they are often used in combination to reduce methotrexate toxicity. The
effects of methotrexate may be enhanced by concurrent administration of
agents which can displace it from protein binding or decrease its renal
excretion, such as aminobenzoic acid, some antibacterials, many
anti-inflammatory agents, diuretics, and phenytoin. Fatal toxicity has
occurred in patients given NSAIDs concurrently with methotrexate. Use
with other hepatotoxic or nephrotoxic agents may increase the risk of
toxicity: an increased incidence of cirrhosis has been reported in
patients receiving methotrexate who have an excessive alcohol intake.

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Adverse
Effect & Precaution




Nausea, vomiting, diarrhoea, anaphylaxis, hepatic necrosis, fever, bone
marrow depression, osteoporosis, menstrual dysfunction, cirrhosis,
pulmonary infiltrates and fibrosis, renal toxicity, depigmetation.



Precaution: Children, GI disorders, CNS disturbance, hepatic or renal
impairmet, bone marrow depression. Monitor hepatic, renal and
haematological.

Pregnancy: Contraindicated.

Breast Feeding: Use with caution.

Man: Use with caution.

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Brand
available in market



































BIOTREXATE

Biochem
INJ 5mg Vial 23.14
INJ 15mg Vial 40.25
INJ 50mg Vial 56.35
TAB 2.5mg 10 42.26
CYTOTREX

BDH
TAB 2.5mg 10 31.50
METHOTREXATE-VHB

VHB
INJ 15mg/3ml Vial 47.50
INJ 50mg/2ml Vial 60.00
TAB 2.5mg 10 350.00
MTX-KOREA

Shree Ganesh
TAB 2.5mg 100 350.00
VIAL 500mg/2ml 2ml 102.00
NEOTREXATE

Biddle Sawyer
TAB 2.5mg 10 38.00
ONCOTREX

Sun Pharma
TAB 2.5mg 10 33.00
INJ 50mg 5ml 49.50
ONOTREX

T.D.P.L
TAB 2.5mg 10 24.00
INJ 50mg 5ml 49.50
TEVATREX

SPPL
INJ 50mg/2ml 1 Vial 76.96
TRIXILEM

Elder
TAB 2.5mg 10 16.00
INJ 50mg/ml 2ml 93.65
ZEXATE

Dabur
INJ 25mg/ml 2ml 60.50
INJ 5m/ml 3ml 48.00




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Drug Information
  

  

Pharmacokinetics
 
After oral administration it is readily absorbed form gastrointestinal tract but larger doses are absorbed incompletely, little drug is metabolised and it is excreted largely unchanged in urine.

TOP
     

Indication & Dosage

Oral
ACUTE LYMPHOBLASTIC LEUKEMIA: Maintenance phase 15mg/m2 once or twice weekly.
CHRIOCARCINOMA: 15-30mg/day x 5 days at interval of 1-2 weeks, for 3-5 cycles.
BURKITT’S LYMPHOMA: 10-15mg/day x 4-8 days, repeated after 7-10 days. 
MYCOSIS FUNGOIDES: 2.5-10mg/day to induce remission
RHEMATOID ARTHRITIS: 7.5mg weekly

Parenteral
ACUTE LYMPHOBLASTIC LEUKEMIA: 15mg/m2 once or twice weekly. Alternatively 2.5mg/kg IV every 14 days.
MENINGEAL LEUKEMIA: 12mg/m2(not to exceed 15mg) once or twice weekly intrathecally. Alternatively 500mg/m2 IV followed by folinic acid rescue.
CHORIOCARCINOMA; 15-30 mg/m2 IM x 5 days at intervals of 1-2 weeks; 3-5 such cycles.
ADVANACED LYMPHOSARCOMA: 3-30MG/KG OR 90-900MG/M2 IV with folinic acid resuce.
BURKITT’S LYMPHOMA: 50mg IM  as a single dose or in 2 div. doses weekly.
PSORIASIS: 10-25mg IM/IV weekly.
NOTE:Monitor blood counts, renal and hepatic functions before, during & after each course.

TOP
   

Action
 

Inhibits dihydrofolic acid reductase and therefore interferes with DNA synthesis and cell replication. Actively multiplying cells such as malignant cells, bone marrow, foetal cells, buccal and intestinal mucosa and cells in urinary bladder are more sensitive. In patients with rheumatoid arthritis, mehtotrexate reduces joint swelling and tenderness.

TOP
   

Interactions
  
Folic acid and its derivatives may decrease the effectiveness of methotrexate, although they are often used in combination to reduce methotrexate toxicity. The effects of methotrexate may be enhanced by concurrent administration of agents which can displace it from protein binding or decrease its renal excretion, such as aminobenzoic acid, some antibacterials, many anti-inflammatory agents, diuretics, and phenytoin. Fatal toxicity has occurred in patients given NSAIDs concurrently with methotrexate. Use with other hepatotoxic or nephrotoxic agents may increase the risk of toxicity: an increased incidence of cirrhosis has been reported in patients receiving methotrexate who have an excessive alcohol intake.

TOP
  

Adverse Effect & Precaution

Nausea, vomiting, diarrhoea, anaphylaxis, hepatic necrosis, fever, bone marrow depression, osteoporosis, menstrual dysfunction, cirrhosis, pulmonary infiltrates and fibrosis, renal toxicity, depigmetation.

Precaution: Children, GI disorders, CNS disturbance, hepatic or renal impairmet, bone marrow depression. Monitor hepatic, renal and haematological.
Pregnancy: Contraindicated.
Breast Feeding: Use with caution.
Man: Use with caution.

TOP
   

BIOTREXATE

Biochem

INJ

5mg

Vial

23.14

INJ

15mg

Vial

40.25

INJ

50mg

Vial

56.35

TAB

2.5mg

10

42.26

CYTOTREX

BDH

TAB

2.5mg

10

31.50

METHOTREXATE-VHB

VHB

INJ

15mg/3ml

Vial

47.50

INJ

50mg/2ml

Vial

60.00

TAB

2.5mg

10

350.00

MTX-KOREA

Shree Ganesh

TAB

2.5mg

100

350.00

VIAL

500mg/2ml

2ml

102.00

NEOTREXATE

Biddle Sawyer

TAB

2.5mg

10

38.00

ONCOTREX

Sun Pharma

TAB

2.5mg

10

33.00

INJ

50mg

5ml

49.50

ONOTREX

T.D.P.L

TAB

2.5mg

10

24.00

INJ

50mg

5ml

49.50

TEVATREX

SPPL

INJ

50mg/2ml

1 Vial

76.96

TRIXILEM

Elder

TAB

2.5mg

10

16.00

INJ

50mg/ml

2ml

93.65

ZEXATE

Dabur

INJ

25mg/ml

2ml

60.50

INJ

5m/ml

3ml

48.00

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By |2022-07-20T16:41:38+00:00July 20, 2022|Uncategorized|Comments Off on Methotrexate

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