Drug Information

   
  




   











Pharmacokinetics

It is completely absorbed and is distributed
throughout the body, it has elimination half life of 11hrs, and is
excreted in the urine.


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Indication
& Dosage





Oral

INFECTIONS OF RESP. TRACT, URINARY TRACT, GI INFECTIONS UNCLUDING
PERITONITIS , SKIN AND SOFT TISSUSE INFECTIONS, UROGENITAL INFECTIONS:

Adults: 200-800mg/day upto 10 days. Children: Not recommended.

UNCOMPLICATED CONORRHEA;}

40mg single dose.



IV Infusion

SEVERE COMPLICATED INFECTIONS, SEPTICAEMIA: 200mg infusion over 30mins
b.i.d. Maybe increased to 400mg b.i.d. in servere infections

Note: Elderly: Reduction only if renal impairment exists. Renal
impairment dose reduction related to creatinine clearance.





cc(ml/min Dose Interval
10-50 less than 10 No change reduce by 50% 24hrly

24hrly


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Action



One of the most potent fluroquinolones. Susceptible pathogens
include Chlamydia trachomatis, Citrobacter, Enterobacter, E.Coil,
H.influenzae, Klebsiella pneumoniae, Meisseria gonorrhoeae, Proteus
mirabilis, pseudomonas aeruginosa, Staph aureus, Strep. pneumoniae,
Strep. pyogenes. Anaerobes such as Bacteroides spp, Clostridium spp,
Gardnerellla vaginalis, Peptococcus and peptosreptococcus spp are also
susceptible. Ohter sensitive pathogens include legionella, Mycoplasma.

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Interaction

With : Antacids, Iron supplements or Sucralfate :
These may keep Ofloxacin from being effective. Didanosine may reduce the
effectiveness of Ofloxacin.




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Adverse Effect &
Precautions




Nausea, epigastric
discomfort, vomiting, Pseudomembranous colitis, skin rash, myalgia,
arthralgia and bone marrow depression.

With Brain or spinal cord disease, including
arterisclerosis in the brain or epilepsy or other seizures :
Fluoroquinolones may cause neurological symptoms, renal impairment and
hepatic disease: Patients with renal disease (alone) or renal disease
and hepatic disease (together) may have an increased chance of side
effects.

Pregnancy: Contraindicated.

Breast Feeding: Contraindicated.

Man: May be use.

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Brands
available in market


















BESTOFLOX

BESTOCHEM
TABS 100mg 10 95.00
TABS 200mg 10 180.00
INJ 200mg 100ml 84.00
TARIVID

Hoechst Marion Roussel
TAB 200mg 4 104.00
INJ-IV 200mg 100ml 84.00
ZANOCIN

Stancare
TAB 100mg 6 96.00
TAB 200mg 8 248.00
INJ-IV 200mg 100ml 85.25



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Drug Information
   
  

   

Pharmacokinetics

It is completely absorbed and is distributed throughout the body, it has elimination half life of 11hrs, and is excreted in the urine.

TOP
    

Indication & Dosage

Oral
INFECTIONS OF RESP. TRACT, URINARY TRACT, GI INFECTIONS UNCLUDING PERITONITIS , SKIN AND SOFT TISSUSE INFECTIONS, UROGENITAL INFECTIONS:
Adults: 200-800mg/day upto 10 days. Children: Not recommended.
UNCOMPLICATED CONORRHEA;}
40mg single dose.

IV Infusion
SEVERE COMPLICATED INFECTIONS, SEPTICAEMIA: 200mg infusion over 30mins b.i.d. Maybe increased to 400mg b.i.d. in servere infections
Note: Elderly: Reduction only if renal impairment exists. Renal impairment dose reduction related to creatinine clearance.

cc(ml/min

Dose

Interval

10-50 less than 10

No change reduce by 50%

24hrly
24hrly

TOP
    

Action

One of the most potent fluroquinolones. Susceptible pathogens include Chlamydia trachomatis, Citrobacter, Enterobacter, E.Coil, H.influenzae, Klebsiella pneumoniae, Meisseria gonorrhoeae, Proteus mirabilis, pseudomonas aeruginosa, Staph aureus, Strep. pneumoniae, Strep. pyogenes. Anaerobes such as Bacteroides spp, Clostridium spp, Gardnerellla vaginalis, Peptococcus and peptosreptococcus spp are also susceptible. Ohter sensitive pathogens include legionella, Mycoplasma.

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Interaction

With : Antacids, Iron supplements or Sucralfate : These may keep Ofloxacin from being effective. Didanosine may reduce the effectiveness of Ofloxacin.


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Adverse Effect & Precautions

Nausea, epigastric discomfort, vomiting, Pseudomembranous colitis, skin rash, myalgia, arthralgia and bone marrow depression.

With Brain or spinal cord disease, including arterisclerosis in the brain or epilepsy or other seizures : Fluoroquinolones may cause neurological symptoms, renal impairment and hepatic disease: Patients with renal disease (alone) or renal disease and hepatic disease (together) may have an increased chance of side effects.
Pregnancy: Contraindicated.
Breast Feeding: Contraindicated.
Man: May be use.

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BESTOFLOX

BESTOCHEM

TABS

100mg

10

95.00

TABS

200mg

10

180.00

INJ

200mg

100ml

84.00

TARIVID

Hoechst Marion Roussel

TAB

200mg

4

104.00

INJ-IV

200mg

100ml

84.00

ZANOCIN

Stancare

TAB

100mg

6

96.00

TAB

200mg

8

248.00

INJ-IV

200mg

100ml

85.25

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By |2022-07-20T16:43:34+00:00July 20, 2022|Uncategorized|Comments Off on Ofloxacin

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