Drug Information

   


  










Pharmacokinetics



It shows first bypass effect and therefore its oral bioavailability is
low. It also crosses placental barrier.

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Indication
& Dosage



  


Oral

SEVERE PAIN & INTRACTABLE PAIN OF CANCER:
10-50mg every 4hrs.

Children: 5-10mg.

Cont. rel. Usually 30-60mg every 12 hrs; further increments of 25-50% if
necessary. In palliative cancer care, 10-20mg b.i.d to start with is
preferred with gradual increments.

Parenteral

ACUTE INTRACTABLE PAIN:
10mg SC/IM every 4hrs (if reqd). Children less
than 1mth: 0.15mg/kg. 1-12mths: 0.2mg/kg. 1-5yrs: 2.5-5mg. 6-12yrs:
5-10mg

IV dose is quarter to half corresponding IM dose.

M.I, ACUTE PULMONARY OEDEMA: Slow IV inj (2mg/min) of 10mg followed by
5-10mg if reqd; in elderly and debilitated reduce by half.

CHRONIC PAIN: SC/IM 5-20MG EVERY 4hrs as reqd.

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Action

 


A potent analgesic with stimulant effect at the mu-receptors.
Analgesia, euphoria and dependence are thought to be due to its action
at hte mu-1 receptors while respiratoy depression and inhibitionof
intestinal movements are due to action at the mu-2 receptores. Spinal
analgesia is meiated by morphine agonist action at the K recptor. Cough
is suppressed by direct action on cough centre. Morphine acts on the
hypothalamus and pituitary-adrenal axis and affects releaseof several
hormones. Though it has little significant effects on the CVS postural
hypotension could occur due to the vascular effects of histmaine
released by morphine.

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Adverse
Effect & Precaution




Constipation, confusion, dry mouth, miosis, nausea, vomiting, dysphoria,
fatigue and abdominal distension, skin rash, hypotension and
anphylactoid reaction. Abuse potential. Loss of appetite on chronic use.



Precaution: Contraindicated.

Breast Feeding: Use with caution

Man: May be given in reduced dose.

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Brand
available in market


 












LIQUID RILIMORF

BDH
LIQUID 1% w/v 100ml 60.00
MORCONTIN

Modi Mundi Pharma
CR TAB 10mg 10 30.50
CR TAB 30mg 10 55.00
TAB 60mg 10 99.00
TAB 100mg 10 154.00





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Drug Information
   

  

Pharmacokinetics

It shows first bypass effect and therefore its oral bioavailability is low. It also crosses placental barrier.

TOP
    

Indication & Dosage
  
Oral
SEVERE PAIN & INTRACTABLE PAIN OF CANCER:
10-50mg every 4hrs.
Children: 5-10mg.
Cont. rel. Usually 30-60mg every 12 hrs; further increments of 25-50% if necessary. In palliative cancer care, 10-20mg b.i.d to start with is preferred with gradual increments.

Parenteral
ACUTE INTRACTABLE PAIN:
10mg SC/IM every 4hrs (if reqd). Children less than 1mth: 0.15mg/kg. 1-12mths: 0.2mg/kg. 1-5yrs: 2.5-5mg. 6-12yrs: 5-10mg
IV dose is quarter to half corresponding IM dose.
M.I, ACUTE PULMONARY OEDEMA: Slow IV inj (2mg/min) of 10mg followed by 5-10mg if reqd; in elderly and debilitated reduce by half.
CHRONIC PAIN: SC/IM 5-20MG EVERY 4hrs as reqd.

TOP
   

Action
 

A potent analgesic with stimulant effect at the mu-receptors. Analgesia, euphoria and dependence are thought to be due to its action at hte mu-1 receptors while respiratoy depression and inhibitionof intestinal movements are due to action at the mu-2 receptores. Spinal analgesia is meiated by morphine agonist action at the K recptor. Cough is suppressed by direct action on cough centre. Morphine acts on the hypothalamus and pituitary-adrenal axis and affects releaseof several hormones. Though it has little significant effects on the CVS postural hypotension could occur due to the vascular effects of histmaine released by morphine.

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Adverse Effect & Precaution

Constipation, confusion, dry mouth, miosis, nausea, vomiting, dysphoria, fatigue and abdominal distension, skin rash, hypotension and anphylactoid reaction. Abuse potential. Loss of appetite on chronic use.

Precaution: Contraindicated.
Breast Feeding: Use with caution
Man: May be given in reduced dose.

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LIQUID RILIMORF

BDH

LIQUID

1% w/v

100ml

60.00

MORCONTIN

Modi Mundi Pharma

CR TAB

10mg

10

30.50

CR TAB

30mg

10

55.00

TAB

60mg

10

99.00

TAB

100mg

10

154.00

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By |2022-07-20T16:44:59+00:00July 20, 2022|Uncategorized|Comments Off on Morphine

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