Drug Information

 


    











Pharmacokinetics

 


When taken by mouth
methoxsalen is well but variably absorbed from the gastrointestinal
tract and there is considerable interindividual variation in peak serum
concentrations. Depending on the oral formulation used increased
photosensitivity is present 1 hour after a dose, reaches a peak at about
1 to 4 hours, and disappears after about 8 hours. Methoxsalen is highly
protein bound. It appears to be preferentially taken up by epidermal
cells. It also diffuses into the lens of the eye. Methoxsalen is almost
completely metabolised. Approximately 95% of a dose is excreted in the
urine within 24 hours. Photosensitivity after topical application may
persist for several days, reaching a peak after about 2 days.

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Indication
& Dosage


 




Oral


VITILIGO: 200mg with food or milk followed 2-4 hrs later by exposure to
sunlight or UVA. Threatment given 2 or 3 times a wee kwith 48 hrs
intervals. Max single dose is 600mcg/kg

PSORIASIS MCOSIS FUNGOIDES:  20mg with food or milk for patinets
between 30-115kg. Patients under 10kg: 10mg; over 115kg-70mg. High
intensity UVA is used/




Topical Skin


Upto 1% formulations applied over lesions before exposure to UVA as
before. Wash off after exposure and protect from light for 12-48 hrs.

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Action

 


Methosalen acts as a photosensitiser. It reaches the skin via the
blood. SUbsequent exposure to Ultra Violet ray 300-400nm wavelength(UVA)
causes cell damage. Inflammation occurs and is follwed by increased
melanisation. In psoriasisphotodamage occurs to DNA and cell
proliferation is reduced. Similar results are see when methosalen is
applied topically with subsequent exposure to UVA.

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Interactions



UV light & overexposure to sunlight: May result in severe burns.
drugs known to cause photosensitisation- Griseofulvin, phenothiazines,
nalidixic acid, halogenated salicylanilides tetracy-clines, thiazides:
Special care should be excercised in treating patients who are taking
these durgs.

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Adverse
Effect & Precaution


 

Photoallergic reactions, blistering, phototoxic eruptions, GI upset,
nausea, insomnia, headache, dizziness psychological depression, leg
cramps, malaise.



Precaution: Eye and lip protection 24 hours post administration. OVer
exposure to sunlight, artificial UV emission. Do not sunbathe during the
24 hours prior to methoxsalen ingestion and UV exposure.

Pregnancy: Contraindicated.

Breast Feeding: Contraindicated.

Man: May be used.

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Brand
available in market


 















MACSORALEN

Mac

TAB

10mg

10

9.50

SOLN

1%

15ml

18.50

MELEDERM

Inga

TAB

10mg

10

8.75

MELANOCYL

Franco-Indian

TABS

10mg

40

28.00

TABS

10mg

200

174.00

SOLN

0.75% w/v

25ml

23.16




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Drug Information
 

    

Pharmacokinetics
 

When taken by mouth methoxsalen is well but variably absorbed from the gastrointestinal tract and there is considerable interindividual variation in peak serum concentrations. Depending on the oral formulation used increased photosensitivity is present 1 hour after a dose, reaches a peak at about 1 to 4 hours, and disappears after about 8 hours. Methoxsalen is highly protein bound. It appears to be preferentially taken up by epidermal cells. It also diffuses into the lens of the eye. Methoxsalen is almost completely metabolised. Approximately 95% of a dose is excreted in the urine within 24 hours. Photosensitivity after topical application may persist for several days, reaching a peak after about 2 days.

TOP
  

Indication & Dosage
 

Oral
VITILIGO: 200mg with food or milk followed 2-4 hrs later by exposure to sunlight or UVA. Threatment given 2 or 3 times a wee kwith 48 hrs intervals. Max single dose is 600mcg/kg
PSORIASIS MCOSIS FUNGOIDES:  20mg with food or milk for patinets between 30-115kg. Patients under 10kg: 10mg; over 115kg-70mg. High intensity UVA is used/

Topical Skin
Upto 1% formulations applied over lesions before exposure to UVA as before. Wash off after exposure and protect from light for 12-48 hrs.

TOP
   

Action
 

Methosalen acts as a photosensitiser. It reaches the skin via the blood. SUbsequent exposure to Ultra Violet ray 300-400nm wavelength(UVA) causes cell damage. Inflammation occurs and is follwed by increased melanisation. In psoriasisphotodamage occurs to DNA and cell proliferation is reduced. Similar results are see when methosalen is applied topically with subsequent exposure to UVA.

TOP
   

Interactions

UV light & overexposure to sunlight: May result in severe burns. drugs known to cause photosensitisation- Griseofulvin, phenothiazines, nalidixic acid, halogenated salicylanilides tetracy-clines, thiazides: Special care should be excercised in treating patients who are taking these durgs.

TOP

 

Adverse Effect & Precaution
 
Photoallergic reactions, blistering, phototoxic eruptions, GI upset, nausea, insomnia, headache, dizziness psychological depression, leg cramps, malaise.

Precaution: Eye and lip protection 24 hours post administration. OVer exposure to sunlight, artificial UV emission. Do not sunbathe during the 24 hours prior to methoxsalen ingestion and UV exposure.
Pregnancy: Contraindicated.
Breast Feeding: Contraindicated.
Man: May be used.

TOP
 

MACSORALEN

Mac

TAB

10mg

10

9.50

SOLN

1%

15ml

18.50

MELEDERM

Inga

TAB

10mg

10

8.75

MELANOCYL

Franco-Indian

TABS

10mg

40

28.00

TABS

10mg

200

174.00

SOLN

0.75% w/v

25ml

23.16

TOP
 
 

 

By |2022-07-20T16:43:07+00:00July 20, 2022|Uncategorized|Comments Off on Methoxsalen Ammoidin

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