Drug Information

 


     











Pharmacokinetics

It is a proton pump inhibitor.It is rapidly
absorbed.It supresses the gastric acid secretion by inhibition of
Hydrogen Potassium ATPase and thus blocks the final step in gastric acid
secretion. It causes almost 100% inhibition of gastric acid secretion in
the stomach. It has a plasma 1/2 life of 30-90 min, and duration of
action is 24 hours. It is 98 % bound to plasma proteins. It is
metabolised in liver and excreted mainly in the urine.


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Indication
& Dosage

Oral

DUODENAL ULCER:
20mg/day 4-8 weeks


GASTRIC ULCER:
20mg/day 8 weeks.


REFLUX OESOPHAGITIS:
20mg/day 4-8 days. Omeprazole should preferably be
taken in the morning before food.


ZOLLINGER-ELLISON SYNDROME:
Start at 60mg once daily. Usual range
20-120mg/day(above 80mg in 2 div doses).


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Action


Suppresses gastric acid secretion by specific inhibition of the
enzyme h+k+ ATPase present on the secretory surface of the gastric
parietal cell. This blocks the final and common step in gastric acid
secretion. Both basal and stinulated acid secretions are inhibited
irrespectiveof the stimulus. Peptic activity is reduced. It suppresses
Helicobacter Pylore.


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Interaction

It prolongs the elimination of diazepam, warfarin,
phenytoin and aminophylline.


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Adverse Effect &
Precautions





Nausea, constipation, diarrhoea,
skin rash, headache.

Precautions must be taken when taking the drug during
pregnancy,cirrhosis, malignancy and prolonged use.

Pregnancy: Safety not established.

Breast Feeding: Contraindicated.

Man: May be used.


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Brands
available in market







































































































ACICHEK

Boehringer Mannheim
CAPS 20mg 10 29.75
BIOCID

Biochem
CAPS 20mg 10 37.73
CAPS 10mg 10 20.12
BIOZOLE

Sara Biotech
CAP 20mg 10 36.50
COSZOL

CFL
CAPS 20mg 10 20.00
COSZOL 10

CFL
CAP 10mg 10 20.00
COZEP

SPPL
CAPS 10mg 10 20.05
CAPS 20mg 10 37.27
LOKIT

Kramer
CAPS 20mg 10 34.80
CAPS 10mg 6×10 99.60
LOMAC

Cipla
CAPS 10mg 10 20.50
CAPS 20mg 10 38.00
LORESS

Biological E
CAPS 10mg 10 19.58
CAPS 20mg 10 38.00
LOSEC

Emcure
CAPS 10mg 10 20.00
CAPS 20mg 10 39.00
MENZOL-20

Menarini Raunaq
CAPS 20mg 10 32.00
METALOC

BDH
CAPS 20mg 10 33.21
CAPS 10mg 10 20.13
NILSEC

Max
CAPS 20mg 10 31.70
OCID

Cadila Healthcare
CAPS 10mg 10 20.50
CAPS 20mg 10 38.40
OLIT

Cadila Pharma
CAPS 20mg 10 36.00
OMECID

Saga Labs
CAPS 20mg 10 32.00
CAPS 20mg 10 0.00
OMEGORD

Medispan
CAPS 20mg 10 34.00
OMEPRAL

FDC
CAPS 10mg 10 21.00
CAPS 20mg 10 35.00
OMEPARAZ

Alkem
CAPS 10mg 10 22.00
CAPS 20mg 10 36.25
OMEPREN

Blue Cross
CAPS 10mg 10 20.00
CAPS 20mg 10 36.25
OMEZ

DR. Reddy’s
CAPS 10mg 10 23.67
CAPS 20mg 10 39.87
OMEZOL

Alembic
CAPS 20mg 10 38.25
OMICAP

Micro Labs
TAB 10mg 10 36.00
OMIND

Indoco
CAPS 20mg 10 34.12
OMIZAC

Torrent
CAPS 20mg 10 36.90
OMLINK

Lincoin
CAPS 10mg 10 19.90
CAPS 20mg 10 34.70
ONOCID

Lark
CAPS 20mg 10 362.00
OPAZ

Aglowmed
CAPS 20mg 10 26.90
PROMISEC

Aristo
CAPS 20mg 10 27.39
PROTOCID

Tide
CAPS 20mg 10 45.00
PROTOLOC

USV
CAPS 20mg 10 39.00
CAPS 40mg 10 73.00
PROZOL

CFL
CAPS 20mg 10 36.00
RESEC

Merind
CAPS 20mg 10 39.50
ULZOL

Dabur
CAPS 20mg 10 38.00
WINCID

Wings
CAPS 20mg 10 38.00
ZOLCER-10

Aurobindo
CAPS 10mg 14 28.70
ZOLCER-20

Aurobindo
CAPS 20mg 14 39.20
ZOLCER-40

Aurobindo
CAPS 40mg 10 42.00
ZOPEP

Pharmacia & Upjohn
CAPS 20mg 10 29.10
ZOSEC

Emcure
CAPS 10mg 10 20.00
CAPS 20mg 10 39.00



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Drug Information
 

     

Pharmacokinetics

It is a proton pump inhibitor.It is rapidly absorbed.It supresses the gastric acid secretion by inhibition of Hydrogen Potassium ATPase and thus blocks the final step in gastric acid secretion. It causes almost 100% inhibition of gastric acid secretion in the stomach. It has a plasma 1/2 life of 30-90 min, and duration of action is 24 hours. It is 98 % bound to plasma proteins. It is metabolised in liver and excreted mainly in the urine.

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Indication & Dosage

Oral
DUODENAL ULCER:
20mg/day 4-8 weeks
GASTRIC ULCER: 20mg/day 8 weeks.
REFLUX OESOPHAGITIS: 20mg/day 4-8 days. Omeprazole should preferably be taken in the morning before food.
ZOLLINGER-ELLISON SYNDROME: Start at 60mg once daily. Usual range 20-120mg/day(above 80mg in 2 div doses).

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Action

Suppresses gastric acid secretion by specific inhibition of the enzyme h+k+ ATPase present on the secretory surface of the gastric parietal cell. This blocks the final and common step in gastric acid secretion. Both basal and stinulated acid secretions are inhibited irrespectiveof the stimulus. Peptic activity is reduced. It suppresses Helicobacter Pylore.

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Interaction

It prolongs the elimination of diazepam, warfarin, phenytoin and aminophylline.

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Adverse Effect & Precautions

Nausea, constipation, diarrhoea, skin rash, headache.

Precautions must be taken when taking the drug during pregnancy,cirrhosis, malignancy and prolonged use.
Pregnancy: Safety not established.
Breast Feeding: Contraindicated.
Man: May be used.

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ACICHEK

Boehringer Mannheim

CAPS

20mg

10

29.75

BIOCID

Biochem

CAPS

20mg

10

37.73

CAPS

10mg

10

20.12

BIOZOLE

Sara Biotech

CAP

20mg

10

36.50

COSZOL

CFL

CAPS

20mg

10

20.00

COSZOL 10

CFL

CAP

10mg

10

20.00

COZEP

SPPL

CAPS

10mg

10

20.05

CAPS

20mg

10

37.27

LOKIT

Kramer

CAPS

20mg

10

34.80

CAPS

10mg

6×10

99.60

LOMAC

Cipla

CAPS

10mg

10

20.50

CAPS

20mg

10

38.00

LORESS

Biological E

CAPS

10mg

10

19.58

CAPS

20mg

10

38.00

LOSEC

Emcure

CAPS

10mg

10

20.00

CAPS

20mg

10

39.00

MENZOL-20

Menarini Raunaq

CAPS

20mg

10

32.00

METALOC

BDH

CAPS

20mg

10

33.21

CAPS

10mg

10

20.13

NILSEC

Max

CAPS

20mg

10

31.70

OCID

Cadila Healthcare

CAPS

10mg

10

20.50

CAPS

20mg

10

38.40

OLIT

Cadila Pharma

CAPS

20mg

10

36.00

OMECID

Saga Labs

CAPS

20mg

10

32.00

CAPS

20mg

10

0.00

OMEGORD

Medispan

CAPS

20mg

10

34.00

OMEPRAL

FDC

CAPS

10mg

10

21.00

CAPS

20mg

10

35.00

OMEPARAZ

Alkem

CAPS

10mg

10

22.00

CAPS

20mg

10

36.25

OMEPREN

Blue Cross

CAPS

10mg

10

20.00

CAPS

20mg

10

36.25

OMEZ

DR. Reddy’s

CAPS

10mg

10

23.67

CAPS

20mg

10

39.87

OMEZOL

Alembic

CAPS

20mg

10

38.25

OMICAP

Micro Labs

TAB

10mg

10

36.00

OMIND

Indoco

CAPS

20mg

10

34.12

OMIZAC

Torrent

CAPS

20mg

10

36.90

OMLINK

Lincoin

CAPS

10mg

10

19.90

CAPS

20mg

10

34.70

ONOCID

Lark

CAPS

20mg

10

362.00

OPAZ

Aglowmed

CAPS

20mg

10

26.90

PROMISEC

Aristo

CAPS

20mg

10

27.39

PROTOCID

Tide

CAPS

20mg

10

45.00

PROTOLOC

USV

CAPS

20mg

10

39.00

CAPS

40mg

10

73.00

PROZOL

CFL

CAPS

20mg

10

36.00

RESEC

Merind

CAPS

20mg

10

39.50

ULZOL

Dabur

CAPS

20mg

10

38.00

WINCID

Wings

CAPS

20mg

10

38.00

ZOLCER-10

Aurobindo

CAPS

10mg

14

28.70

ZOLCER-20

Aurobindo

CAPS

20mg

14

39.20

ZOLCER-40

Aurobindo

CAPS

40mg

10

42.00

ZOPEP

Pharmacia & Upjohn

CAPS

20mg

10

29.10

ZOSEC

Emcure

CAPS

10mg

10

20.00

CAPS

20mg

10

39.00

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By |2022-07-20T16:42:54+00:00July 20, 2022|Uncategorized|Comments Off on Omeprazol

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