Drug Information

 


  












  


Pharmacokinetics

 


About 90% of an oral dose of minoxidil has been reported to be absorbed
from the gastrointestinal tract. The plasma half-life is about 4.2 hours
although the haemodynamic effect may persist for up to 75 hours,
presumably due to accumulation at its site of action. Minoxidil is not
bound to plasma proteins. It is distributed into breast milk. Minoxidil
is extensively metabolised by the liver. It requires sulphation to
become active, but the major metabolite is a glucuronide conjugate.
Minoxidil is excreted predominantly in the urine mainly in the form of
metabolites. Minoxidil and its metabolites are dialysable.

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Indication
& Dosage


 



Topical

MALE PATTERN BALDNESS:
2% w/v solution. 1ml applied to baid area
twice daily.

 
Action

 


Orginally developed for hypertension because of its direct
vasodilating property. Reduces elevated BP with reflex tachycardia, 
increased cardiac output and elevated plasm renin. Applied topically
minoxidil corrects male pattern baldness. This is not because of any
hormone effects and is probably due to increased skin blood flow.

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Interactions

 


The antihypertensive effect of minoxidil may be enhanced by concomitant
use of other hypotensive drugs. Severe orthostatic hypotension may occur
if minoxidil and sympathetic blocking drugs such as guanethidine or
bethanidine are given concurrently.

Topical minoxidil should not be used with other topical agents known to
enhance absorption, such as corticosteroids, retinoids, or occlusive
ointment bases.

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Adverse
Effect & Precaution




Chest pain, dizziness, headache, dematitis, changes in blood pressure
and pulse, oedema.



Precaution: Avoid contact with eyes, broken skin, hypotension. To be
applied on scalponly.

Pregnancy: Contraindicated.

Breast Feeding: Contraindicated.

Man: Safety above 65 years not established.

 

Brand
available in market
















GROMANE

Alidac
SOLN 20mg/ml 60ml 150.00
HAIREX

Kopran
SOLN 2% w/v 60ml 201.25
HYGAINE

Dabur
SOLN 20mg/ml 60ml 131.00
MINTOP

DR.Reddy’s
SOLN 2% 60ml 132.85
MULTIGANI

Torrent
CREAM 2% 60ml 163.25




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Drug Information
 

  

  
Pharmacokinetics
 

About 90% of an oral dose of minoxidil has been reported to be absorbed from the gastrointestinal tract. The plasma half-life is about 4.2 hours although the haemodynamic effect may persist for up to 75 hours, presumably due to accumulation at its site of action. Minoxidil is not bound to plasma proteins. It is distributed into breast milk. Minoxidil is extensively metabolised by the liver. It requires sulphation to become active, but the major metabolite is a glucuronide conjugate. Minoxidil is excreted predominantly in the urine mainly in the form of metabolites. Minoxidil and its metabolites are dialysable.

TOP
       

Indication & Dosage
 

Topical
MALE PATTERN BALDNESS:
2% w/v solution. 1ml applied to baid area twice daily.
 

Action
 

Orginally developed for hypertension because of its direct vasodilating property. Reduces elevated BP with reflex tachycardia,  increased cardiac output and elevated plasm renin. Applied topically minoxidil corrects male pattern baldness. This is not because of any hormone effects and is probably due to increased skin blood flow.

TOP
    

Interactions
 

The antihypertensive effect of minoxidil may be enhanced by concomitant use of other hypotensive drugs. Severe orthostatic hypotension may occur if minoxidil and sympathetic blocking drugs such as guanethidine or bethanidine are given concurrently.
Topical minoxidil should not be used with other topical agents known to enhance absorption, such as corticosteroids, retinoids, or occlusive ointment bases.

TOP
   

Adverse Effect & Precaution

Chest pain, dizziness, headache, dematitis, changes in blood pressure and pulse, oedema.

Precaution: Avoid contact with eyes, broken skin, hypotension. To be applied on scalponly.
Pregnancy: Contraindicated.
Breast Feeding: Contraindicated.
Man: Safety above 65 years not established.
 

GROMANE

Alidac

SOLN

20mg/ml

60ml

150.00

HAIREX

Kopran

SOLN

2% w/v

60ml

201.25

HYGAINE

Dabur

SOLN

20mg/ml

60ml

131.00

MINTOP

DR.Reddy’s

SOLN

2%

60ml

132.85

MULTIGANI

Torrent

CREAM

2%

60ml

163.25

TOP
 
 

 

By |2022-07-20T16:43:07+00:00July 20, 2022|Uncategorized|Comments Off on Minoxidil

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