Drug Information

  


   





Metoprolol



         

Pharmacokinetics
| Indication
& Dosage
| Action
| Interacations | 
Precautions
|
 


           












Pharmacokinetics  

It is well absorbed after oral administration,
extensively metabolised in the liver with little unchanged drug
appearing in the urine. Its bio-availablity is 50%.    

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Indication
& Dosage




 



Oral

HYPERTENSION, ANGINA, FUNCTIONAL CARDIAC DISORDERS, HYPERTHYROIDISM:
100mg daily. May be increased by 100mg at weekly interval upto 200mg
b.i.d.

IV

SUPRAVENTRICULAR TACHYCARDIA: Intially 5mg at 1-2mg/min. May be repeated
at intervals of 5mins. Usually a total dose of 10-15mg is adequate.
Continue with oral therapy starting 4-6h after the last injection at
50mg t.i.d. 

ACUTE MI: 5mg IV every 2mins upto max of 15mg. Oral therapy 15min later
50mg 6 hrly for 48 hrs.

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Action

 


Inhibition of beta-1 receptors by metoprolol results in reduced
heart rate and lowered blood pressure. Cardiac output is reduced. Renin
release is bronchoconstriction.

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Interactions

It may increase the risk of serious allergic reaction
to these drugs: Aminophylline, Caffeine, Deriphylline, Oxtriphylline or
Theophylline : the effects of both these drugs and beta-blockers may be
blocked; in addition, theophylline levels in the body may be increased,
especially in patients who smoke. Oral Antidiabetics or Insulin: There
is an increased risk of hyperglycemia ; beta-blockers may cover up
certain symptoms of hypoglycemia such as increases in pulse rate and
hypertension, and may prolong the hypoglycemia. Calcium channel blockers
(bepridil, diltiazem, felodipine, isradipine, nicardipine, nifedipine,
nimodipine, verapamil ) : Effects on blood pressure may be increased.
Cardiac arrhythmias may occur when beta-blockers are used with calcium
channel blockers. Cocaine: Cocaine may block the effects of
beta-blockers; in addition, there is an increased risk of hypertension,
tachycardia, and possibly cardiac arrhythmias if cocaine is used while
taking a beta-blocker. With Monoamine oxidase (MAO) inhibitors: Taking
beta-blockers within 2 weeks of taking monoamine oxidase (MAO)
inhibitors may cause severe hypertension.


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Adverse
Effect & Precaution




Headache, dizziness, nausea,
vomiting, skin rash, diarrhoea, nightmares, hypotension, bradycardia.


Allergies : Allergic reaction to the beta-blocker may
occur. Pregnancy : Use of beta-blockers during pregnancy has been
associated with hypoglycaemia, dyspnoea, bradycardia, hypotension in the
new born infant. Breast-feeding : Atenolol may pass into breast milk.
Problems such as dyspnoea, bradycardia, hypotension have been reported
in nursing babies. Adults : Some side effects are more likely to occur
in the elderly, who are usually more sensitive to the effects of
beta-blockers. Also, beta-blockers may reduce tolerance to cold
temperatures in elderly patients.

Pregnancy: Use with Caution.

Breast Feeding: Use with Caution.

Man: May be used.



                                                                      
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Brand
available in market


  



















BETALOC

Astra-IDL
INJ 1mg/ml 5x5ml 24.30
TAB 50mg 10 15.00
TAB 100mg 10 25.25
LOPRESOR

Novartis
TAB 50mg 10×10 147.00
TAB 100mg 10×10 250.00
METOCARD

Torrent
TAB 50mg 10 7.80
TAB 100mg 10 14.80
METOLAR

Cipla
TAB 50mg 10 13.50
TAB 100mg 10 24.00
INJ 1mg/ml 5ml 4.63






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Drug Information
  

   

Metoprolol
         

Pharmacokinetics  

It is well absorbed after oral administration, extensively metabolised in the liver with little unchanged drug appearing in the urine. Its bio-availablity is 50%.    

Top
    

Indication & Dosage
 
Oral
HYPERTENSION, ANGINA, FUNCTIONAL CARDIAC DISORDERS, HYPERTHYROIDISM: 100mg daily. May be increased by 100mg at weekly interval upto 200mg b.i.d.

IV
SUPRAVENTRICULAR TACHYCARDIA: Intially 5mg at 1-2mg/min. May be repeated at intervals of 5mins. Usually a total dose of 10-15mg is adequate. Continue with oral therapy starting 4-6h after the last injection at 50mg t.i.d. 
ACUTE MI: 5mg IV every 2mins upto max of 15mg. Oral therapy 15min later 50mg 6 hrly for 48 hrs.

Top
     

Action
 

Inhibition of beta-1 receptors by metoprolol results in reduced heart rate and lowered blood pressure. Cardiac output is reduced. Renin release is bronchoconstriction.

Top
   

Interactions

It may increase the risk of serious allergic reaction to these drugs: Aminophylline, Caffeine, Deriphylline, Oxtriphylline or Theophylline : the effects of both these drugs and beta-blockers may be blocked; in addition, theophylline levels in the body may be increased, especially in patients who smoke. Oral Antidiabetics or Insulin: There is an increased risk of hyperglycemia ; beta-blockers may cover up certain symptoms of hypoglycemia such as increases in pulse rate and hypertension, and may prolong the hypoglycemia. Calcium channel blockers (bepridil, diltiazem, felodipine, isradipine, nicardipine, nifedipine, nimodipine, verapamil ) : Effects on blood pressure may be increased. Cardiac arrhythmias may occur when beta-blockers are used with calcium channel blockers. Cocaine: Cocaine may block the effects of beta-blockers; in addition, there is an increased risk of hypertension, tachycardia, and possibly cardiac arrhythmias if cocaine is used while taking a beta-blocker. With Monoamine oxidase (MAO) inhibitors: Taking beta-blockers within 2 weeks of taking monoamine oxidase (MAO) inhibitors may cause severe hypertension.

Top
 

Adverse Effect & Precaution

Headache, dizziness, nausea, vomiting, skin rash, diarrhoea, nightmares, hypotension, bradycardia.

Allergies : Allergic reaction to the beta-blocker may occur. Pregnancy : Use of beta-blockers during pregnancy has been associated with hypoglycaemia, dyspnoea, bradycardia, hypotension in the new born infant. Breast-feeding : Atenolol may pass into breast milk. Problems such as dyspnoea, bradycardia, hypotension have been reported in nursing babies. Adults : Some side effects are more likely to occur in the elderly, who are usually more sensitive to the effects of beta-blockers. Also, beta-blockers may reduce tolerance to cold temperatures in elderly patients.
Pregnancy: Use with Caution.
Breast Feeding: Use with Caution.
Man: May be used.

                                                                       Top
               

BETALOC

Astra-IDL

INJ

1mg/ml

5x5ml

24.30

TAB

50mg

10

15.00

TAB

100mg

10

25.25

LOPRESOR

Novartis

TAB

50mg

10×10

147.00

TAB

100mg

10×10

250.00

METOCARD

Torrent

TAB

50mg

10

7.80

TAB

100mg

10

14.80

METOLAR

Cipla

TAB

50mg

10

13.50

TAB

100mg

10

24.00

INJ

1mg/ml

5ml

4.63

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By |2022-07-20T16:44:59+00:00July 20, 2022|Uncategorized|Comments Off on Metoprolol

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