Drug Information

 


  











Pharmacokinetics

 


Methylergometrine maleate is reported to be rapidly absorbed after
administration by mouth and by intramuscular injection. It undergoes
extensive first-pass hepatic metabolism. It is mainly excreted in the
urine as metabolites.


The pharmacokinetics of methylergometrine maleate has been studied
following oral administration in healthy subjects (1) and in postpartum
women. (2) Small amounts of methylergometrine have been detected in
breast milk.

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Indication
& Dosage






IM/IV

UNDER FULL OBSTETRIC SUPERVISION TO SHORTEN THIRD STAGE OF LABOR
FOLLOWING DELIVERY OF ANTERIOR SHOULDER; ROUTINE MANAGEMENT AFTER
DELIVERY OF PLACENTA; POSTPARTUM OR POSTABORTAL ATONY & HEMORRHAGE:

0.2MG IM; may be repeated as reqd. at intervals of 2-4 hrs. IV use is
not routinely advocated unless as an emergency measure. IV dose same as
IM dose.

Oral


MILD POSTPARTUM HEMORRHAGE; UTERINE SUBINVOLUTION
: 0.2mg t.i.d/q.i.d. in
the puerperuim for a maximum of one week.

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Action

 


An ergot alkaloid, it causes contraction of uterine smooth muscle
with an increase in contraction frequency & amplitude at low doses
& elevation of uterine tone at higher doses. Mechanism involves
stimulation of uterine smooth muscle through alpha-receptors. High doses
cause sustained uterine contraction with elevation of basal tone. Blood
flow through the spiral arteries is decreased by contraction of the
myometrium; drug also causes constriction of vascular smooth muscle,
affecting mainly capacitance vessels. Prolonged use can produce sign of
ergotism.

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Interactions

Precaution

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Brand
available in market


 

































ERGOMET

M.M. Labs

INJ

0.2mg/ml

10x1ml

50.00

TABS

0.125mg

10

19.25

GOTRIN

Rekvina Labs

TAB

0.2mg/ml

10

28.00

INJ

0.125mg

1ml

6.50

HICON

Systopic

TAB

0.125mg

10

28.25

INGAGEN-M

Inga

INJ

0.2mg/ml

1ml

9.00

TAB

0.125mg

10

30.00

LERIN

Troikaa

TAB

0.2mg/ml

10

33.00

INJ

0.125mg

1ml

8.00

MEM

Neon Labs

INJ

0.2mg/ml

10amp

108.00

MERGOX

BPL Pharma

TAB

0.2mg/ml

10

200.00

INJ

0.125mg

1ml amp

200.00

METHERGIN

Novartis

TAB

0.2mg/ml

10

38.85

INJ

0.125mg

5amps

60.90

METHERONE

Mejda

INJ

0.2mg/ml

50ml

230.67

UTERGIN

Sigma

INJ

0.2mg/ml

50x1ml

302.50

TAB

0.125mg

10×12

340.80



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Drug Information
 

  

Pharmacokinetics
 

Methylergometrine maleate is reported to be rapidly absorbed after administration by mouth and by intramuscular injection. It undergoes extensive first-pass hepatic metabolism. It is mainly excreted in the urine as metabolites.

The pharmacokinetics of methylergometrine maleate has been studied following oral administration in healthy subjects (1) and in postpartum women. (2) Small amounts of methylergometrine have been detected in breast milk.

TOP
  

Indication & Dosage

IM/IV
UNDER FULL OBSTETRIC SUPERVISION TO SHORTEN THIRD STAGE OF LABOR FOLLOWING DELIVERY OF ANTERIOR SHOULDER; ROUTINE MANAGEMENT AFTER DELIVERY OF PLACENTA; POSTPARTUM OR POSTABORTAL ATONY & HEMORRHAGE:
0.2MG IM; may be repeated as reqd. at intervals of 2-4 hrs. IV use is not routinely advocated unless as an emergency measure. IV dose same as IM dose.
Oral
MILD POSTPARTUM HEMORRHAGE; UTERINE SUBINVOLUTION: 0.2mg t.i.d/q.i.d. in the puerperuim for a maximum of one week.

TOP
   

Action
 

An ergot alkaloid, it causes contraction of uterine smooth muscle with an increase in contraction frequency & amplitude at low doses & elevation of uterine tone at higher doses. Mechanism involves stimulation of uterine smooth muscle through alpha-receptors. High doses cause sustained uterine contraction with elevation of basal tone. Blood flow through the spiral arteries is decreased by contraction of the myometrium; drug also causes constriction of vascular smooth muscle, affecting mainly capacitance vessels. Prolonged use can produce sign of ergotism.

TOP
   

ERGOMET

M.M. Labs

INJ

0.2mg/ml

10x1ml

50.00

TABS

0.125mg

10

19.25

GOTRIN

Rekvina Labs

TAB

0.2mg/ml

10

28.00

INJ

0.125mg

1ml

6.50

HICON

Systopic

TAB

0.125mg

10

28.25

INGAGEN-M

Inga

INJ

0.2mg/ml

1ml

9.00

TAB

0.125mg

10

30.00

LERIN

Troikaa

TAB

0.2mg/ml

10

33.00

INJ

0.125mg

1ml

8.00

MEM

Neon Labs

INJ

0.2mg/ml

10amp

108.00

MERGOX

BPL Pharma

TAB

0.2mg/ml

10

200.00

INJ

0.125mg

1ml amp

200.00

METHERGIN

Novartis

TAB

0.2mg/ml

10

38.85

INJ

0.125mg

5amps

60.90

METHERONE

Mejda

INJ

0.2mg/ml

50ml

230.67

UTERGIN

Sigma

INJ

0.2mg/ml

50x1ml

302.50

TAB

0.125mg

10×12

340.80

TOP
 
 

 

By |2022-07-20T16:42:54+00:00July 20, 2022|Uncategorized|Comments Off on Methylergometrine

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