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Drug Information
Pharmacokinetics
| Indication
& Dosage | Action
| Interacations Adverse
Effects & Precautions |
Brands available in Market
It is a proton pump inhibitor.It is rapidly absorbed.It supresses the gastric acid secretion by inhibition of Hydrogen Potassium ATPase and thus blocks the final step in gastric acid secretion. It causes almost 100% inhibition of gastric acid secretion in the stomach. It has a plasma 1/2 life of 30-90 min, and duration of action is 24 hours. It is 98 % bound to plasma proteins. It is metabolised in liver and excreted mainly in the urine.
Oral
DUODENAL ULCER: 20mg/day 4-8 weeks
GASTRIC ULCER: 20mg/day 8 weeks.
REFLUX OESOPHAGITIS: 20mg/day 4-8 days. Omeprazole should preferably be
taken in the morning before food.
ZOLLINGER-ELLISON SYNDROME: Start at 60mg once daily. Usual range
20-120mg/day(above 80mg in 2 div doses).
Suppresses gastric acid secretion by specific inhibition of the enzyme h+k+ ATPase present on the secretory surface of the gastric parietal cell. This blocks the final and common step in gastric acid secretion. Both basal and stinulated acid secretions are inhibited irrespectiveof the stimulus. Peptic activity is reduced. It suppresses Helicobacter Pylore.
Adverse Effect &
Precautions
Nausea, constipation, diarrhoea,
skin rash, headache.
Precautions must be taken when taking the drug during
pregnancy,cirrhosis, malignancy and prolonged use.
Pregnancy: Safety not established.
Breast Feeding: Contraindicated.
Man: May be used.