Drug Information

 


   











Pharmacokinetics

 

After oral administration bioavailability is low because of extensive
metabolism.

TOP


    

Indication
& Dosage






Oral

HYPERTENSION OF ALL GRADES, HYPERTENSION ASSOCIATED WITH DIABETES AND
PREGANANCY, CHILDREN AND ADOLESCENTS:
250mg 2-3 times a day. After 48
hrs dose changes every 48 hrs until optimum response is obtained.
Maintenance usually 250-500mg b.i.d. Daily max 3g. Children: 10mg/kg/day
in 2-4 divided doses.

TOP


   

Action

 


Methyldopa is metabolised in cnetral noradrenergic neurones to
alphamethyl NA. This is a specific agonist for alpha2 receptors,
sympathetic tone is reduced as is blood pressure.

TOP


  

Interactions

 

Haloperidol: adverse mental symptoms and high incidence of sedation.

Levodopa: Effects of levodopa potentiated.

Corticosteroids & Carbenoxolone: ANtagonism of hypotensive effects.

Propranolol: Paradoxical hypertensive effect.

Diuretics: Enhaced hypotensive effect.

Nitrates: Enhaced hypotensive effect.

Sympathomimetics: Methyldopa potentiates the pressor effects.

Antipsychotics: Increased risk of extrapyramidal symptoms.

Tolbutamide: Hypoglycaemic effects enhanced.

Sex hormones: Antagonise hypotensive effects.

Lab test: Interferes with tests for urinary uric acid by phosphotung-
state method. Serum creatinine by alkaline picrate method.

AST high levels of urinary catecholamines occur interfering with
diagnosis of pheochromocytoma.

TOP


   

Adverse
Effect & Precaution


 

Dizziness, postural hypotension, sedation, dry mouth, headache, sleep
disturbance, depression, anxiety, impotence, blurred vision,
constipation, skin rash, arthralgia, fatigue, anorexia, haemolytic
anemia, Parkinsonian signs, drug fever, hepatitis,



Precaution: Renal dysfunction, acquired haemolytic anemia, patients may
show +ve direct Coomb’s test.

Pregnancy: may be used.

Breast Feeding: May be used.

Man: May be used with caution.

TOP


 

Brand
available in market


 














ALPHADOPA

Merind

TAB

250mg

10

22.10

DOPAGYT

Themis Pharma

TAB

250mg

10

15.29

EMDOPA

IDPL

TAB

250mg

10

30.48

SEMBRINA

Boehringer Mannheim

TAB

250mg

10

24.14




TOP






 

 






 

 

 

 
Drug Information
 

   

Pharmacokinetics
 
After oral administration bioavailability is low because of extensive metabolism.

TOP
    

Indication & Dosage

Oral
HYPERTENSION OF ALL GRADES, HYPERTENSION ASSOCIATED WITH DIABETES AND PREGANANCY, CHILDREN AND ADOLESCENTS:
250mg 2-3 times a day. After 48 hrs dose changes every 48 hrs until optimum response is obtained. Maintenance usually 250-500mg b.i.d. Daily max 3g. Children: 10mg/kg/day in 2-4 divided doses.

TOP
   

Action
 

Methyldopa is metabolised in cnetral noradrenergic neurones to alphamethyl NA. This is a specific agonist for alpha2 receptors, sympathetic tone is reduced as is blood pressure.

TOP
  

Interactions
 
Haloperidol: adverse mental symptoms and high incidence of sedation.
Levodopa: Effects of levodopa potentiated.
Corticosteroids & Carbenoxolone: ANtagonism of hypotensive effects.
Propranolol: Paradoxical hypertensive effect.
Diuretics: Enhaced hypotensive effect.
Nitrates: Enhaced hypotensive effect.
Sympathomimetics: Methyldopa potentiates the pressor effects.
Antipsychotics: Increased risk of extrapyramidal symptoms.
Tolbutamide: Hypoglycaemic effects enhanced.
Sex hormones: Antagonise hypotensive effects.
Lab test: Interferes with tests for urinary uric acid by phosphotung- state method. Serum creatinine by alkaline picrate method.
AST high levels of urinary catecholamines occur interfering with diagnosis of pheochromocytoma.

TOP
   

Adverse Effect & Precaution
 
Dizziness, postural hypotension, sedation, dry mouth, headache, sleep disturbance, depression, anxiety, impotence, blurred vision, constipation, skin rash, arthralgia, fatigue, anorexia, haemolytic anemia, Parkinsonian signs, drug fever, hepatitis,

Precaution: Renal dysfunction, acquired haemolytic anemia, patients may show +ve direct Coomb’s test.
Pregnancy: may be used.
Breast Feeding: May be used.
Man: May be used with caution.

TOP
 

ALPHADOPA

Merind

TAB

250mg

10

22.10

DOPAGYT

Themis Pharma

TAB

250mg

10

15.29

EMDOPA

IDPL

TAB

250mg

10

30.48

SEMBRINA

Boehringer Mannheim

TAB

250mg

10

24.14

TOP

 
 

 

By |2022-07-20T16:44:59+00:00July 20, 2022|Uncategorized|Comments Off on Methyldopa

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