Methylergometrine

Pharmacokinetics

 

Methylergometrine maleate is reported to be rapidly absorbed after
administration by mouth and by intramuscular injection. It undergoes
extensive first-pass hepatic metabolism. It is mainly excreted in the
urine as metabolites.

The pharmacokinetics of methylergometrine maleate has been studied
following oral administration in healthy subjects (1) and in postpartum
women. (2) Small amounts of methylergometrine have been detected in
breast milk.

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Indication
& Dosage





IM/IV

UNDER FULL OBSTETRIC SUPERVISION TO SHORTEN THIRD STAGE OF LABOR
FOLLOWING DELIVERY OF ANTERIOR SHOULDER; ROUTINE MANAGEMENT AFTER
DELIVERY OF PLACENTA; POSTPARTUM OR POSTABORTAL ATONY & HEMORRHAGE:
0.2MG IM; may be repeated as reqd. at intervals of 2-4 hrs. IV use is
not routinely advocated unless as an emergency measure. IV dose same as
IM dose.

Oral


MILD POSTPARTUM HEMORRHAGE; UTERINE SUBINVOLUTION: 0.2mg t.i.d/q.i.d. in
the puerperuim for a maximum of one week.

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Action

 

An ergot alkaloid, it causes contraction of uterine smooth muscle
with an increase in contraction frequency & amplitude at low doses
& elevation of uterine tone at higher doses. Mechanism involves
stimulation of uterine smooth muscle through alpha-receptors. High doses
cause sustained uterine contraction with elevation of basal tone. Blood
flow through the spiral arteries is decreased by contraction of the
myometrium; drug also causes constriction of vascular smooth muscle,
affecting mainly capacitance vessels. Prolonged use can produce sign of
ergotism.

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Interactions

Precaution

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Brand
available in market