|
Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interacations| Adverse
Effects & Precautions |
Brands available in Market
It is completely absorbed and is distributed throughout the body, it has elimination half life of 11hrs, and is excreted in the urine.
Indication
& Dosage
Oral
INFECTIONS OF RESP. TRACT, URINARY TRACT, GI INFECTIONS UNCLUDING
PERITONITIS , SKIN AND SOFT TISSUSE INFECTIONS, UROGENITAL INFECTIONS:
Adults: 200-800mg/day upto 10 days. Children: Not recommended.
UNCOMPLICATED CONORRHEA;}
40mg single dose.
IV Infusion
SEVERE COMPLICATED INFECTIONS, SEPTICAEMIA: 200mg infusion over 30mins
b.i.d. Maybe increased to 400mg b.i.d. in servere infections
Note: Elderly: Reduction only if renal impairment exists. Renal
impairment dose reduction related to creatinine clearance.
24hrly
Action
One of the most potent fluroquinolones. Susceptible pathogens
include Chlamydia trachomatis, Citrobacter, Enterobacter, E.Coil,
H.influenzae, Klebsiella pneumoniae, Meisseria gonorrhoeae, Proteus
mirabilis, pseudomonas aeruginosa, Staph aureus, Strep. pneumoniae,
Strep. pyogenes. Anaerobes such as Bacteroides spp, Clostridium spp,
Gardnerellla vaginalis, Peptococcus and peptosreptococcus spp are also
susceptible. Ohter sensitive pathogens include legionella, Mycoplasma.
With : Antacids, Iron supplements or Sucralfate :
These may keep Ofloxacin from being effective. Didanosine may reduce the
effectiveness of Ofloxacin.
Adverse Effect &
Precautions
Nausea, epigastric
discomfort, vomiting, Pseudomembranous colitis, skin rash, myalgia,
arthralgia and bone marrow depression.
With Brain or spinal cord disease, including
arterisclerosis in the brain or epilepsy or other seizures :
Fluoroquinolones may cause neurological symptoms, renal impairment and
hepatic disease: Patients with renal disease (alone) or renal disease
and hepatic disease (together) may have an increased chance of side
effects.
Pregnancy: Contraindicated.
Breast Feeding: Contraindicated.
Man: May be use.
